Výsledky vyhledávání - "Elena Anahi Bignante"

Akademický článek

Aβ Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of Aβ42 Through Go/Gβγ Signaling

Autor: Magdalena Antonino, Paula Marmo, Carlos Leandro Freites, Gonzalo Emiliano Quassollo, Maria Florencia Sánchez, Alfredo Lorenzo, Elena Anahi Bignante

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Alzheimer’s disease (AD) is characterized by the deposition of aggregated species of amyloid beta (Aβ) in the brain, which leads to progressive cognitive deficits and dementia. Aβ is generated by the successive cleavage of the amyloid precursor p

Externí odkaz: https://doaj.org/article/aa0b30d2e94f47d0a74aede2dc77a3c6

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Synthesis and pharmacological evaluation of pyrazolo[4,3-c]quinolinones as high affinity GABAA-R ligands and potential anxiolytics

Autor: Elizabeth L. Moyano, Elena Anahi Bignante, Marisa Juana Lopez Rivilli, María A. Perillo, Anahi del Valle Turina, Margarita C. Briñón, Victor Hugo Cena Molina

Publikováno v: Bioorganic & Medicinal Chemistry. 26:3967-3974

The synthesis, in vitro ligand binding study and in vivo Elevated Plus Maze test (EPM) of a series of pyrazolo[4,3-c]quinolin-3-ones (PQs) are reported. Multistep synthesis of PQs started from anilines and diethyl 2-(ethoxymethylene)malonate to give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7906d0bc6ce0559d24674a7c134cd5ca
https://doi.org/10.1016/j.bmc.2018.06.021

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Fear-context association during memory retrieval requires input from granular to dysgranular retrosplenial cortex

Autor: Elena Anahi Bignante, Alfredo Lorenzo, Soledad de Olmos, Eric L. Sigwald

Publikováno v: Neurobiology of learning and memory. 163

The contribution of the granular (area 29, A29) and dysgranular (area 30, A30) subdivisions of the retrosplenial cortex (RSC) to contextual fear memory (CFM) retrieval remains elusive. Here, intact and orchiectomized (ORC) male rats received an intra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27925fe9f3cac37994a9b28b3e269715
https://pubmed.ncbi.nlm.nih.gov/31201928

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APP signaling in Alzheimer's disease

Autor: Alfredo Lorenzo, Elena Anahi Bignante

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Aging (Albany NY)

A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter of debate, in the last tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b52b000c9114e6afc989d833769f715
https://www.aging-us.com/article/101641/text

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APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models

Autor: Nicolás Eric Ponce, Elena Anahi Bignante, Gustavo Pigino, Alfredo Lorenzo, Mariano Martín Boccia, J. Millan, Florencia Heredia, Juliana Musso, Nibaldo C. Inestrosa, Maria del Carmen Krawczyk

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the mechanism of Aβ-induced de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b77b9997f15af1ab403b99776f1dc0a
https://www.sciencedirect.com/science/article/pii/S0197458017304086

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Erk activation in the amygdala and hippocampus induced by fear conditioning in ethanol withdrawn rats: Modulation by mk-801

Autor: Irene Delia Martijena, María Eugenia Bertotto, Elena Anahi Bignante, Silvana Vanesa Gorosito, Noelia Martina Maldonado, María Julia Cambiasso, Victor A. Molina

Publikováno v: European Neuropsychopharmacology. 21:892-904

The extracellular signal-regulated kinase (ERK) pathway, which can be activated by NMDA receptor stimulation, is involved in fear conditioning and drug addiction. We have previously shown that withdrawal from chronic ethanol administration facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff0d567e7693d677f31208424b3b9f6
https://doi.org/10.1016/j.euroneuro.2011.01.001

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Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress

Autor: Estela Cecilia Mlewski, Elena Anahi Bignante, Pablo A. Rodríguez Manzanares, Victor A. Molina, D. F. Bussolino, Gabriela Paglini, María Eugenia Bertotto

Publikováno v: European Neuropsychopharmacology. 18:578-588

The aim of the present study was to evaluate whether the activation of Cdk5, a protein that has been suggested to participate in higher cognitive functions, is required for the onset of a sensitized anxiety-related behavior induced by stress. The exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfcb0a479eb42ce708901fa01a9dad7
https://doi.org/10.1016/j.euroneuro.2008.02.007

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Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease

Autor: Florencia Heredia, Elena Anahi Bignante, Alfredo Lorenzo, Gerardo Morfini

Publikováno v: Neurobiology of aging. 34(11)

A role of amyloid b (Ab) peptide aggregation and deposition in Alzheimer’s disease (AD) pathogenesis is widely accepted. Significantly, abnormalities induced by aggregated Ab have been linked to synaptic and neuritic degeneration, consistent with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858c40f64b2e4b2c968008f0fa1eabcd
https://pubmed.ncbi.nlm.nih.gov/23714735

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Previous stress exposure enhances both anxiety-like behaviour and p35 levels in the basolateral amygdala complex: modulation by midazolam

Autor: Victor A. Molina, Gabriela Paglini, Elena Anahi Bignante

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 20(6)

Stress exposure induces long lasting neurobiological changes in selected brain areas, which could be associated with the emergence of negative emotional responses. In the present study, previously restrained animals exhibited excessive anxiety one da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c451e0e9bb9ba7973112cf774d6a7ca
https://pubmed.ncbi.nlm.nih.gov/20223640

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Changes in hippocampal arc protein expression and synaptic plasticity by the presentation of contextual cues linked to drug experience

Autor: Oscar A. Ramirez, Elena Anahi Bignante, Romina Soledad Almiron, María Carolina Monti

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Contextual cues linked to drug experience have been frequently associated to craving and relapse, with this phenomenon being described in human and experimental animals. Hippocampal synaptic plasticity has been related to learning, memory, and adapti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa8edb36d5e913aca762f691ce15ce1
https://pubmed.ncbi.nlm.nih.gov/19728364

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