Výsledky vyhledávání - "Elena Bellavista"

Akademický článek

Inflammaging and Cancer: A Challenge for the Mediterranean Diet

Autor: Rita Ostan, Catia Lanzarini, Elisa Pini, Maria Scurti, Dario Vianello, Claudia Bertarelli, Cristina Fabbri, Massimo Izzi, Giustina Palmas, Fiammetta Biondi, Morena Martucci, Elena Bellavista, Stefano Salvioli, Miriam Capri, Claudio Franceschi, Aurelia Santoro

Publikováno v: Nutrients, Vol 7, Iss 4, Pp 2589-2621 (2015)

Aging is considered the major risk factor for cancer, one of the most important mortality causes in the western world. Inflammaging, a state of chronic, low-level systemic inflammation, is a pervasive feature of human aging. Chronic inflammation incr

Externí odkaz: https://doaj.org/article/ce74f040466d4843947f6ac204d09335

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Akademický článek

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

Autor: Juliane Liepe, Hermann-Georg Holzhütter, Elena Bellavista, Peter M Kloetzel, Michael PH Stumpf, Michele Mishto

Publikováno v: eLife, Vol 4 (2015)

Proteasomal protein degradation is a key determinant of protein half-life and hence of cellular processes ranging from basic metabolism to a host of immunological processes. Despite its importance the mechanisms regulating proteasome activity are onl

Externí odkaz: https://doaj.org/article/34a4329b98af46c7a61b15d70d77c7a3

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Akademický článek

Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

Autor: Elena Bellavista, Aurelia Santoro, Daniela Galimberti, Cristoforo Comi, Fabio Luciani, Michele Mishto

Publikováno v: Autoimmune Diseases, Vol 2014 (2014)

The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune sy

Externí odkaz: https://doaj.org/article/3a1a6040dd19425d9c98d6059b9e58c8

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Akademický článek

Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness.

Autor: Maria Conte, Francesco Vasuri, Giovanni Trisolino, Elena Bellavista, Aurelia Santoro, Alessio Degiovanni, Ermanno Martucci, Antonia D'Errico-Grigioni, Daniela Caporossi, Miriam Capri, Andrea B Maier, Olivier Seynnes, Laura Barberi, Antonio Musarò, Marco V Narici, Claudio Franceschi, Stefano Salvioli

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e73709 (2013)

Human aging is associated with a progressive loss of muscle mass and strength and a concomitant fat accumulation in form of inter-muscular adipose tissue, causing skeletal muscle function decline and immobilization. Fat accumulation can also occur as

Externí odkaz: https://doaj.org/article/80e71afa65324cf89b579cb945f7de8e

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Akademický článek

Charting the NF-κB pathway interactome map.

Autor: Paolo Tieri, Alberto Termanini, Elena Bellavista, Stefano Salvioli, Miriam Capri, Claudio Franceschi

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32678 (2012)

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor κB (NF-κB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hund

Externí odkaz: https://doaj.org/article/baa0212e6fc343ef883e0cef425fbcec

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Akademický článek

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12037 (2010)

BackgroundAlzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused by defects in mitochondrial oxidative phosphorylation. Given the funda

Externí odkaz: https://doaj.org/article/9894e1651792487a9699a941862fe2c6

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Akademický článek

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9287 (2010)

BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the prod

Externí odkaz: https://doaj.org/article/4cb4cbf2336142ff9d2394e21649e691

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Recovery from 6-month spaceflight at the International Space Station: Muscle-related stress into a proinflammatory setting

Publikováno v: The FASEB Journal
The FASEB journal 33 (2019): 5168–5180.. doi:10.1096/fj.201801625R
info:cnr-pdr/source/autori:Miriam Capri 1,2, Cristina Morsiani 1,2, Aurelia Santoro 1,2, Manuela Moriggi 3,4, Maria Conte 1,2, Morena Martucci 1,2, Elena Bellavista 1, Cristina Fabbri 1,2, Enrico Giampieri 2,5, Kirsten Albracht 6,7, Martin Flück 8, Severin Ruoss 8, Lorenza Brocca 9, Monica Canepari 9, Emanuela Longa 10, Irene Di Giulio 11, Roberto Bottinelli 9,12, Paolo Cerretelli 3,4, Stefano Salvioli 1,2, Cecilia Gelfi 13,14, Claudio Franceschi 15, Marco Narici 16, and Jörn Rittweger 17,18./titolo:Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting./doi:10.1096%2Ffj.201801625R/rivista:The FASEB journal/anno:2019/pagina_da:5168/pagina_a:5180./intervallo_pagine:5168–5180./volume:33

The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6-mo International Space Station mission, has demonstrated the substantial muscle wasting and weakness, along with disruption of muscle's oxidative metabolism. The present wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2d87dbcb4b5ebf9779a3690a8566b
http://hdl.handle.net/11577/3315443

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Identification of miR-31-5p, miR-141-3p, miR-200c-3p, and GLT1 as human liver aging markers sensitive to donor-recipient age-mismatch in transplants

Publikováno v: Aging cell (Online) 16 (2017): 262–272. doi:10.1111/acel.12549
info:cnr-pdr/source/autori:Capri, Miriam; Olivieri, Fabiola; Lanzarini, Catia; Remondini, Daniel; Borelli, Vincenzo; Lazzarini, Raffaella; Graciotti, Laura; Albertini, Maria Cristina; Bellavista, Elena; Santoro, Aurelia; Biondi, Fiammetta; Tagliafico, Enrico; Tenedini, Elena; Morsiani, Cristina; Pizza, Grazia; Vasuri, Francesco; D'Errico, Antonietta; Dazzi, Alessandro; Pellegrini, Sara; Magenta, Alessandra; D'Agostino, Marco; Capogrossi, Maurizio C.; Cescon, Matteo; Rippo, Maria Rita; Procopio, Antonio Domenico; Franceschi, Claudio; Grazi, Gian Luca/titolo:Identification of miR-31-5p, miR-141-3p, miR-200c-3p, and GLT1 as human liver aging markers sensitive to donor-recipient age-mismatch in transplants/doi:10.1111%2Facel.12549/rivista:Aging cell (Online)/anno:2017/pagina_da:262/pagina_a:272/intervallo_pagine:262–272/volume:16
Aging Cell

Summary To understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged 12–92 years before transplants and in 11 biopsies after transplants with high donor–reci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113bcfa9384ef072560e0ae1030af24a
http://hdl.handle.net/11585/575227

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Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis

Publikováno v: Dianzani, C, Bellavista, E, Liepe, J, Verderio, C, Martucci, M, Santoro, A, Chiocchetti, A, Gigliotti, C L, Boggio, E, Ferrara, B, Riganti, L, Keller, C, Janek, K, Niewienda, A, Fenoglio, C, Sorosina, M, Cantello, R, Kloetzel, P M, Stumpf, M P H, Paul, F, Ruprecht, K, Galimberti, D, Martinelli Boneschi, F, Comi, C, Dianzani, U & Mishto, M 2017, ' Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis ', Scientific Reports, vol. 7, no. 1, 43718 . https://doi.org/10.1038/srep43718
Scientific Reports

Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702b3e703e529a2f0b1b4d71ed00f431
http://hdl.handle.net/11585/592344

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