Hydrogen sulfide facilitates reprogramming and trans-differentiation in 3D dermal fibroblast.

Autor: Elena A Ostrakhovitch, Shin Akakura, Siamak Tabibzadeh

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0241685 (2020)

The efficiency of cell reprogramming in two-dimensional (2D) cultures is limited. Given that cellular stemness is intimately related to microenvironmental changes, 3D cell cultures have the potential of overcoming this limited capacity by allowing ce

Externí odkaz: https://doaj.org/article/700966040cc349ce9522a126e840a96f

Contributors

Autor: Jan Aaseth, Peter Aggett, Antero Aitio, Agneta Åkesson, Maria Albin, Jan Alexander, Christian B.I. Andersen, Ole Andersen, Pietro Apostoli, Michael Aschner, Rowa Bakadlag, Lars Barregard, David C. Bellinger, Ingvar A. Bergdahl, Balazs Berlinger, Alfred Bernard, Carolina Bigert, Poul Bjerregaard, Robyn Blain, Lennart K. Blomqvist, Beatrice Bocca, Stephan Bose-O'Reilly, Karin Broberg, Ronald P. Brown, Esben Budtz-Jørgensen, Samuel W. Caito, Tiffany Carle, Chien-Jen Chen, Xiao Chen, Lung-Chi Chen, C.-H. Selene J. Chou, Mitchell D. Cohen, Max Costa, Giuseppe De Palma, Alison Elder, Carl-Gustaf Elinder, Bengt Fadeel, Obaid M. Faroon, Bruce A. Fowler, Hitomi Fujishiro, Silvia Fustinoni, Lars Gerhardsson, Philippe Grandjean, Per Gustavsson, Yolanda Hedberg, Seiichiro Himeno, Xi Huang, Per A. Hultman, Ivo Iavicoli, Taiyi Jin, Robert L. Jones, Hanna L. Karlsson, Larry S. Keith, Yangho Kim, Catherine B. Klein, Michael Kleinman, David Kotelchuck, Yukinori Kusaka, Philip J. Landrigan, Per E. Leffler, Veruscka Leso, Alex Heng Li, Dominique Lison, Shan Liu, Roberto G. Lucchini, Polina Maciejczyk, Koren K. Mann, Nikki Maples-Reynolds, Michael J. Maroney, Airton C. Martins, Mary S. Matsui, Daphne B. Moffett, Lisbeth Birk Møller, M. Moiz Mumtaz, Makiko Nakano, Benoit Nemery, Koji Nogawa, Gunnar F. Nordberg, Monica Nordberg, Angelica Ortiz, Agneta Oskarsson, Elena A. Ostrakhovitch, Cezary M. Pałczyński, Natalia Pawlas, Daniela Pelclova, Maria Pesonen, K. Michael Pollard, Lothar Rink, Flavia Ruggieri, Patricia Ruiz, Harold H. Sandstead, Tiina Santonen, Kazuhiro Sato, Hiroshi Satoh, Deepak Saxena, Greet Schoeters, Bengt Sjögren, Staffan Skerfving, Donald R. Smith, Dexter W. Sullivan, Daigo Sumi, Hong Sun, Hille Suojalehto, Akiyo Tanaka, Milton Tenenbein, George D. Thurston, Francisco A. Tomei Torres, Muhammet S. Toprak, Carolyn A. Tylenda, Julian F. Tyson, Tomohiro Umemura, Margaret H. Whittaker, Jana Wolf, Wenbo Yan, Robert A. Yokel, Rudolfs K. Zalups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5280a02c2c7fb209a75944eb8170f23
https://doi.org/10.1016/b978-0-12-823292-7.01002-0

A H2S-Nampt dependent energetic circuit is critical to survival and cytoprotection from damage in cancer cells.

Autor: Reiko Sanokawa-Akakura, Elena A Ostrakhovitch, Shin Akakura, Scott Goodwin, Siamak Tabibzadeh

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108537 (2014)

We recently demonstrated that cancer cells that recover from damage exhibit increased aerobic glycolysis, however, the molecular mechanism by which cancer cells survive the damage and show increased aerobic glycolysis remains unknown. Here, we demons

Externí odkaz: https://doaj.org/article/83e2b1bcc0bf4af7a62356cf98aec4f6

Hydrogen sulfide facilitates reprogramming and trans-differentiation in 3D dermal fibroblast

Autor: Siamak Tabibzadeh, Elena A. Ostrakhovitch, Shin Akakura

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241685 (2020)

The efficiency of cell reprogramming in two-dimensional (2D) cultures is limited. Given that cellular stemness is intimately related to microenvironmental changes, 3D cell cultures have the potential of overcoming this limited capacity by allowing ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eeaa82ea3d44cbd308881f1f21ee5d8
http://europepmc.org/articles/PMC7660576

Cancer cells recovering from damage exhibit mitochondrial restructuring and increased aerobic glycolysis

Autor: Shin Akakura, Reiko Sanokawa-Akakura, Siamak Tabibzadeh, Elena A. Ostrakhovitch

Publikováno v: Biochemical and Biophysical Research Communications. 448:461-466

Instead of relying on mitochondrial oxidative phosphorylation, most cancer cells rely heavily on aerobic glycolysis, a phenomenon termed as “the Warburg effect”. We considered that this effect is a direct consequence of damage which persists in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cda9bb529bef807203e36b5a9479b3c
https://doi.org/10.1016/j.bbrc.2014.04.138