Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Elena A. Lesnik"'
Autor:
Gary B. Fogel, Rangarajan Sampath, David J. Ecker, Elena A. Lesnik, Dana Weekes, Timothy J. Henderson, Harold B. Levene
Publikováno v:
Biosystems. 80:145-154
A combination of algorithms to search RNA sequence for the potential for secondary structure formation, and search large numbers of sequences for structural similarity, were used to search the 5'UTRs of annotated genes in the Escherichia coli genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3bfd12634931f56a8372af6242a216
https://doi.org/10.1016/j.biosystems.2004.11.002
https://doi.org/10.1016/j.biosystems.2004.11.002
Autor:
Mohan, Tereshko, A. Puschl, Elena A. Lesnik, Martin Egli, Muthiah Manoharan, Thazha P. Prakash
Publikováno v:
Organic Letters. 6:1971-1974
[structure: see text] Oligonucleotides with a novel 2'-O-[2-(guanidinium)ethyl] (2'-O-GE) modification have been synthesized using a novel protecting group strategy for the guanidinium group. This modification enhances the binding affinity of oligonu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0fb4cf153d1e356ad3116f00f0dd82
https://doi.org/10.1021/ol049470e
https://doi.org/10.1021/ol049470e
Publikováno v:
Tetrahedron. 59:7413-7422
Synthesis of a series of 2′-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified 5-methyluridine nucleoside phosphoramidites and solid supports are described. Using these monomers, modified oligonucleotides containing phosphodiester linkages were synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88709640277504db30f5282da5f60bf7
https://doi.org/10.1016/s0040-4020(03)01104-9
https://doi.org/10.1016/s0040-4020(03)01104-9
Publikováno v:
ChemBioChem. 3:1257-1260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136818ae9708d5aabda47c7942b72f8e
https://doi.org/10.1002/1439-7633(20021202)3:12<1257::aid-cbic1257>3.0.co
https://doi.org/10.1002/1439-7633(20021202)3:12<1257::aid-cbic1257>3.0.co
Autor:
David B. Fogel, Rangarajan Sampath, Richard H. Griffey, David J. Ecker, John Mcneil, Elena A. Lesnik, V. William Porto, Gary B. Fogel, Dana Weekes
Publikováno v:
Nucleic Acids Research. 30:5310-5317
RNA molecules fold into characteristic secondary and tertiary structures that account for their diverse functional activities. Many of these RNA structures, or certain structural motifs within them, are thought to recur in multiple genes within a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e786ff3c134d78534b5b3f0e6cf0c1
https://doi.org/10.1093/nar/gkf653
https://doi.org/10.1093/nar/gkf653
Publikováno v:
Organic Letters. 4:4395-4398
[structure: see text] Peptide nucleic acid (PNA) monomers containing the tricyclic cytosine analogues phenoxazine, 9-(2-aminoethoxy)phenoxazine (G-clamp), and 9-(3-aminopropoxy)phenoxazine (propyl-G-clamp) have been synthesized. The modified nucleoba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800ce72ec94e1b685e08929feb46ea90
https://doi.org/10.1021/ol027026a
https://doi.org/10.1021/ol027026a
Autor:
Lawrence B. Blyn, Dave J. Ecker, Elena A. Lesnik, Rangarajan Sampath, Shuo Chen, Thomas A. Hall, Richard H. Griffey
Publikováno v:
Biosystems. 65:157-177
The recent explosion in available bacterial genome sequences has initiated the need to improve an ability to annotate important sequence and structural elements in a fast, efficient and accurate manner. In particular, small non-coding RNAs (sRNAs) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee5730591bb47d8772c76fb1b73f12c
https://doi.org/10.1016/s0303-2647(02)00013-8
https://doi.org/10.1016/s0303-2647(02)00013-8
Publikováno v:
Tetrahedron Letters. 42:8777-8780
In order to evaluate the effect of a new 2′-carbohydrate modification on the hybridization properties of oligonucleotides, uridine 2′- O -carbamates were synthesized and incorporated into DNA strands. The key intermediate in the synthesis, a mixe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8941b260d430644eb82555b6b8eab223
https://doi.org/10.1016/s0040-4039(01)01908-6
https://doi.org/10.1016/s0040-4039(01)01908-6
Autor:
Timothy J. Henderson, John Mcneil, Harold B. Levene, Elena A. Lesnik, David J. Ecker, Rangarajan Sampath
Publikováno v:
Nucleic Acids Research. 29:3583-3594
A new algorithm called RNAMotif containing RNA structure and sequence constraints and a thermodynamic scoring system was used to search for intrinsic rho-independent terminators in the Escherichia coli K-12 genome. We identified all 135 reported term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fb63e97ed763b56508ac62caf44236
https://doi.org/10.1093/nar/29.17.3583
https://doi.org/10.1093/nar/29.17.3583
Autor:
Thazha P. Prakash, Stephen Owens, Andrew M. Kawasaki, Muthiah Manoharan, Elena A. Lesnik, Allister S. Fraser
Publikováno v:
Tetrahedron Letters. 41:4855-4859
A novel 2′-modification, 2′-O-[3-(N,N-dimethylamino)propyl] or 2′-O-DMAP, has been incorporated into oligonucleotides and compared to the known 2′-O-(3-aminopropyl) or 2′-O-AP modification for antisense properties. The 2′-O-DMAP modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa24e5d48914a72c927f765c213d403e
https://doi.org/10.1016/s0040-4039(00)00703-6
https://doi.org/10.1016/s0040-4039(00)00703-6