Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Elena Di Daniel"'
Autor:
Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward Jenkins, Frederik H. Lassen, Sam J. Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou, Fangyuan Cao, Xiaonan Zheng, Ricardo A. Fernandes, Tao Dong, Edward W. Tate, Elena Di Daniel, Benedikt M. Kessler
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114152- (2024)
Summary: Activation of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome complex is an essential innate immune signaling mechanism. To reveal how human NLRP3 inflammasome assembly and activation are controlled, in particular b
Externí odkaz:
https://doaj.org/article/a5167cfa972c4f8d8edd1f27601d7520
Autor:
Juliane Obst, Hazel L. Hall-Roberts, Thomas B. Smith, Mira Kreuzer, Lorenza Magno, Elena Di Daniel, John B. Davis, Emma Mead
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Human genetic studies have linked rare coding variants in microglial genes, such as TREM2, and more recently PLCG2 to Alzheimer’s disease (AD) pathology. The P522R variant in PLCG2 has been shown to confer protection for AD and to result i
Externí odkaz:
https://doaj.org/article/1c7337e110a44e7892c77769f789ed8a
Autor:
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 for
Externí odkaz:
https://doaj.org/article/1fa617be6c444588bad302d2d3607a84
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put int
Externí odkaz:
https://doaj.org/article/2e71fa84571f402fb0574b920e429024
Autor:
Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B. Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S. James, Emma Mead, John B. Davis, Sally A. Cowley
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-27 (2020)
Abstract Background TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. I
Externí odkaz:
https://doaj.org/article/7003790f6cc94c199bdb2b9d9a1caf4d
Autor:
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/87b5d1c433174420bb315595d76f8e3d
Autor:
Elena Di Daniel, Emma Mead, Juliane Obst, Thomas B. Smith, Hazel Hall-Roberts, John B. Davis, Mira Kreuzer, Lorenza Magno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Human genetic studies have linked rare coding variants in microglial genes, such as TREM2, and more recently PLCG2 to Alzheimer’s disease (AD) pathology. The P522R variant in PLCG2 has been shown to confer protection for AD and to result in a subtl
Autor:
Thomas B. Smith, Jimena Monzón-Sandoval, Juliane Obst, Emma Mead, William James, John B. Davis, Hazel Hall-Roberts, Caleb Webber, Sally A. Cowley, Elena Di Daniel, Devika Agarwal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-27 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. In AD mous
Autor:
David Brough, Kanisa Arunasalam, Elena Di Daniel, Sohaib Nizami, Tryfon Zarganes-Tzitzikas, James Cook, Catherine B. Lawrence, John B. Davis, Jack Peter Green
Publikováno v:
Immunology
Nizami, S, Arunasalam, K, Green, J, Cook, J, Lawrence, C B, Zarganes-Tzitzikas, T, Davis, J B, Daniel, E D & Brough, D 2020, ' Inhibition of the NLRP3 inflammasome by HSP90 inhibitors ', Immunology . https://doi.org/10.1111/imm.13267
Nizami, S, Arunasalam, K, Green, J, Cook, J, Lawrence, C B, Zarganes-Tzitzikas, T, Davis, J B, Daniel, E D & Brough, D 2020, ' Inhibition of the NLRP3 inflammasome by HSP90 inhibitors ', Immunology . https://doi.org/10.1111/imm.13267
Summary Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro‐inflammatory cytok
Autor:
Paul Brennan, David Brough, Kanisa Arunasalam, Val Millar, John B. Davis, Tryfon Zarganes-Tzitzikas, Elena Di Daniel, Sohaib Nizami, Daniel Ebner, Gary Tresadern
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.