The Lon protease is essential for full virulence in Pseudomonas aeruginosa.

Autor: Elena B M Breidenstein, Laure Janot, Janine Strehmel, Lucia Fernandez, Patrick K Taylor, Irena Kukavica-Ibrulj, Shaan L Gellatly, Roger C Levesque, Joerg Overhage, Robert E W Hancock

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49123 (2012)

Pseudomonas aeruginosa PAO1 lon mutants are supersusceptible to ciprofloxacin, and exhibit a defect in cell division and in virulence-related properties, such as swarming, twitching and biofilm formation, despite the fact that the Lon protease is not

Externí odkaz: https://doaj.org/article/f069355e91584cdea25c83cadc7047d6

Two Isoforms of Clp Peptidase in Pseudomonas aeruginosa Control Distinct Aspects of Cellular Physiology

Autor: Gina D. Mawla, Elena B. M. Breidenstein, Cesar de la Fuente-Nunez, Fany Reffuveille, Robert E. W. Hancock, Tania A. Baker, Branwen M. Hall

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2017, 199 (3), ⟨10.1128/JB.00568-16⟩

Caseinolytic peptidases (ClpPs) regulate diverse aspects of cellular physiology in bacteria. Some species have multiple ClpPs, including the opportunistic pathogen Pseudomonas aeruginosa , in which there is an archetypical isoform, ClpP1, and a secon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af4aa9c131f8ab39a2cf8ce9fca2762
https://hal.archives-ouvertes.fr/hal-02528662

Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

Autor: Elena B. M. Breidenstein, Diana Song, Robert E. W. Hancock, Lucía Fernández

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:1128-1132

Pseudomonas aeruginosa possesses complex regulatory networks controlling virulence and survival under adverse conditions, including antibiotic pressure, which are interconnected and share common regulatory proteins. Here, we screen a panel of 13 muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baacea02b141c6ea784960fd15add07
https://doi.org/10.1128/aac.05336-11

Anti-Biofilm and Immunomodulatory Activities of Peptides That Inhibit Biofilms Formed by Pathogens Isolated from Cystic Fibrosis Patients

Autor: Fany Reffuveille, Ya Shen, Markus Haapasalo, Zhejun Wang, Melissa Elliott, David P. Speert, Elena B. M. Breidenstein, Lucy Jiang, Sarah C. Mansour, Cesar de la Fuente-Nunez, Shauna L. Reckseidler-Zenteno, Robert E. W. Hancock

Publikováno v: Antibiotics
Antibiotics, Vol 3, Iss 4, Pp 509-526 (2014)
Antibiotics, MDPI, 2014, 3 (4), pp.509-526. ⟨10.3390/antibiotics3040509⟩
Volume 3
Issue 4
Pages 509-526

Cystic fibrosis (CF) patients often acquire chronic respiratory tract infections due to Pseudomonas aeruginosa and Burkholderia cepacia complex (Bcc) species. In the CF lung, these bacteria grow as multicellular aggregates termed biofilms. Biofilms d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5337ef258056d995bf6bd70a15f1eafe
https://pubmed.ncbi.nlm.nih.gov/26221537

Armand-Frappier outstanding student award -- role of ATP-dependent proteases in antibiotic resistance and virulence

Autor: Elena B. M. Breidenstein, Robert E. W. Hancock

Publikováno v: Canadian journal of microbiology. 59(1)

ATP-dependent proteases are found in nearly all living organisms and are known to play important roles in protein quality control, including protein degradation and protein refolding. ATP-dependent proteases have been well characterized in Escherichi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d60419f074638a0b286d0cc4486446e
https://pubmed.ncbi.nlm.nih.gov/23391222