Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Elena Chiroli"'
Autor:
Mattia Pavani, Elena Chiroli, Camilla Cancrini, Fridolin Gross, Paolo Bonaiuti, Stefano Villa, Fabio Giavazzi, Vittoria Matafora, Angela Bachi, Luca L. Fava, Tiziana Lischetti, Andrea Ciliberto
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112215- (2023)
Summary: Drugs targeting microtubules rely on the mitotic checkpoint to arrest cell proliferation. The prolonged mitotic arrest induced by such drugs is followed by a G1 arrest. Here, we follow for several weeks the fate of G1-arrested human cells af
Externí odkaz:
https://doaj.org/article/63be34cdd8944fb8a7ad24b0ae51f05d
Autor:
Ivana Primorac, John R Weir, Elena Chiroli, Fridolin Gross, Ingrid Hoffmann, Suzan van Gerwen, Andrea Ciliberto, Andrea Musacchio
Publikováno v:
eLife, Vol 2 (2013)
Regulation of macromolecular interactions by phosphorylation is crucial in signaling networks. In the spindle assembly checkpoint (SAC), which enables errorless chromosome segregation, phosphorylation promotes recruitment of SAC proteins to tensionle
Externí odkaz:
https://doaj.org/article/66a6b5113ddb4ac7aceb2f6192a11fb9
Autor:
Fridolin Gross, Marco Cosentino Lagomarsino, Martin Štefl, Paolo Bonaiuti, Andrea Corno, Michael Knop, Claudio Vernieri, Andrea Ciliberto, Elena Chiroli
Publikováno v:
Current Biology-CB
Current Biology-CB, Elsevier, 2018, 28 (1), pp.28-37.e7. ⟨10.1016/j.cub.2017.11.031⟩
Current Biology-CB, Elsevier, 2018, 28 (1), pp.28-37.e7. ⟨10.1016/j.cub.2017.11.031⟩
International audience; Improperly attached chromosomes activate the mitotic checkpoint that arrests cell division before anaphase. Cells can maintain an arrest for several hours but eventually will resume proliferation, a process we refer to as adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8834d51c70ebdea3d8c2a86b46ce44
https://hal.sorbonne-universite.fr/hal-02129840
https://hal.sorbonne-universite.fr/hal-02129840
Publikováno v:
Cell Cycle. 13:1590-1601
In budding yeast, the septins are assembled into structures that undergo dramatic changes during the cell cycle. The molecular mechanisms that drive these remodelings are not fully uncovered. In this study we describe a characterization of Vhs2, a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a9fe2da640566ac6c3341de2ba420e
https://doi.org/10.4161/cc.28561
https://doi.org/10.4161/cc.28561
Autor:
Stefano Maffini, Elena Chiroli, Andrea Ciliberto, Vittoria Matafora, Angela Bachi, Fridolin Gross, Claudio Vernieri, Andrea Corno, Marco Cosentino Lagomarsino
Publikováno v:
Life Science Alliance
Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile.
Eukaryotic cells tre
Eukaryotic cells tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde01121068a08f40864bcff8301a481
https://doi.org/10.26508/lsa.201900380
https://doi.org/10.26508/lsa.201900380
Publikováno v:
The Journal of Cell Biology
PP2ACdc55 dephosphorylates APC/CCdc20 to prevent anaphase, an effect that is counteracted by Cdc28/Clbs to allow for spindle checkpoint adaptation.
The spindle checkpoint arrests cells in metaphase until all chromosomes are properly attached to
The spindle checkpoint arrests cells in metaphase until all chromosomes are properly attached to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee97962fc611e75d0381f1e95297b403
https://doi.org/10.1083/jcb.201303033
https://doi.org/10.1083/jcb.201303033
Autor:
Heiko Muller, Luca Mariani, Luigi Nezi, Andrea Musacchio, Simonetta Piatti, Elena Chiroli, Andrea Ciliberto
Publikováno v:
Current Biology. 22:1900-1908
Summary Background The spindle assembly checkpoint (SAC) arrests cells when kinetochores are unattached to spindle microtubules. The signaling pathway is initiated at the kinetochores by one SAC component, Mad2, which catalyzes the initial steps of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ed428226a6ac7173ad396959a7d2ed
https://doi.org/10.1016/j.cub.2012.08.028
https://doi.org/10.1016/j.cub.2012.08.028
Publikováno v:
Molecular Cell. 44(5):710-720
The spindle assembly checkpoint (SAC) restricts mitotic exit to cells that have completed chromosome-microtubule attachment. Cdc20 is a bifunctional protein. In complex with SAC proteins Mad2, BubR1, and Bub3, Cdc20 forms the mitotic checkpoint compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7668142bf6a38f40d1189cb86d037f43
Publikováno v:
Molecular Biology of the Cell. 20:2626-2637
The spindle assembly checkpoint (SAC) is an evolutionarily conserved surveillance mechanism that delays anaphase onset and mitotic exit in response to the lack of kinetochore attachment. The target of the SAC is the E3 ubiquitin ligase anaphase-promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7442abbec8d2e13670e29c44b28455c1
https://doi.org/10.1091/mbc.e08-11-1150
https://doi.org/10.1091/mbc.e08-11-1150
Publikováno v:
The Journal of Cell Biology
Faithful chromosome transmission requires establishment of sister chromatid cohesion during S phase, followed by its removal at anaphase onset. Sister chromatids are tethered together by cohesin, which is displaced from chromosomes through cleavage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0003db2d3607d161cffda12ede8cd7d2
https://doi.org/10.1083/jcb.200609088
https://doi.org/10.1083/jcb.200609088