Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Elena Bogatcheva"'
Autor:
Gita N. Shankar, Helen Jaber Parish, Naveen K. Bejugam, Shravan K Mutyam, Elena Bogatcheva, Venkata M. Reddy
Publikováno v:
Pharmaceutical Development and Technology. 20:598-607
Tuberculosis (TB) is a common and often deadly infectious disease caused by strains of Mycobacteria. Development of new anti-tubercular drugs is essential to control the emergence and severity of multidrug-resistant TB.The objective of this study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3e78e8eb57e5c0886e1ae2771817f6
https://doi.org/10.3109/10837450.2014.908304
https://doi.org/10.3109/10837450.2014.908304
Publikováno v:
Drug Delivery Letterse. 1:150-158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d4dd032c53b034d357ebe3babbbf9f
https://doi.org/10.2174/2210303111101020150
https://doi.org/10.2174/2210303111101020150
Autor:
Elena Bogatcheva, Venkata M. Reddy, Boris Nikonenko, Leo Einck, Carol A. Nacy, Marina Protopopova
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:587-589
A phospholipid-based nanoemulsion formulation of SQ641 (SQ641-NE) was active against intracellular Mycobacterium tuberculosis in J774A.1 mouse macrophages, although SQ641 by itself was not. Intravenous (i.v.) SQ641-NE was cleared from circulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03e8ce3fd992fc54fc052cac7237365
https://doi.org/10.1128/aac.01254-13
https://doi.org/10.1128/aac.01254-13
Autor:
Ping Chen, Colleen F. Hanrahan, Elena Bogatcheva, Leo Einck, Carol A. Nacy, Marina Protopopova, Katherine A. Sacksteder, Jacqueline Gearhart
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:201-205
As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358 compounds on solid support using a pool-and-split technique and tested the resulting compounds for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19b7563755da093a0a83e8ecadaa0d3
https://doi.org/10.1016/j.bmcl.2009.10.135
https://doi.org/10.1016/j.bmcl.2009.10.135
Publikováno v:
Medicinal Chemistry. 3:301-316
The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b27b502eda4a3bce5242d3034945417
https://doi.org/10.2174/157340607780620626
https://doi.org/10.2174/157340607780620626
Autor:
Cirle A. Warren, Marina Protopopova, Glynis L. Kolling, Jae Hyun Shin, Andrew J. Phipps, Leo Einck, Elena Bogatcheva, Boris Nikonenko, John H. Moore, Edward J. van Opstal, Richard L. Guerrant
Publikováno v:
The Journal of antimicrobial chemotherapy. 71(5)
OBJECTIVES Clostridium difficile infection (CDI) is a primary cause of antibiotic-associated diarrhoeal illness. Current therapies are insufficient as relapse rates following antibiotic treatment range from 25% for initial treatment to 60% for treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3461d4d1915514bf7b953eac91ea79
https://pubmed.ncbi.nlm.nih.gov/26832756
https://pubmed.ncbi.nlm.nih.gov/26832756
Autor:
Rowena Samala, Leo Einck, Carol A. Nacy, Jacqueline Gearhart, Boris Nikonenko, Francis Barbosa, Colleen F. Hanrahan, Marina Protopopova, Ping Chen, Elena Bogatcheva
Publikováno v:
Journal of Medicinal Chemistry. 49:3045-3048
A diverse 5000-compound library was synthesized from commercially available diamines and screened for activity against Mycobacterium tuberculosis in vitro, revealing 143 hits with minimum inhibitory concentration (MIC) equal to or less than 12.5 micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f97e9b2411649cc50de1f773f20552
https://doi.org/10.1021/jm050948+
https://doi.org/10.1021/jm050948+
Autor:
Gladys de los Santos, Venkata M. Reddy, Leo Einck, Carol A. Nacy, Elena Bogatcheva, Colleen F. Hanrahan, Boris Nikonenko, Marina Protopopova, Francis Barbosa, Ping Chen
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
We recently reported that compounds created around a dipiperidine scaffold demonstrated activity against Mycobacterium tuberculosis (Mtb) (Bogatcheva, E.; Hanrahan, C.; Chen, P.; Gearhart, J.; Sacksteder, K.; Einck, L.; Nacy, C.; Protopopova, M. Bioo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae7b08106f79b09c2ab521509bd36a6
https://pubmed.ncbi.nlm.nih.gov/21807506
https://pubmed.ncbi.nlm.nih.gov/21807506
Autor:
Leo Einck, Carol A. Nacy, Venkata M. Reddy, Marina Protopopova, Tia Dubuisson, Elena Bogatcheva
Publikováno v:
The Journal of antimicrobial chemotherapy. 66(3)
Objectives: To extend capuramycin spectrum of activity beyond mycobacteria and improve intracellular drug activity. Methods: Three capuramycin analogues (SQ997, SQ922 and SQ641) were conjugated with different natural and unnatural amino acids or deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5959e41afbfd3a5e24845112649f7d
https://pubmed.ncbi.nlm.nih.gov/21186194
https://pubmed.ncbi.nlm.nih.gov/21186194
Autor:
Manju Y. Krishnan, Michael T. Collins, Venkata M. Reddy, Carol A. Nacy, Tia Dubuisson, Leo Einck, Elena Bogatcheva
Objectives: To determine antibacterial activity of capuramycin analogues SQ997, SQ922, SQ641 and RKS2244 against several non-tuberculous mycobacteria (NTM). Methods: In vitro antibiotic activities, i.e. MIC, MBC, rate of killing and synergistic inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f622e8089263aaf872680afcf826be
https://europepmc.org/articles/PMC2976629/
https://europepmc.org/articles/PMC2976629/
