Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elena Diez-Cecilia"'
Autor:
Felix S. Meier‐Stephenson, Vanessa C. Meier‐Stephenson, Michael D. Carter, Autumn R. Meek, Yanfei Wang, Luzhe Pan, Qiangwei Chen, Sheila Jacobo, Fan Wu, Erhu Lu, Gordon A. Simms, Laural Fisher, Alaina J. McGrath, Virgil Fermo, Christopher J. Barden, Harman D.S. Clair, Todd N. Galloway, Arun Yadav, Valérie Campágna‐Slater, Mark Hadden, Mark Reed, Marcia Taylor, Brendan Kelly, Elena Diez‐Cecilia, Igri Kolaj, Clarissa Santos, Imindu Liyanage, Braden Sweeting, Paul Stafford, Robert Boudreau, G. Andrew Reid, Ryan S. Noyce, Leanne Stevens, Agnieszka Staniszewski, Hong Zhang, Mamidanna R. V. S. Murty, Pascale Lemaire, Solenne Chardonnet, Christopher D. Richardson, Valérie Gabelica, Edwin DePauw, Richard Brown, Sultan Darvesh, Ottavio Arancio, Donald F. Weaver
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Alzheimer's disease (AD) is characterized by neurotoxic immuno‐inflammation concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and tau, culminating in concurrent, interdependent immunopathic and proteopathic path
Externí odkaz:
https://doaj.org/article/1e2d8b504a1f482e94ad2f6036b37c9c
Autor:
Arash Keshavarzi Arshadi, Julia Webb, Milad Salem, Emmanuel Cruz, Stacie Calad-Thomson, Niloofar Ghadirian, Jennifer Collins, Elena Diez-Cecilia, Brendan Kelly, Hani Goodarzi, Jiann Shiun Yuan
Publikováno v:
Frontiers in Artificial Intelligence, Vol 3 (2020)
SARS-COV-2 has roused the scientific community with a call to action to combat the growing pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved vaccines available for deployment as a frontline defense. Underst
Externí odkaz:
https://doaj.org/article/dc313295629747798bfad07f2859c280
Autor:
Emre Fertan, Kurt R.J. Stover, Michael G. Brant, Paul M. Stafford, Brendan Kelly, Elena Diez-Cecilia, Aimée A. Wong, Donald F. Weaver, Richard E. Brown
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide, producing a number of intermediary metabolites, including 3-hydroxy kynurenine and quinolinic acid, which are involved in the neurodegenerative mechanisms that unde
Externí odkaz:
https://doaj.org/article/7faa4929d5744b3fbb5ecaceba520d76
Autor:
Brendan J. Kelly, Elena Diez-Cecilia, Luzhe Pan, Braden Sweeting, Laura Villar, Alexander Kreft, Mayuri Gupta, Shea L. Johnson, Donald F. Weaver
Publikováno v:
Canadian Journal of Chemistry. 100:660-675
The design of potent indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitors targeting immunopathic neuroinflammation has emerged as an area of interest for the treatment of Alzheimer's disease (AD); additionally, recent findings on the clinical benef
Publikováno v:
Journal of Medicinal Chemistry. 61:3209-3217
Urea transporter A (UT-A) isoforms encoded by the Slc14a2 gene are expressed in kidney tubule epithelial cells, where they facilitate urinary concentration. UT-A1 inhibition is predicted to produce a unique salt-sparing diuretic action in edema and h
Autor:
Elena Diez-Cecilia, Luis J. V. Galietta, Sujin Lee, Puay-Wah Phuan, Onur Cil, Sarah E Levy, Marc O. Anderson, Loretta Ferrera, Amanda L. Reggi, Alannah C Moises, Alan S. Verkman, Eric C. Truong
Publikováno v:
Journal of Medicinal Chemistry. 60:4626-4635
Transmembrane protein 16A (TMEM16A), also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian cells, including epithelia, vascular smooth muscle tissue, electrically excitable cells, and some tumors. TMEM16A
Autor:
Elena Diez-Cecilia, Emre Fertan, Aimee A. Wong, Richard E. Brown, Kurt R. Stover, Paul M. Stafford, Brendan Kelly, Donald F. Weaver, Michael G. Brant
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Vol 10 (2019)
The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide, producing a number of intermediary metabolites, including 3-hydroxy kynurenine and quinolinic acid, which are involved in the neurodegenerative mechanisms that unde
Autor:
Yanfei Wang, Donald F. Weaver, Christopher B. Lavery, Mark A. Reed, Elena Diez-Cecilia, Mark A. MacLean, Mark Stradiotto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:100-104
N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydra
Autor:
Elena Diez-Cecilia, Anshul Bansal, Ritu Mahajan, Amanjot Kaur, Jitender Sharma, Isabel Rozas, Ranjana Aggarwal
Publikováno v:
Medicinal Chemistry Research. 23:1454-1464
A solvent-free quick synthesis of 1-(4′,6′-dimethylpyrimidin-2′-yl)-5-amino-4H-3-arylpyrazoles (3) was accomplished by grinding 2-hydrazino-4,6-dimethylpyrimidine (1) and β-ketonitriles (2) in the presence of p-Toluenesulfonic acid as a cataly
Autor:
Donald F. Weaver, Christopher B. Lavery, Yanfei Wang, Mark Stradiotto, Mark A. MacLean, Mark A. Reed, Elena Diez-Cecilia
Publikováno v:
ChemInform. 47
N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydra