Výsledky vyhledávání - "Elena Bichenkova"

Akademický článek

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

Autor: Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova

Publikováno v: Molecules, Vol 26, Iss 6, p 1732 (2021)

RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren

Externí odkaz: https://doaj.org/article/b6e2f145e1c94415a4b34c09e00a009c

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Akademický článek

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Autor: Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova

Publikováno v: Molecules, Vol 25, Iss 10, p 2459 (2020)

Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology. In 2017, for the first time we introduced miRNAses–miRNA-targeted c

Externí odkaz: https://doaj.org/article/541a1ba4d2404fb3bbf78b1f9a1ee7a8

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Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner

Autor: Olga Patutina, Daria Chiglintseva, Bahareh Amirloo, David Clarke, Svetlana Gaponova, Valentin Vlassov, Elena Bichenkova, Marina Zenkova

Publikováno v: Patutina, O A, Chiglintseva, D, Amirloo, B, Clarke, D, Gaponova, S, Vlassov, V V, Bichenkova, E & Zenkova, M 2022, ' Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner. ', International Journal of Molecular Sciences, vol. 23, no. 12, 6562, pp. 1-22 . https://doi.org/10.3390/ijms23126562
International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6562

The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuArg)2Gly]2 (B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9cce90f54181a6d2b2c9a131d7eca2
https://doi.org/10.3390/ijms23126562

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1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities

Autor: João, Lavrado, Alexandra, Paulo, Elena, Bichenkova, Kenneth T, Douglas, Rui, Moreira

Publikováno v: Magnetic resonance in chemistry : MRC. 50(3)

Knowledge of protonable sites and acid dissociation constants of cryptolepine derivatives having C-11 substituents containing two amino functionalities is of great importance to the understanding of the mechanism of their antimalarial action, which m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6222fd7765c81ea8affac8331078bac
https://pubmed.ncbi.nlm.nih.gov/22367848

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