Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Elena A. Kashentseva"'
Autor:
Kexin Geng, Paul J. Rice-Boucher, Elena A. Kashentseva, Igor P. Dmitriev, Zhi Hong Lu, S. Peter Goedegebuure, William E. Gillanders, David T. Curiel
Publikováno v:
Viruses, Vol 15, Iss 11, p 2277 (2023)
mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for personalization. However, current mRNA vaccine platforms have not been optimized for induction of
Externí odkaz:
https://doaj.org/article/f5cd8059bf8f48c1a2dd7fc84922e25f
Autor:
Rebeca González-Pastor, Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva, Zhi Hong Lu, S. Peter Goedegebuure, Osvaldo L. Podhajcer, David T. Curiel
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds has sought to exploi
Externí odkaz:
https://doaj.org/article/7c2b01e7eb2848b08117b81f96e23ec9
Autor:
Payal Agarwal, Elizabeth A. Gammon, Maninder Sandey, Stephanie S. Lindley, Jey W. Koehler, Brad M. Matz, Annette N. Smith, Elena A. Kashentseva, Igor P. Dmitriev, David T. Curiel, Bruce F. Smith
Publikováno v:
Heliyon, Vol 7, Iss 2, Pp e06210- (2021)
Osteosarcoma is one among the most common neoplasms in dogs. Current treatments show limited efficacy and fail to prevent metastasis. Conditionally replicative adenoviruses (CRAd) replicate exclusively in targeted tumor cells and release new virus pa
Externí odkaz:
https://doaj.org/article/4dbf0481a54a46e8828a185aa8bd55a8
Autor:
Ahmed O. Hassan, Igor P. Dmitriev, Elena A. Kashentseva, Haiyan Zhao, Douglas E. Brough, Daved H. Fremont, David T. Curiel, Michael S. Diamond
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2634-2646.e4 (2019)
Summary: The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) protei
Externí odkaz:
https://doaj.org/article/353b0f2914c9464db388d5b645a448dd
Autor:
Igor P. Dmitriev, Elena A. Kashentseva, Kenneth H. Kim, Qiana L. Matthews, Stephanie S. Krieger, Jesse J. Parry, Kim N. Nguyen, Walter J. Akers, Samuel Achilefu, Buck E. Rogers, Ronald D. Alvarez, David T. Curiel
Publikováno v:
Molecular Imaging, Vol 13 (2014)
A significant limiting factor to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy is the inability to noninvasively monitor these agents and their potential persistence. To address this issue, we propose
Externí odkaz:
https://doaj.org/article/11c8a7d66c1b42468dc6db1106f96ab5
Publikováno v:
ACS Nano. 16:10443-10455
The capacity to efficiently deliver the gene-editing enzyme complex to target cells is favored over other forms of gene delivery as it offers one-time hit-and-run gene editing, thus improving precision and safety and reducing potential immunogenicity
Autor:
Baoling Ying, Tamarand L. Darling, Pritesh Desai, Chieh-Yu Liang, Igor P. Dmitriev, Nadia Soudani, Traci Bricker, Elena A. Kashentseva, Houda Harastani, Aaron G. Schmidt, David T. Curiel, Adrianus C.M. Boon, Michael S. Diamond
Publikováno v:
bioRxiv
We previously described a nasally delivered monovalent adenoviral-vectored SARS- CoV-2 vaccine (ChAd-SARS-CoV-2-S, targeting Wuhan-1 spike [S]; iNCOVACC®) that is currently used in India as a primary or booster immunization. Here, we updated the muc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4feaa7ebcb1e93aae8f29179bab87c2
https://doi.org/10.1101/2023.05.04.539332
https://doi.org/10.1101/2023.05.04.539332
Autor:
Erica Ollmann Saphire, Elena A. Kashentseva, Daved H. Fremont, Saravanan Raju, Matthew J. Gorman, Igor P. Dmitriev, Colin Mann, Rita E. Chen, Ahmed O. Hassan, Meredith E. Davis-Gardner, Michael S. Diamond, Mehul S. Suthar, Swathi Shrihari, Pei Yong Shi, Dansu Yaun, Galit Alter, Baoling Ying, David T. Curiel, Lucas J. Adams
Publikováno v:
Cell Reports
Cell Reports, Vol 36, Iss 4, Pp 109452-(2021)
Cell Reports, Vol 36, Iss 4, Pp 109452-(2021)
Summary SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally administered spike protein-based chimpanzee adenovirus-vectored vaccine (ChAd-SARS-C
Autor:
David T. Curiel, Pei Yong Shi, Daved H. Fremont, Baoling Ying, Igor P. Dmitriev, Galit Alter, Saravanan Raju, Matthew J. Gorman, Rita E. Chen, Elena A. Kashentseva, Swathi Shrihari, Michael S. Diamond, Lucas J. Adams, Ahmed O. Hassan, Dansu Yuan
SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy and the end of the COVID-19 pandemic. We recently reported the protective activity of a single-dose intranasally-administered spike protein-based chimpanzee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb4b626673618967b386300dc331b1a
https://doi.org/10.1101/2021.05.08.443267
https://doi.org/10.1101/2021.05.08.443267
Autor:
Rebeca Gonzalez-Pastor, Igor P. Dmitriev, Charles B. Shoemaker, David T. Curiel, Elena A. Kashentseva, Bradley St. Croix, Myungeun Lee, Zhi Hong Lu, Steven Seaman, Jacqueline M. Tremblay
Publikováno v:
J Control Release
For the developing field of gene therapy the successful address of the basic requirement effective gene delivery has remained a critical barrier. In this regard, the "Holy Grail" vector envisioned by the field's pioneers embodied the ability to achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7bd1354bd0cae24b0a2ae8098fa225
https://europepmc.org/articles/PMC10292108/
https://europepmc.org/articles/PMC10292108/