Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Elena Braithwaite"'
Autor:
Lesley-Anne Furlong, Elena Braithwaite, Daiva Shetty, James Osterhout, Sree Rayavarapu, John R. Peters, Robert T. Dorsam
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 146(1)
This review highlights general toxicology concerns caused by formulation differences between generic and innovator drugs. It underscores the importance of a scientific, clinically oriented, evidence-based comparative safety evaluation procedure for g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2039c0382f02162036b52f0c15cce23d
https://pubmed.ncbi.nlm.nih.gov/26101235
https://pubmed.ncbi.nlm.nih.gov/26101235
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 424:207-219
DNA is frequently damaged by endogenous agents inside the cells. Some exogenous agents such as polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment and may thus contribute to the 'background' DNA damage in humans. DNA lesions are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8a57b0108f348daae76eae9ec76f05
https://doi.org/10.1016/s0027-5107(99)00020-2
https://doi.org/10.1016/s0027-5107(99)00020-2
Publikováno v:
Biochemistry. 42(38)
Benzo[a]pyrene is a potent environmental carcinogen, which can be metabolized in cells to the DNA damaging agent anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (anti-BPDE). We hypothesize that mutations induced by BPDE DNA adducts are mainly genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e5e4cb7c05720514a82bb4c689d422
https://pubmed.ncbi.nlm.nih.gov/14503875
https://pubmed.ncbi.nlm.nih.gov/14503875
Publikováno v:
Biochemistry. 38(9)
Excision repair of DNA is an important cellular response to DNA damage induced by radiation and many chemicals. In eukaryotes, base excision repair (BER) and nucleotide excision repair (NER) are two major excision repair pathways which are completed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53d5967e663645dbfc88dd9bffce4d0
https://pubmed.ncbi.nlm.nih.gov/10052932
https://pubmed.ncbi.nlm.nih.gov/10052932
Publikováno v:
Carcinogenesis. 19(7)
Polycyclic aromatic hydrocarbons (PAHs) are significant environmental pollutants representing an important risk factor in human cancers. DNA adducts formed by the ultimate carcinogens of PAHs are potentially toxic, mutagenic and carcinogenic. DNA rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddec65d22205a162e51c3676ab8b911
https://pubmed.ncbi.nlm.nih.gov/9683183
https://pubmed.ncbi.nlm.nih.gov/9683183