Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elena C. Leon"'
Autor:
David R. Calabrese, Xiang Chen, Elena C. Leon, Snehal M. Gaikwad, Zaw Phyo, William M. Hewitt, Stephanie Alden, Thomas A. Hilimire, Fahu He, Aleksandra M. Michalowski, John K. Simmons, Lindsey B. Saunders, Shuling Zhang, Daniel Connors, Kylie J. Walters, Beverly A. Mock, John S. Schneekloth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 stru
Externí odkaz:
https://doaj.org/article/d45674f52573447395e321fc6dc2bc80
Autor:
Beverly A. Mock, Kylie J. Walters, John K. Simmons, Shuling Zhang, Snehal M. Gaikwad, John S. Schneekloth, Elena C. Leon, Fahu He, David R. Calabrese, Daniel Connors, William M. Hewitt, Stephanie Alden, Aleksandra M. Michalowski, Thomas A. Hilimire, Zaw Phyo, Lindsey B. Saunders, Xiang Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between dif
Autor:
Timothy Hoey, Frank Jing, Emma Xu, Zoe Duclos, JianMin Lin, Tawny Neal Qureshi, Aliya Zeng, Chetan Srinath, Christopher A. Reid, Emily R. Nettesheim, Huanyu Zhou, Tae Won Chung, Samantha Jones, Laura M Lombardi, William Prince, Jin Yang, Jun Liu, Kathryn N. Ivey, Elena C. Leon, Charles Feathers
Publikováno v:
Circulation Research. 127
Heart failure affects an estimated 38 million people worldwide and is typically caused by cardiomyocyte (CM) loss or dysfunction. Although CMs have limited ability to regenerate, a large pool of non-myocytes, including cardiac fibroblasts (CFs), exis
Autor:
David R. Calabrese, Aleksandra M. Michalowski, John S. Schneekloth, Beverly A. Mock, Peter C. Gareiss, Elena C. Leon, Kenneth Felsenstein, Lindsey B. Saunders, Shuling Zhang, John K. Simmons
Publikováno v:
ACS Chemical Biology
The transcription factor MYC plays a pivotal role in cancer initiation, progression, and maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC. One attractive route to pharmacological inhibition of MYC has been the
Autor:
Ian J. Miller, Amy Pruden, Yanjun Ma, Linsey C. Marr, Jacob W. Metch, Eric P. Vejerano, Peter J. Vikesland, Elena C. Leon
Publikováno v:
Water Research. 68:87-97
As nanomaterials in consumer products increasingly enter wastewater treatment plants, there is concern that they may have adverse effects on biological wastewater treatment. Effects of silver (nanoAg), zero-valent iron (NZVI), titanium dioxide (nanoT
Autor:
Jin-Qiu Chen, Maxwell P. Lee, Jyoti Patel, Joy Gary, Snehal M. Gaikwad, Ke Zhang, John K. Simmons, Wendy Dubois, Benjamin J. Gamache, Aleksandra M. Michalowski, Jing Huang, Daniel Connors, Adriana Zingone, Nicholas Watson, Shuling Zhang, Ola Landgren, Elena C. Leon, Beverly A. Mock, Peter Ordentlich, W. Michael Kuehl
Publikováno v:
Molecular cancer therapeutics. 16(9)
Cancer treatments often require combinations of molecularly targeted agents to be effective. mTORi (rapamycin) and HDACi (MS-275/entinostat) inhibitors have been shown to be effective in limiting tumor growth, and here we define part of the cooperati
Publikováno v:
Environ. Sci.: Nano. 1:133-143
As the use of nanotechnology in consumer products continues to grow, it is inevitable that some nanomaterials will end up in the waste stream and will be incinerated. Through laboratory-scale incineration of paper and plastic wastes containing nanoma
Autor:
Zaw Phyo, David R. Calabrese, Elena C. Leon, Daniel Connors, John K. Simmons, Beverly A. Mock, Shuling Zhang, John S. Schneekloth, Snehal M. Gaikwad, Aleksandra M. Michalowski, Sayeh Gorjifard
Publikováno v:
Cancer Research. 77:194-194
MYC is deregulated in many malignancies and its aberrant expression is associated with tumorigenesis and tumor maintenance. We employed a therapeutic strategy to target both MYC transcription, and protein stability. Previously, we developed a small m
Autor:
John S. Schneekloth, David R. Calabrese, Lindsey B. Saunders, Kenneth Felsenstein, Wendy Dubois, Aleksandra M. Michalowski, Shuling Zhang, John K. Simmons, Elena C. Leon, Beverly A. Mock, Frank J. Gonzalez
Publikováno v:
Cancer Research. 76:322-322
MYC overexpression or amplification is commonly seen in a wide variety of tumor types, including multiple myeloma. Although MYC appears to be an important driver of the oncogenic phenotype, the helix-loop-helix topology, short half-life, and rapid re