Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Elena B, Pasquale"'
Autor:
Shilpa Bhatia, Diemmy Nguyen, Laurel B. Darragh, Benjamin Van Court, Jaspreet Sharma, Michael W. Knitz, Miles Piper, Sanjana Bukkapatnam, Jacob Gadwa, Thomas E. Bickett, Shiv Bhuvane, Sophia Corbo, Brian Wu, Yichien Lee, Mayumi Fujita, Molishree Joshi, Lynn E. Heasley, Robert L. Ferris, Olga Rodriguez, Christopher Albanese, Mohit Kapoor, Elena B. Pasquale, Sana D. Karam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
EphrinB2 and its receptor EphB4 are highly expressed in head and neck squamous cell carcinoma (HNSCC) and disrupting EphB4-ephrinB2 interaction generates sub-optimal outcomes. Here, compartmental targeting of EphB4 and ephrinB2 in HNSCC cancer cell a
Externí odkaz:
https://doaj.org/article/f51f6287a90c4406bc2348a5db38a8b9
Autor:
Bernhard C. Lechtenberg, Marina P. Gehring, Taylor P. Light, Christopher R. Horne, Mike W. Matsumoto, Kalina Hristova, Elena B. Pasquale
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Eph receptor tyrosine kinases and their ephrin ligands mediate cell-cell communication. Here, the authors assess the structure and dynamics of the EphA2 intracellular region and uncover complex effects of phosphorylation within the linker region betw
Externí odkaz:
https://doaj.org/article/4e61813b18fe47238560b7007035a60e
Autor:
Maricel Gomez-Soler, Marina P. Gehring, Bernhard C. Lechtenberg, Elmer Zapata-Mercado, Alyssa Ruelos, Mike W. Matsumoto, Kalina Hristova, Elena B. Pasquale
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103870- (2022)
Summary: The EphA2 receptor tyrosine kinase activates signaling pathways with different, and sometimes opposite, effects in cancer and other pathologies. Thus, highly specific and potent biased ligands that differentially control EphA2 signaling resp
Externí odkaz:
https://doaj.org/article/e33b90ba351d4d81933f32539fdaf4d9
Publikováno v:
ChemSystemsChem. 4(5)
Lipid rafts are known as highly ordered lipid domains that are enriched in saturated lipids such as the ganglioside GM1. While lipid rafts are believed to exist in cells and to serve as signaling platforms through their enrichment in signaling compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9beeeea8df579f83a5a1a91795461c2b
https://pubmed.ncbi.nlm.nih.gov/36337751
https://pubmed.ncbi.nlm.nih.gov/36337751
Autor:
Keiran S.M. Smalley, Hussein Tawbi, Darrin Stuart, Geoffrey T. Gibney, Sarah Sloot, Friedegund Meier, John M. Kirkwood, Uma N. Rao, Alejandro Villagra, Elena B. Pasquale, Jane L. Messina, Vernon K. Sondak, Keith T. Flaherty, Hensin Tsao, Jobin K. John, Inna V. Fedorenko, John M. Koomen, Bin Fang, Meghna Das Thakur, Kim H.T. Paraiso
Supplemental Figure 1. Characterization of the resistant cell lines. Supplemental Figure 2. Quantification of the cell invasion from figure 1D. Supplemental Figure 3. Model showing ligand dependent and independent ephrin signaling. Supplemental Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dce9c47489ab84a6f2137134ee8395f
https://doi.org/10.1158/2159-8290.22530725
https://doi.org/10.1158/2159-8290.22530725
Autor:
Sana D. Karam, Elena B. Pasquale, Eric T. Clambey, Antonio Jimeno, Xiao-Jing Wang, Natalie J. Serkova, David Raben, Benjamin Van Court, Adam C. Mueller, Andy V. Phan, Dallin Milner, Laurel B. Darragh, Shelby Lennon, Ayman Oweida, Shilpa Bhatia
Total number of CD4+T cells remain unchanged following Control-Fc and ephrin-B2-Fc (20 μg/ml) treatment of T cells (A). Correlation analysis was also performed between TGF-β and EFNB2, EphB4 on R2 analysis platform (B-C). Alterations of cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078b77d89ee423be4cb90645ba5b3b4
https://doi.org/10.1158/0008-5472.22418526.v1
https://doi.org/10.1158/0008-5472.22418526.v1
Autor:
Sana D. Karam, Elena B. Pasquale, Eric T. Clambey, Antonio Jimeno, Xiao-Jing Wang, Natalie J. Serkova, David Raben, Benjamin Van Court, Adam C. Mueller, Andy V. Phan, Dallin Milner, Laurel B. Darragh, Shelby Lennon, Ayman Oweida, Shilpa Bhatia
Mice implanted with PDX tumors show significantly reduced uptake of supra-paramagnetic iron oxide nanoparticles (SPIO) in the combined sEphB4-HSA and RT group compared to the groups treated with RT alone or with sEphB4-HSA alone in DCE-MRI imaging (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40e96ae3a2c0a71d4425ecd0cdc09bd
https://doi.org/10.1158/0008-5472.22418520.v1
https://doi.org/10.1158/0008-5472.22418520.v1
Autor:
Sana D. Karam, Elena B. Pasquale, Eric T. Clambey, Antonio Jimeno, Xiao-Jing Wang, Natalie J. Serkova, David Raben, Benjamin Van Court, Adam C. Mueller, Andy V. Phan, Dallin Milner, Laurel B. Darragh, Shelby Lennon, Ayman Oweida, Shilpa Bhatia
Immunofluorescence staining showing co-expression of EphB4 and pan-keratin in Ly2 tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9472c5e39fe6656ff7396b0c200fd318
https://doi.org/10.1158/0008-5472.22418541
https://doi.org/10.1158/0008-5472.22418541
Autor:
Sana D. Karam, Elena B. Pasquale, Eric T. Clambey, Antonio Jimeno, Xiao-Jing Wang, Natalie J. Serkova, David Raben, Benjamin Van Court, Adam C. Mueller, Andy V. Phan, Dallin Milner, Laurel B. Darragh, Shelby Lennon, Ayman Oweida, Shilpa Bhatia
IHC staining confirming expression of ephrin-B2 in areas stained with fibroblast-expressing α-Smooth muscle actin (α-SMA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67afcb005592eb6d766d5fd4291f1515
https://doi.org/10.1158/0008-5472.22418538.v1
https://doi.org/10.1158/0008-5472.22418538.v1
Autor:
Sana D. Karam, Elena B. Pasquale, Eric T. Clambey, Antonio Jimeno, Xiao-Jing Wang, Natalie J. Serkova, David Raben, Benjamin Van Court, Adam C. Mueller, Andy V. Phan, Dallin Milner, Laurel B. Darragh, Shelby Lennon, Ayman Oweida, Shilpa Bhatia
Blockade of EphB4-ephrin-B2 interaction combined with RT suppresses tumor growth in HNSCC tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580152e3bfb523bc3b498a5942f601c4
https://doi.org/10.1158/0008-5472.22418523
https://doi.org/10.1158/0008-5472.22418523