Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elena Christian"'
Autor:
Pratiksha I. Thakore, Alexandra Schnell, Maryann Zhao, Linglin Huang, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Sai Ma, Venkat Sankar, Samuele Notarbartolo, Jason D. Buenrostro, Federica Sallusto, Nikolaos A. Patsopoulos, Orit Rozenblatt-Rosen, Vijay K. Kuchroo, Aviv Regev
Th17 cells are a heterogenous cell population consisting of non-pathogenic Th17 cells (npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are potent mediators of tissue inflammation. To reveal regulatory mechanisms u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d169e14c7d30197d7fc92e62656609e5
https://doi.org/10.1101/2022.02.26.482041
https://doi.org/10.1101/2022.02.26.482041
Autor:
Kerry A. Pierce, Manoocher Soleimani, David DeTomaso, Lloyd Bod, Julian Avila-Pacheco, Elliot Akama-Garren, Brandon Schellhaass, Nir Yosef, Vasundhara Singh, Pratiksha I. Thakore, Allon Wagner, Sarah Zaghouani, Clary B. Clish, Raymond A. Sobel, James Kaminski, Alexandra Schnell, Erika L. Pearce, Chao Wang, Johannes Fessler, Daniel J. Puleston, Aviv Regev, Vijay K. Kuchroo, Elena Christian, Noga Ron-Harel, Vivian Paraskevi Douglas, Marcia C. Haigis
Publikováno v:
Cell
Cell, vol 184, iss 16
Cell, vol 184, iss 16
Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a516f7d904eb1d13dfbea99d5d9100ca
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
Autor:
Kouichiro Goto, Vijay K. Kuchroo, Manu Rangachari, Hitoshi Okada, Chao Wang, Orit Rosenblatt-Rosen, Elena Christian, Tak W. Mak, Chen Zhu, Karen O. Dixon, Kathleen Newcomer, Aviv Regev, Guangxiang Gu, Meromit Singer, Huiyuan Zhang, Markus A. Schramm, Sheng Xiao, Sarah Zaghouani
Publikováno v:
Science Advances
Tim-3 adaptor protein Bat3 regulates T cell terminal differentiation and exhaustion in an mTORC2-dependent manner.
T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of
T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of
Autor:
Roberto R. Ricardo-Gonzalez, Leif S. Ludwig, Georg Gasteiger, Holly R. Steach, Lina Kroehling, Maria Carolina Amezcua Vesely, Monika S. Kowalczyk, Autumn G. York, Mathias H. Skadow, Richard M. Locksley, Ruaidhri Jackson, Piotr Bielecki, Caroline B. M. Porter, Heather M. McGee, Aviv Regev, Hao Xu, Michal Slyper, Samantha J. Riesenfeld, Danielle Dionne, Will Bailis, Amanda J. Kedaigle, Elena Christian, Abigail Jarret, Richard A. Flavell, Elena Torlai Triglia, Paula Licona-Limón, Liming Tao, Mi Lian, Nicola Gagliani, Christoph Muus, Parastou Yaghoubi, Jan-Christian Hütter
Publikováno v:
Nature, vol 592, iss 7852
Nature
Nature
Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their expression of specific transcription factors and cytokines1. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84e4925bc69bf051396bee0fdabe30e
https://escholarship.org/uc/item/4cc9s2xz
https://escholarship.org/uc/item/4cc9s2xz
Autor:
Danyang He, Heping Xu, Huiyuan Zhang, Ruihan Tang, Yangning Lan, Ruxiao Xing, Shaomin Li, Elena Christian, Yu Hou, Paul Lorello, Barbara Caldarone, Jiarui Ding, Lan Nguyen, Danielle Dionne, Pratiksha Thakore, Alexandra Schnell, Jun R. Huh, Orit Rozenblatt-Rosen, Aviv Regev, Vijay K. Kuchroo
Publikováno v:
Immunity
To accommodate the changing needs of the developing brain, microglia must undergo substantial morphological, phenotypic, and functional reprogramming. Here, we examined whether cellular metabolism regulates microglial function during neurodevelopment
Autor:
Aleah C. Holmes, Kaixi Zhao, Elena Christian, Judith P. Sinn, Kari A. Peter, Sara M. Klee, Cristina Rosa, Brian L. Lehman, Timothy W. McNellis
Publikováno v:
J Bacteriol
The Gram-negative enterobacteriumErwinia amylovoracauses fire blight disease in apple and pear trees. Lipopolysaccharides and the exopolysaccharide amylovoran are essentialE. amylovoravirulence factors. We found that mutations inrfbXdisrupted amylovo
Autor:
Sachet A. Shukla, Wandi Zhang, Annie Apffel, Irwin Jungreis, Susan Klaeger, Aviv Regev, Bo Li, François Aguet, Zhe Ji, Tamara Ouspenskaia, Christina R. Hartigan, Nir Hacohen, Yuen Ting Chow, Catherine J. Wu, Gad Getz, Siranush Sarkizova, Travis Law, Phuong M. Le, Giacomo Oliveira, Steven A. Carr, Manolis Kellis, Derin B. Keskin, Karl R. Clauser, Hasmik Keshishian, Elena Christian, Binyamin A. Knisbacher, Pavan Bachireddy
Tumor epitopes – peptides that are presented on surface-bound MHC I proteins - provide targets for cancer immunotherapy and have been identified extensively in the annotated protein-coding regions of the genome. Motivated by the recent discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6ad79dd0b14c97faf6d14c6d58176
Autor:
Karl R. Clauser, Gad Getz, Wandi Zhang, Elena Christian, Siranush Sarkizova, Susan Klaeger, Bo Li, Yuen Ting Chow, Annie Apffel, Sune Justesen, Binyamin A. Knisbacher, François Aguet, Pavan Bachireddy, Catherine J. Wu, Aviv Regev, Christina R. Hartigan, Nir Hacohen, Sarah Chen, Irwin Jungreis, Zhe Ji, Hasmik Keshishian, Sachet A. Shukla, Phuong M. Le, Steven A. Carr, Tamara Ouspenskaia, Giacomo Oliveira, Travis Law, Manolis Kellis, Derin B. Keskin
Publikováno v:
Nature biotechnology. 40(2)
Tumor-associated epitopes presented on MHC-I that can activate the immune system against cancer cells are typically identified from annotated protein-coding regions of the genome, but whether peptides originating from novel or unannotated open readin
Autor:
Giulia Escobar, Nandini Acharya, Meromit Singer, Huiyuan Zhang, Marcus Bosenberg, Vijay K. Kuchroo, Karen O. Dixon, Davide Mangani, Aviv Regev, Geoffrey Fell, Elena Christian, Junrong Xia, Donna Neuberg, Orit Rozenblatt-Rosen, Michelle Ferreira, Asaf Madi, Shai Dulberg, Katherine Tooley, Max Klapholz, Ana C. Anderson
Publikováno v:
PMC
Summary Identifying signals in the tumor microenvironment (TME) that shape CD8+ T cell phenotype can inform novel therapeutic approaches for cancer. Here, we identified a gradient of increasing glucocorticoid receptor (GR) expression and signaling fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f52a69ee51295058c26393d17ad06
https://hdl.handle.net/1721.1/133832
https://hdl.handle.net/1721.1/133832
Autor:
Max Klapholz, Karen O. Dixon, Vijay K. Kuchroo, Ana C. Anderson, Elena Christian, Davide Mangani, Geoffrey Fell, Donna Neuberg, Junrong Xia, Katherine Tooley, Aviv Regev, Nandini Acharya, Orit Rozenblatt-Rosen, Asaf Madi, Meromit Singer, Huiyuan Zhang
Identifying signals in the tumor microenvironment (TME) that promote CD8+ T cell dysfunction can inform improved therapeutic approaches for cancer. Here, we identify that Nr3c1, the gene encoding the glucocorticoid receptor (GR), is highly expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5904fdc6c64f16b6af6c1bbbe8a13ba