Maternal Hypoxia Increases the Excitability of Neurons in the Entorhinal Cortex and Dorsal Hippocampus of Rat Offspring

Autor: Dmitry V. Amakhin, Elena B. Soboleva, Tatiana Yu. Postnikova, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Daria S. Kalinina, Dmitrii S. Vasilev, Aleksey V. Zaitsev

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Prenatal hypoxia is a widespread condition that causes various disturbances in later life, including aberrant central nervous system development, abnormalities in EEG rhythms, and susceptibility to seizures. Hypoxia in rats on the 14th day of embryog

Externí odkaz: https://doaj.org/article/91598d2f1b124ec9bc0ee2716dd11318

Seizure-Induced Potentiation of AMPA Receptor-Mediated Synaptic Transmission in the Entorhinal Cortex

Autor: Dmitry V. Amakhin, Elena B. Soboleva, Julia L. Ergina, Sergey L. Malkin, Anton V. Chizhov, Aleksey V. Zaitsev

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Excessive excitation is considered one of the key mechanisms underlying epileptic seizures. We investigated changes in the evoked postsynaptic responses of medial entorhinal cortex (ERC) pyramidal neurons by seizure-like events (SLEs), using the modi

Externí odkaz: https://doaj.org/article/ace239f64a2c4cbca05ca26a577757b5

Modulation of seizure-like events by the small conductance and ATP-sensitive potassium ion channels

Autor: Elena B. Soboleva, Dmitry V. Amakhin, Denis S. Sinyak, Aleksey V. Zaitsev

Publikováno v: Biochemical and biophysical research communications. 623

Potassium ion channels are extensively involved in the regulation of epileptic seizures. The small conductance calcium-sensitive potassium channels (SK channels) and ATP-sensitive potassium (K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ca3756ccc1554c14e86269ef223476
https://pubmed.ncbi.nlm.nih.gov/35878426

Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

Autor: Tatyana Y. Postnikova, Georgy P. Diespirov, Dmitry V. Amakhin, Elizaveta N. Vylekzhanina, Elena B. Soboleva, Aleksey V. Zaitsev

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13355
International Journal of Molecular Sciences, Vol 22, Iss 13355, p 13355 (2021)

Status epilepticus (SE) causes persistent abnormalities in the functioning of neuronal networks, often resulting in worsening epileptic seizures. Many details of cellular and molecular mechanisms of seizure-induced changes are still unknown. The lith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74da0fa75c2acc1ca5bbace73ee62a16
http://europepmc.org/articles/PMC8705146

Short-Term Epileptiform Activity Potentiates Excitatory Synapses but Does Not Affect Intrinsic Membrane Properties of Pyramidal Neurons in the Rat Hippocampus In Vitro

Autor: Dmitry V. Amakhin, Aleksey V. Zaitsev, Elena B. Soboleva, Julia L. Ergina, Tatyana Y. Postnikova

Publikováno v: Biomedicines
Volume 9
Issue 10
Biomedicines, Vol 9, Iss 1374, p 1374 (2021)

Even brief epileptic seizures can lead to activity-dependent structural remodeling of neural circuitry. Animal models show that the functional plasticity of synapses and changes in the intrinsic excitability of neurons can be crucial for epileptogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3526e1f597224ef97142b89ddb35ecf