Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Elena Cubedo"'
Autor:
Jianshi Yu, Jace W. Jones, Lutecia Pereira, Maureen A. Kane, Melissa Fishel, Arthur Zelent, Elena Cubedo, Boris A. Leibovitch, Keely Pierzchalski, Eduardo F. Farias, Almudena Bosch, Samuel Waxman, Nidhi Bansal
Publikováno v:
Oncotarget
// Nidhi Bansal 1 , Almudena Bosch 1, * , Boris Leibovitch 1, * , Lutecia Pereira 2 , Elena Cubedo 2 , Jianshi Yu 3 , Keely Pierzchalski 3 , Jace W. Jones 3 , Melissa Fishel 1 , Maureen Kane 3 , Arthur Zelent 2 , Samuel Waxman 1 , Eduardo Farias 1 1
Publikováno v:
Cancer Research. 77:1906-1906
Breast cancer is the leading cause of death in women, primarily due to metastatic disease rather than the primary tumor. Median survival with metastatic breast cancer is 3 years, with no statistically significant change in survival in over 20 years.
Autor:
Shruti Bhatt, Xiaoyu Jiang, Aharon G. Freud, Shuchun Zhao, Jose A. Martinez-Climent, Andrew J. Gentles, Chuanxin Huang, Izidore S. Lossos, Xiaoqing Lu, Isidro Sánchez-García, Elena Cubedo, Isabel Romero-Camarero, Yasodha Natkunam, Carlos E. Bacchi, Ari Melnick
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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LMO2 regulates gene expression by facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the germinal center (GC) and is expressed in GC-derived non-Hodgkin lymphomas. LMO2 is one of the mos
Autor:
Izidore S. Lossos, Liat Nadav Dagan, Klaus Rajewsky, Shruti Bhatt, Xiaoyu Jiang, Elena Cubedo
Publikováno v:
Blood. 119:513-520
HGAL, a prognostic biomarker in patients with diffuse large B-cell lymphoma and classic Hodgkin lymphoma, inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade and interacting with actin and myosin proteins. Although
Publikováno v:
FEBS Journal. 278:3065-3075
Human germinal center-associated lymphoma (HGAL) and LIM domain only-2 (LMO2) are proteins highly expressed in germinal center (GC) B lymphocytes. HGAL and LMO2 are also expressed in GC-derived lymphomas and distinguish biologically distinct subgroup
Autor:
Maria Victoria Dominguez, María Font, Carmen Sanmartín, Lucia Cordeu, Juan Antonio Palop, Elena Cubedo, Jesús García-Foncillas
Publikováno v:
Archiv der Pharmazie. 341:28-41
In the search for new derivatives with anticancer activity that are able to induce a selective pro-apoptotic mechanism in cancer cells, we have designed, synthesized, and evaluated a series of new 2-(alkylsulfanyl)-N-alkylpyrido[2,3-d]pyrimidine-4-am
Autor:
Izidore S. Lossos, Jun Chen, Raquel Malumbres, David M. Helfman, Xiaoqing Lu, Elena Cubedo Gil
Publikováno v:
Blood. 110:4268-4277
HGAL is a newly identified germinal center (GC)–specific gene whose expression by the tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas. The function of HGAL is unknown. Previous
Autor:
Xabi Sáenz, Amaia Rebollo, María Font, Beatriz Mendivil, Mikel Echeverría, Lucia Cordeu, Elena Cubedo, Ma Victoria Domínguez, Juan Antonio Palop, Jesús García-Foncillas, Hector Chozas, Carmen Sanmartín, Eva Bandrés
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1659-1669
In order to obtain less toxic antitumoral compounds we have looked for novel compounds with anticancer activity based on proapoptotic mechanisms. The compounds studied in this work are derivatives of bicyclic aromatic systems like pyrido[2,3-d]pyrimi
Autor:
Carmen Sanmartín, Jesús García-Foncillas, Elena Ardaiz, J. A. Palop, Lucia Cordeu, Elena Cubedo, María Font
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1942-1948
In an attempt to discover the essential features that would allow us to explain the differences in cytotoxic activity shown by a series of symmetrical diaryl derivatives with nitrogenated functions, we have studied by molecular modelling techniques t
Autor:
Iranzu González, Elena Cubedo, Raquel Malumbres, Eva Bandrés, Alvaro Escalada, Jesús García-Foncillas, Ruth Zarate, Beatriz Honorato, Enrique de Alava
Publikováno v:
Journal of Pediatric Hematology/Oncology. 27:537-542
The t(11;22)(q24;q12) translocation is present in up to 95% of Ewing tumor patients and results in the formation of an EWS-FLI-1 fusion gene that encodes a chimeric transcription factor. Many alternative forms of EWS-FLI-1 exist because of variations