Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elena Dneprovskaia"'
Autor:
Dellamary Luis A, Glenn Noronha, John A. Doukas, Lisa Eide, Karin Stebbins, Lisette M. Acevedo, Wolfgang Wrasidlo, David A. Cheresh, Elena Dneprovskaia, Richard Soll, Adrienne Racanelli-Layton, Michael D. Martin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:758-765
Phosphatidylinositol 3-kinases (PI3Ks) are key elements in the signaling cascades that lie downstream of many cellular receptors. In particular, PI3K delta and gamma isoforms contribute to inflammatory cell recruitment and subsequent activation. For
Autor:
Chi Ching Mak, Xianchang Gong, Elena Dneprovskaia, Andrew McPherson, Ved P. Pathak, J. Hood, Binqi Zeng, Boris Klebansky, Richard M. Fine, W. Liao, Wolfgang Wrasidlo, Glenn Noronha, Joel Renick, Ningning Zhao, Y. Zhou, Kathy Barrett, Colleen Gritzen, Moorthy S. S. Palanki, Xinshan Kang, Ge Li, Ute Splittgerber, Richard M. Soll, Daniel L. Lohse, Jianguo Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5546-5550
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as
Publikováno v:
Tetrahedron. 59:8975-8978
A model system for the synthesis of phloroglucinol containing natural products was synthesized. Key steps include a manganic acetate-mediated cyclization and the facile conversion of an alkene into a β-bromoenone.
Autor:
Elena Dneprovskaia, George A. Kraus
Publikováno v:
Tetrahedron Letters. 41:21-24
The Michael addition reactions of α-acyloxy nitrile anions with Michael acceptors are followed by a shift of the acyl group to the α-carbon of the Michael acceptor. Michael acceptors such as acrylates, acrylonitrile and methyl vinyl ketone can be u
A direct connection of a tricyclic analog of methyllycaconitine with 2-methylsuccinimidobenzoic acid
Autor:
Elena Dneprovskaia, George A. Kraus
Publikováno v:
Tetrahedron Letters. 39:2451-2454
An efficient procedure for attaching the methylsuccinimidobenzoate ester unit to an ABE ring segment of methyllycaconitine is described.
Autor:
Chi Ching Mak, Chun P. Chow, Glenn Noronha, Andrew McPherson, Moorthy S.S. Palanki, Joel Renick, Jianguo Cao, Ved P. Pathak, Binqi Zeng, Richard Soll, Elena Dneprovskaia
Publikováno v:
Expert opinion on drug discovery. 4(1)
Background: The synthesis of novel benzotriazine heterocycles was developed independently around the same time by Bischler, Bamberger and Arndt. Over the years, different groups have reported the synthesis of benzotriazine based compounds. Objective:
Autor:
Glen Noronha, Jianguo Cao, Chun Chow, Elena Dneprovskaia, Linda Hwang, Dan Lohse, Chi Ching Mak, Andrew McPherson, Richard M. Fine, Xinshan Kang, Boris Klebansky, Moorthy S.S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d4f3146de588732bf746c8ec5d69ab
https://doi.org/10.2174/978160805201110703010121
https://doi.org/10.2174/978160805201110703010121
Autor:
George A. Kraus, Elena Dneprovskaia
Publikováno v:
ChemInform. 31
The Michael addition reactions of α-acyloxy nitrile anions with Michael acceptors are followed by a shift of the acyl group to the α-carbon of the Michael acceptor. Michael acceptors such as acrylates, acrylonitrile and methyl vinyl ketone can be u
Autor:
Richard L. Klemke, Konstantin Stoletov, Michael Bouvet, Robert M. Hoffman, Igor F. Tsigelny, Elena Dneprovskaia, Peter K. Vogt, Lee J. Arnold, Breda M. Walsh, Adrian Saldanha, Bharat Majeti, David A. Cheresh, Wolfgang Wrasidlo, David J. Shields, Joshua I. Greenberg, Michele McElroy, Sudarshan Anand, Jeff Lindquist, Lisette M. Acevedo, Eric A. Murphy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(9)
Kinases are known to regulate fundamental processes in cancer including tumor proliferation, metastasis, neovascularization, and chemoresistance. Accordingly, kinase inhibitors have been a major focus of drug development, and several kinase inhibitor