Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elena Crawford"'
Autor:
Giordano de Guglielmo, Marsida Kallupi, Matthew B. Pomrenze, Elena Crawford, Sierra Simpson, Paul Schweitzer, George F. Koob, Robert O. Messing, Olivier George
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Withdrawal from alcohol activates neurons in the central amygdala (CeA) and increases craving for alcohol. The authors show that these neurons predominantly express CRF and project to the BNST. Inactivation of this pathway reduces the dependence-rela
Externí odkaz:
https://doaj.org/article/8db57a0776314be7af8485f7e6d97794
Autor:
Emmanuel Breysse, Carrie L. Wade, Marsida Kallupi, Paul Schweitzer, Olivier George, Daniel O Hernandez, George F. Koob, Elena Crawford, Giordano de Guglielmo, Christelle Baunez
Publikováno v:
Neuropsychopharmacology. 42:1850-1859
Opioid addiction, including addiction to heroin, has markedly increased in the past decade. The cost and pervasiveness of heroin addiction, including resistance to recovery from addiction, provide a compelling basis for developing novel therapeutic s
Autor:
Paul Schweitzer, Giordano de Guglielmo, George F. Koob, Robert O. Messing, Sierra Simpson, Matthew B. Pomrenze, Marsida Kallupi, Elena Crawford, Olivier George
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ens
Autor:
Olivier George, Giordano de Guglielmo, Leandro F. Vendruscolo, Elena Crawford, Molly Brennan, Maury Cole, Bruce T. Hope, George F. Koob, Sarah Kim
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 36, iss 36
Abstinence from alcohol is associated with the recruitment of neurons in the central nucleus of the amygdala (CeA) in nondependent rats that binge drink alcohol and in alcohol-dependent rats. However, whether the recruitment of this neuronal ensemble
Autor:
Lindsay N. Cates, Marisa Roberto, Tali Nadav, Hang Yin, K. Cheng, Sarah E. Montgomery, Elena Crawford, Amanda J. Roberts, A. M. Delucchi, Michal Bajo
Publikováno v:
Alcohol and Alcoholism. 51:541-548
Aims Several lines of evidence support a critical role of TLR4 in the neuroimmune responses associated with alcohol disorders and propose inhibitors of TLR4 signaling as potential treatments for alcoholism. In this work, we investigated the effect of
Autor:
Pascale Koebel, Hector Vargas-Perez, Ami Cohen, Pietro Paolo Sanna, Joel E. Schlosburg, Michal Chwalek, Brigitte L. Kieffer, Derek van der Kooy, Elena Crawford, John Freiling, Geith Maal-Bared, Laura A. Tan, Paul E. Sawchenko, Taryn E. Grieder, Laura Clarke, Melissa A. Herman, Candice Contet, Andrew R. Tapper, Marisa Roberto, Olivier George, George F. Koob, Vez Repunte-Canonigo
Publikováno v:
Nature neuroscience
Nature neuroscience, vol 17, iss 12
Nature neuroscience, vol 17, iss 12
SUMMARY Dopaminergic neurons in the ventral tegmental area (VTA) are well known for their role in mediating the positive reinforcing effects of drugs of abuse. Here, we identify in rodents and humans a population of VTA dopamine neurons co-expressing
Autor:
Leandro F. Vendruscolo, Joel E. Schlosburg, Timothy W. Whitfield, Olivier George, George F. Koob, Paula E. Park, Elena Crawford
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 33, iss 49
The abuse of opioid drugs, both illicit and prescription, is a persistent problem in the United States, accounting for >1.2 million users who require treatment each year. Current treatments rely on suppressing immediate withdrawal symptoms and replac
Autor:
Camryn D. Allen, Elena Crawford, Olivier George, Edward Grigoryan, Shayla Vu, Chitra D. Mandyam, John Freiling, George F. Koob, Chelsea Sanders
Publikováno v:
Proceedings of the National Academy of Sciences. 109:18156-18161
Chronic intermittent access to alcohol leads to the escalation of alcohol intake, similar to binge drinking in humans. Converging lines of evidence suggest that impairment of medial prefrontal cortex (mPFC) cognitive function and overactivation of th
Autor:
Oliver Hsu, Natalie M. Zahr, Edith V. Sullivan, Adolf Pfefferbaum, Elena Crawford, Torsten Rohlfing, Dirk Mayer, Shara Vinco
Publikováno v:
Brain Research. 1300:65-78
Neurophysiological, biochemical, and anatomical evidence implicates glutamatergic mechanisms in epileptic seizures. Until recently, however, longitudinal characterization of in vivo glutamate dynamics was not possible. Here, we present data using in
Autor:
Elena Crawford, Youn Kyung Lee, Cindy K. Funk, Heather N. Richardson, Chitra D. Mandyam, Stephanie H. Chan, George F. Koob
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 1, Pp 1-10 (2009)
Experimenter-delivered alcohol decreases adult hippocampal neurogenesis, and hippocampal-dependent learning and memory. The present study used clinically relevant rodent models of nondependent limited access alcohol self-administration and excessive