Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elena Balkanska-Sinclair"'
Autor:
Drake S. Edwards, Rohin Maganti, Jarred P. Tanksley, Jie Luo, James J.H. Park, Elena Balkanska-Sinclair, Jinjie Ling, Scott R. Floyd
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108166- (2020)
Summary: Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription and replication
Externí odkaz:
https://doaj.org/article/596d35d5db88409380270149452bd9ac
Autor:
Fred C. Lam, Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B Yaffe, Scott R Floyd, Paula T Hammond
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The blood-brain barrier often limits effective delivery of treatments for glioblastoma . In this study, the authors develop transferrin-functionalized nanoparticles able to traverse the intact blood-brain barrier and deliver combination temozolomide
Externí odkaz:
https://doaj.org/article/7b4a074c2e9340cbb338535cafd8e632
Autor:
Paula T. Hammond, Tu-Lan Vu Han, Jeffrey Wyckoff, Scott R. Floyd, Amanda Maffa, Fred C. Lam, Michael B. Yaffe, Elena Balkanska-Sinclair, Stephen W. Morton, Mun Kyung Hwang
Effective treatment of CNS tumors is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed nanoparticles (NPs) that can be functionalized with ligands, such as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd47758211b2670710ced4e78409639
https://europepmc.org/articles/PMC6216767/
https://europepmc.org/articles/PMC6216767/
Autor:
Jinjie Ling, Elena Balkanska-Sinclair, Jie Luo, Scott R. Floyd, Drake S. Edwards, James J. H. Park, Rohin Maganti, Jarred P. Tanksley
Publikováno v:
Cell Reports
Cell Reports, Vol 32, Iss 12, Pp 108166-(2020)
Cell Reports, Vol 32, Iss 12, Pp 108166-(2020)
Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription and replication machiner
Autor:
Fred C Lam, Stephen W Morton, Jeffrey Wyckoff, Amanda Maffa, Elena Balkanska-Sinclair, Scott R Floyd, Michael B Yaffe, Paula T Hammond
Effective treatment for gliomablastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin functionalized nanoparticle (Tf-NP) that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712cae20e5a4ce8ed3f0d8f20f1dd8a9
https://europepmc.org/articles/PMC5693072/
https://europepmc.org/articles/PMC5693072/
Autor:
Paula T. Hammond, Elena Balkanska-Sinclair, Scott R. Floyd, Fred C. Lam, Jeffrey Wyckoff, Amanda Maffa, Stephen W. Morton
Publikováno v:
Neuro-Oncology. 19:vi73-vi73
Effective treatment for glioblastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can de
Autor:
Sheila Cummings Sm Macri, Elizabeth Curran, Rosemary Santos, Miguel Sena-Esteves, Diane Golebiowski, Julie G. Pilitsis, Elizabeth Hutto, Wael F. Asaad, Keiko Y. Petrosky, Nina Bishop, Kajo van der Marel, Matthew J. Gounis, Elena Balkanska-Sinclair, Douglas R. Martin
Publikováno v:
Molecular Therapy. 23:S283
The GM2 gangliosidoses are lysosomal storage disorders that encompass both Tay-Sachs and Sandhoff diseases. These diseases are associated with deficiencies in the lysosomal enzyme β-N-acetylhexosaminidase (HexA). These deficiencies result in accumul