Výsledky vyhledávání - "Elena Chklovskaia"

Reconstitution of dendritic and natural killer–cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand

Autor: Alois Gratwohl, Elena Chklovskaia, Aleksandra Wodnar-Filipowicz, Catherine Nissen, Mario Bargetzi, Pegah Nowbakht

Publikováno v: Blood. 103:3860-3868

Recovery of dendritic cells (DCs) and natural killer (NK) cells after allogeneic stem cell transplantation (SCT) is important for allograft responses and antitumor immunity and thus for treatment outcome. Regulation of this regenerative process is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fe58a8d800f50a714fa7ba3a78c413
https://doi.org/10.1182/blood-2003-04-1200

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FLT3 ligand gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens

Autor: Michael Heberer, Markus Trutmann, Giulio C. Spagnoli, Elena Chklovskaia, Judith Kloth, Thomas Kocher, Eugenia Remmel, Paul Zajac, Christoph Noppen, Luigi Terracciano

Publikováno v: International Journal of Cancer. 86:238-243

Granulocyte-macrophage colony stimulating factor (GM-CSF) gene expression and protein production were investigated in colorectal cancer cell lines and surgical specimens. In 6 of 6 established tumor lines, expression of the GM-CSF gene was observed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757b2729b8fc7d38e1eb77faf024596f
https://doi.org/10.1002/(sici)1097-0215(20000415)86:2<238::aid-ijc13>3.0.co

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Chronic overexpression of membrane-bound flt3 ligand by T lymphocytes in severe aplastic anaemia

Autor: Otmar Pfister, Christoph Rahner, Catherine Nissen, Nina Hurwitz, S. D. Lyman, Wendy Jansen, Elena Chklovskaia, Kinga Mészáros, Aleksandra Wodnar-Filipowicz, Natalia Bogatcheva

Publikováno v: British Journal of Haematology. 109:211-220

Aplastic anaemia (AA) is an immune-mediated bone marrow failure associated with high serum levels of flt3 ligand (FL). We examined expression of the membrane-bound isoform of FL in peripheral blood and bone marrow cells from AA patients at diagnosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2100b93fb8e59fef9185204cad9320f
https://doi.org/10.1046/j.1365-2141.2000.02008.x

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Mechanism of flt3 Ligand Expression in Bone Marrow Failure: Translocation From Intracellular Stores to the Surface of T Lymphocytes After Chemotherapy-Induced Suppression of Hematopoiesis

Autor: Stewart D. Lyman, Wendy Jansen, Nissen C, Aleksandra Wodnar-Filipowicz, Lukas Landmann, Elena Chklovskaia, Christoph Rahner

Publikováno v: Blood. 93:2595-2604

The flt3 ligand (FL) is a growth factor for primitive hematopoietic cells. Serum levels of FL are inversely related to the number and proliferative capacity of early hematopoietic progenitors. We sought to elucidate the molecular mechanism underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9844b82f06572b3771fc754c9a240d9a
https://doi.org/10.1182/blood.v93.8.2595

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High Incidence of Transiently Appearing Complement-Sensitive Bone Marrow Precursor Cells in Patients with Severe Aplastic Anemia - A Possible Role of High Endogenous IL-2 in Their Suppression

Autor: Bruno Speck, Salima Sadallah, Aleksandra Wodnar-Filipowicz, Alois Gratwohl, Nissen C, André Tichelli, Wendy Jansen, Y. Moser, Christoph Warthmann, Elena Chklovskaia, Verena dalle Carbonare, Silvia Sendelov

Publikováno v: Acta Haematologica. 101:165-172

In a prospective long-term study on the incidence of paroxysmal nocturnal hemoglobinuria (PNH), 115 consecutive patients with severe aplastic anemia (SAA), 97 treated with antilymphocyte globulin (ALG) and 18 with bone marrow transplantation (BMT), w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d5e9cee1866cfc078233cf0361a16b
https://doi.org/10.1159/000040948

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Condensation of the plasma membrane at the site of T lymphocyte activation

Autor: Barbara Fazekas de St Groth, Thomas Harder, Elena Chklovskaia, Katharina Gaus, Wendy Jessup

Publikováno v: The Journal of Cell Biology

After activation, T lymphocytes restructure their cell surface to form membrane domains at T cell receptor (TCR)–signaling foci and immunological synapses (ISs). To address whether these rearrangements involve alteration in the structure of the pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd6068d7350555485fdeeb0b9934e3d
http://ora.ox.ac.uk/objects/uuid:f2311910-d295-4c09-af98-9c5d6e35586e

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Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A

Autor: Lukas Landmann, Christoph Rahner, Otmar Pfister, Catherine Nissen, Aleksandra Wodnar-Filipowicz, Elena Chklovskaia

Publikováno v: Macquarie University

The flt3 ligand (FL) is a growth and differentiation factor for primitive hematopoietic precursors, dendritic cells, and natural killer cells. Human T lymphocytes express FL constitutively, but the cytokine is retained intracellularly within the Golg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f416e309fd6e979b6ad8e1b59f184d48
https://pubmed.ncbi.nlm.nih.gov/11159533

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Umbilical cord blood from preterm human fetuses is rich in committed and primitive hematopoietic progenitors with high proliferative and self-renewal capacity

Autor: Catherine Nissen, Wolfgang Holzgreve, André Tichelli, Aleksandra Wodnar-Filipowicz, Wendy Jansen, Annette Wyrsch, Verena Dalle Carbonare, Elena Chklovskaia, Daniel Surbek

Publikováno v: Experimental hematology. 27(8)

Human umbilical cord blood (CB) has been recognized as a source of hematopoietic stem cells for transplantation. While hematopoietic properties of neonatal CB from full-term pregnancies have been well characterized, little is known about CB from earl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de67be60098e16883f46d13318f60d83
https://pubmed.ncbi.nlm.nih.gov/10428511

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