Rapid Flow Cytometry-Based Test for the Diagnosis of Lipopolysaccharide Responsive Beige-Like Anchor (LRBA) Deficiency

Autor: Laura Gámez-Díaz, Elena C. Sigmund, Veronika Reiser, Werner Vach, Sophie Jung, Bodo Grimbacher

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The diagnosis of lipopolysaccharide-responsive beige-like-anchor-protein (LRBA) deficiency currently relies on gene sequencing approaches that do not support a timely diagnosis and clinical management. We developed a rapid and sensitive test for clin

Externí odkaz: https://doaj.org/article/fed4f662791b45d396b3ee064fe2980d

Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice.

Autor: Elena C Sigmund, Lilian Baur, Philipp Schineis, Jorge Arasa, Victor Collado-Diaz, Martina Vranova, Rolf A K Stahl, Marcus Thelen, Cornelia Halin

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0249068 (2021)

Atypical chemokine receptor ACKR3 (formerly CXCR7) is a scavenging receptor that has recently been implicated in murine lymphatic development. Specifically, ACKR3-deficiency was shown to result in lymphatic hyperplasia and lymphedema, in addition to

Externí odkaz: https://doaj.org/article/00cb1bafafed433f9389a983fb5f9f10

Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics

Autor: Mona C. Friess, Ioannis Kritikos, Philipp Schineis, Jessica Danielly Medina-Sanchez, Anastasia-Olga Gkountidi, Angela Vallone, Elena C. Sigmund, Corina Schwitter, Martina Vranova, Christoph Matti, Jorge Arasa, Cansaran Saygili Demir, Esther Bovay, Steven T. Proulx, Michio Tomura, Antal Rot, Daniel F. Legler, Tatiana V. Petrova, Cornelia Halin

Publikováno v: Cell Reports, 38 (5)
Friess, Mona C; Kritikos, Ioannis; Schineis, Philipp; Medina-Sanchez, Jessica Danielly; Gkountidi, Anastasia-Olga; Vallone, Angela; Sigmund, Elena C; Schwitter, Corina; Vranova, Martina; Matti, Christoph; Arasa, Jorge; Saygili Demir, Cansaran; Bovay, Esther; Proulx, Steven T; Tomura, Michio; Rot, Antal; Legler, Daniel F; Petrova, Tatiana V; Halin, Cornelia (2022). Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell reports, 38(5), p. 110334. Cell Press 10.1016/j.celrep.2022.110334

T cell migration via afferent lymphatics to draining lymph nodes (dLNs) depends on expression of CCR7 in T cells and CCL21 in the lymphatic vasculature. Once T cells have entered lymphatic capillaries, they slowly migrate into contracting collecting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51c1dcb4ca476e8a49312f08b854f8f

Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice

Autor: Rolf A.K. Stahl, Cornelia Halin, Philipp Schineis, Lilian Baur, Elena C. Sigmund, Jorge Arasa, Victor Collado-Diaz, Martina Vranova, Marcus Thelen

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0249068 (2021)
PLoS ONE
PLoS ONE, 16 (4)

Atypical chemokine receptor ACKR3 (formerly CXCR7) is a scavenging receptor that has recently been implicated in murine lymphatic development. Specifically, ACKR3-deficiency was shown to result in lymphatic hyperplasia and lymphedema, in addition to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef5afd7013d20afe26c4e3af5ea5cda
https://doi.org/10.1371/journal.pone.0249068