Tocilizumab in refractory giant cell arteritis. Monotherapy versus combined therapy with conventional immunosuppressive drugs. Observational multicenter study of 134 patients

Autor: Noelia Alvarez-Rivas, Francisca Sivera, Susana Romero-Yuste, Carles Galisteo, Santos Castañeda, Monica Calderón-Goercke, Elena Becerra-Fernández, Ignacio Villa, José L. Hernández, Vicente Aldasoro, Diana Prieto-Peña, Eugenio de Miguel, Rafael Melero, Miguel A. González-Gay, Ricardo Blanco, Eva Perez-Pampin, Catalina Gomez-Arango, Javier Narváez, Marcelino Revenga, Clara Moriano

Publikováno v: Seminars in arthritis and rheumatism. 51(2)

Objective To compare the efficacy and safety of TCZ in monotherapy (TCZMONO) vs. combined with conventional immunosuppressive drugs (TCZCOMBO) in Giant Cell Arteritis (GCA) in a clinical practice scenario. Methods Multicenter study of 134 patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae4cc7d724737323cb1caaa1fc822ae
https://pubmed.ncbi.nlm.nih.gov/33607384

FRI0277 ISCHEMIC AND SYSTEMIC SYMPTOMS IN GIANT CELL ARTERITIS PATIENTS, RESPONSE TO TOCILIZUMAB

Autor: Sara Manrique Arija, Pau Lluch, Alejandro Olivé, María Álvarez del Buergo, J. Luis Hernández, Clara Moriano, Juan Carlos Nieto, Javier Loricera, Arantxa Conesa, Marcelino Revenga, Elena Aurrecoechea, Rafael Melero, Vanesa Calvo-Río, Paloma Vela-Casasempere, Miguel A. González-Gay, C. Hidalgo, Catalina Gomez-Arango, Elena Becerra-Fernández, Raquel Dos-Santos, Antonio García, Diana Prieto-Peña, Francisca Sivera, María Varela-García, Carles Galisteo, Natalia Palmou-Fontana, Santos Castañeda, Beatriz Arca, I. Villa-Blanco, Montserrat Corteguera, Eva Salgado-Pérez, A. Humbría, Luisa Marena Rojas, Ricardo Blanco, Norberto Ortego, Roser Solans-Laqué, Francisco Ortiz-Sanjuán, Eugenio de Miguel, Eva Galindez, José Andrés Román-Ivorra, Alfonso Corrales, Enrique Raya, Carlos Vázquez, Carmen Torres-Martín, Ángel García-Manzanares, Francisco Navarro, J Francisco, Monica Calderón-Goercke, Noelia Alvarez-Rivas, Susana Romero-Yuste, Carmen Ordas-Calvo, Carlos Fernández-López, N. Fernández-Llanio, Carmen Larena, Sabela Fernández, Eva Perez-Pampin, Cristina Luna-Gomez, Carmen González-Vela, Vicente Aldasoro, Javier Narváez, Toyos Sáenz de Miera

Publikováno v: Poster Presentations.

Background In Giant Cell Arteritis (GCA) two dominant cytokine clusters have been linked to disease activity, IL-6 – IL-17 axis (Th17) and IL-12 – IFN γ axis (Th1). The first one related to systemic symptoms and the second route responsible for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1af56b2bb22928fb7ae8931b4ea31e4f
https://doi.org/10.1136/annrheumdis-2019-eular.2230

AB0577 TOCILIZUMAB IN GIANT CELL ARTERITIS. ROUTE OF ADMINISTRACION: INTRAVENOUS OR SUBCUTANEOUS

Autor: Roser Solans-Laqué, Susana Romero-Yuste, P. Vela-Casasempere, Raquel Dos-Santos, Marcelino Revenga, C. Hidalgo, Sara Manrique Arija, Carmen Larena, Elena Aurrecoechea, Miguel A. González-Gay, I. Villa-Blanco, Noelia Alvarez-Rivas, Beatriz Arca, Sabela Fernández, Carmen Ordas-Calvo, Ricardo Blanco, Eva Salgado-Pérez, Enrique Raya, María Álvarez del Buergo, Santos Castañeda, María Varela-García, Carles Galisteo, Juan Carlos Nieto, Francisco Navarro, Catalina Gomez-Arango, Toyos Sáenz de Miera, Eugenio de Miguel, Alfonso Corrales, Cristina Luna-Gomez, Ángel García-Manzanares, Francisco Ortiz-Sanjuán, Carmen Torres-Martín, A. Humbría, J Francisco, José Andrés Román-Ivorra, Clara Moriano, Luisa Marena Rojas, Vanesa Calvo-Río, Alejandro Olive, Rafael Melero, Antonio García, Elena Becerra-Fernández, Norberto Ortego, Monica Calderón-Goercke, Francisca Sivera, J. Luis Hernández, Montserrat Corteguera, Carlos Fernández-López, N. Fernández-Llanio, Natalia Palmou-Fontana, Diana Prieto-Peña, Pau Lluch, Carlos Vázquez, Javier Loricera, Arantxa Conesa, Javier Narváez, Eva Perez-Pampin, Carmen González-Vela, Vicente Aldasoro, Eva Galindez

Publikováno v: Abstracts Accepted for Publication.

Background Recently, based on the GiACTA trial results, weekly subcutaneous Tocilizumab (TCZ) has been approved for the treatment of Giant Cell Arteritis (GCA). It has showed to be effective and safety. Objectives Our aim was to compare the efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e4531a207704aba148ec0f374ac103
https://doi.org/10.1136/annrheumdis-2019-eular.2226

Tocilizumab in giant cell arteritis. Observational, open-label multicenter study of 134 patients in clinical practice

Autor: C. Hidalgo, María Varela-García, Carles Galisteo, Santos Castañeda, Susana Romero-Yuste, Noelia Alvarez-Rivas, Raquel Dos Santos, Carmen González-Vela, José L. Hernández, Rafael Melero, Carlos Fernández-López, Sabela Fernández, Francisco Ortiz-Sanjuán, Vicente Aldasoro, Clara Moriano, N. Fernández-Llanio, Paloma Vela, Francisca Sivera, Alejandro Olivé-Marqués, Carmen Ordas-Calvo, Eva Galíndez-Agirregoikoa, Alfonso Corrales, Enrique Raya, Ricardo Blanco, Eugenio de Miguel, Diana Prieto-Peña, Carlos Vázquez, Vanesa Calvo-Río, Elena Aurrecoechea, Carmen Larena, Ángel García-Manzanares, Miguel A. González-Gay, Elena Becerra-Fernández, Marcelino Revenga, Antonio García, Eva Perez-Pampin, María Álvarez del Buergo, José Andrés Román-Ivorra, Natalia Palmou-Fontana, Juan Carlos Nieto, Luisa Marena-Rojas, Montserrat Corteguera, F. Javier Toyos-Sáenz de Miera, Cristina Luna-Gomez, Sara Manrique-Arija, Catalina Gomez-Arango, Monica Calderón-Goercke, Roser Solans-Laqué, Carmen Torres-Martín, Beatriz Arca, Eva Salgado-Pérez, Ignacio Villa, Norberto Ortego, Javier Narváez, A. Humbría, Pau Lluch, Francisco Navarro, Javier Loricera, Arantxa Conesa

Publikováno v: SEMINARS IN ARTHRITIS AND RHEUMATISM
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Semin Arthritis Rheum. 2019 Aug;49(1):126-135
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

Objective: Tocilizumab (TCZ) has shown efficacy in clinical trials on giant cell arteritis (GCA). Real-world data are scarce. Our objective was to assess efficacy and safety of TCZ in unselected patients with GCA in clinical practice Methods: Observa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21d5a02db953c023245fb1b796fa8c9
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=7994

OP0033 OPTIMIZATION OF TOCILIZUMAB THERAPY IN GIANT CELL ARTERITIS. A MULTICENTER REAL-LIFE STUDY OF 134 PATIENTS

Autor: Susana Romero-Yuste, Clara Moriano, E. Salgado-Pérez, Noelia Alvarez-Rivas, P. Vela-Casasempere, Beatriz Arca, Cristina Luna-Gomez, E. De Miguel, Fátima Navarro, M. Álvarez del Buergo, José Andrés Román-Ivorra, Francisca Sivera, Pau Lluch, M. A. González-Gay, Arantxa Conesa, Monica Calderón-Goercke, C. Torres-Martín, A. García, Roman Blanco, Rafael Melero, Marcelino Revenga, Carlos Fernández-López, N. Fernández-Llanio, S. Castañeda, Candelario Vázquez, Josefina Hernández, Carlos Galisteo, Elena Becerra-Fernández, Enrique Raya, Diana Prieto-Peña, J.A. Narváez, E. Galindez, S. Manrique Arija, C. Hidalgo, I. Villa-Blanco, L. Marena Rojas, C. Ordas-Calvo, Vicente Aldasoro, Águeda Prior-Español, A. Olivé, Juan Carlos Nieto, Eva Perez-Pampin, Catalina Gomez-Arango, Roser Solans-Laqué, F. J. Toyos Sáenz de Miera

Publikováno v: Annals of the Rheumatic Diseases. 79:23.1-23

Background:Tocilizumab (TCZ) is the only biological agent approved in Giant Cell Arteritis (GCA). There is general agreement on the initial and the standard maintenance dose of TCZ. However, information on duration and optimization of TCZ in GCA is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7f9011b7cdb7ce3046d7b3a28194890
https://doi.org/10.1136/annrheumdis-2020-eular.2574