Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Elena A Govorkova"'
Autor:
Jeremy C Jones, Bogdan Zagribelnyy, Philippe Noriel Q Pascua, Dmitry S Bezrukov, Subrata Barman, Faten Okda, Richard J Webby, Yan A Ivanenkov, Elena A Govorkova
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010698 (2022)
Baloxavir marboxil (BXM) is approved for treating uncomplicated influenza. The active metabolite baloxavir acid (BXA) inhibits cap-dependent endonuclease activity of the influenza virus polymerase acidic protein (PA), which is necessary for viral tra
Externí odkaz:
https://doaj.org/article/2694018c3db045d388d268431eb44993
Autor:
Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L DeDiego, Brian R Wasik, Benjamin L Miller, Carole Henry, Patrick C Wilson, Mark Y Sangster, John J Treanor, David J Topham, Lauren Byrd-Leotis, David A Steinhauer, Richard D Cummings, Jasmina M Luczo, Stephen M Tompkins, Kaori Sakamoto, Cheryl A Jones, John Steel, Anice C Lowen, Shamika Danzy, Hui Tao, Ashley L Fink, Sabra L Klein, Nicholas Wohlgemuth, Katherine J Fenstermacher, Farah El Najjar, Andrew Pekosz, Lauren Sauer, Mitra K Lewis, Kathryn Shaw-Saliba, Richard E Rothman, Zhen-Ying Liu, Kuan-Fu Chen, Colin R Parrish, Ian E H Voorhees, Yoshihiro Kawaoka, Gabriele Neumann, Shiho Chiba, Shufang Fan, Masato Hatta, Huihui Kong, Gongxun Zhong, Guojun Wang, Melissa B Uccellini, Adolfo García-Sastre, Daniel R Perez, Lucas M Ferreri, Sander Herfst, Mathilde Richard, Ron Fouchier, David Burke, David Pattinson, Derek J Smith, Victoria Meliopoulos, Pamela Freiden, Brandi Livingston, Bridgett Sharp, Sean Cherry, Juan Carlos Dib, Guohua Yang, Charles J Russell, Subrata Barman, Richard J Webby, Scott Krauss, Angela Danner, Karlie Woodard, Malik Peiris, R A P M Perera, M C W Chan, Elena A Govorkova, Bindumadhav M Marathe, Philippe N Q Pascua, Gavin Smith, Yao-Tsun Li, Paul G Thomas, Stacey Schultz-Cherry
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008409 (2020)
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) hav
Externí odkaz:
https://doaj.org/article/a276b3ba47c444b9b66890d5fe29aa86
Autor:
Nipaporn Tewawong, Bindumadhav M Marathe, Yong Poovorawan, Sompong Vongpunsawad, Richard J Webby, Elena A Govorkova
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190877 (2018)
Amino acid substitutions within or near the active site of the viral neuraminidase (NA) may affect influenza virus fitness. In influenza A(H3N2) and B viruses circulating in Thailand between 2010 and 2015, we identified several NA substitutions that
Externí odkaz:
https://doaj.org/article/c6ae8faa2daf4d3f80ca54d2c4ac436b
Autor:
Philippe Noriel Q Pascua, Bindumadhav M Marathe, Andrew J Burnham, Peter Vogel, Richard J Webby, Robert G Webster, Elena A Govorkova
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159847 (2016)
Neuraminidase (NA) inhibitors (NAIs) are the only antiviral drugs recommended for influenza treatment and prophylaxis. Although NAI-resistant influenza B viruses that could pose a threat to public health have been reported in the field, their fitness
Externí odkaz:
https://doaj.org/article/deb22f1b419f4178b3f8b25e50e8a9a9
Autor:
Rabeh El-Shesheny, John Franks, Ahmed Kandeil, Rebecca Badra, Jasmine Turner, Patrick Seiler, Bindumadhav M. Marathe, Trushar Jeevan, Lisa Kercher, Meng Hu, Yul Eum Sim, Kenrie P. Y. Hui, Michael C. W. Chan, Andrew J. Thompson, Pamela McKenzie, Elena A. Govorkova, Charles J. Russell, Peter Vogel, James C. Paulson, J. S. Malik Peiris, Robert G. Webster, Mohamed A. Ali, Ghazi Kayali, Richard J. Webby
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To
Externí odkaz:
https://doaj.org/article/0e383400a9d3481ebc14bb85730eae93
Autor:
Allison Murawski, Thomas Fabrizio, Robert Ossiboff, Christina Kackos, Trushar Jeevan, Jeremy C. Jones, Ahmed Kandeil, David Walker, Jasmine C. M. Turner, Christopher Patton, Elena A. Govorkova, Helena Hauck, Suzanna Mickey, Brittany Barbeau, Y. Reddy Bommineni, Mia Torchetti, Kristina Lantz, Lisa Kercher, Andrew B. Allison, Peter Vogel, Michael Walsh, Richard J. Webby
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in bird
Externí odkaz:
https://doaj.org/article/f077851e17244c52914bd58d8ee3025c
Autor:
Micaela B Reddy, Kuo-Hsiung Yang, Gauri Rao, Craig R Rayner, Jing Nie, Chandrasena Pamulapati, Bindumadhav M Marathe, Alan Forrest, Elena A Govorkova
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138069 (2015)
The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret
Externí odkaz:
https://doaj.org/article/a49aee039bfc48029ef118ebff789af5
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71401 (2013)
The influenza neuraminidase (NA) enzyme cleaves terminal sialic acid residues from cellular receptors, a process required for the release of newly synthesized virions. A balance of NA activity with sialic acid binding affinity of hemagglutinin (HA) i
Externí odkaz:
https://doaj.org/article/8fe59209ff6c4f4aa2cc0c8acdd7b0f6
Autor:
Ghazi Kayali, Richard J Webby, Mariette F Ducatez, Rabeh A El Shesheny, Ahmed M Kandeil, Elena A Govorkova, Ahmed Mostafa, Mohamed A Ali
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17730 (2011)
With 119 confirmed cases between March 2006 and December 2010, Egypt ranks second among countries reporting human H5N1 influenza virus infections. In 2009-2010, Egypt reported 68 new human cases and became the new epicenter for H5N1 infections. We co
Externí odkaz:
https://doaj.org/article/4c5f937429e14327837c6d612dbb4cf0
Autor:
Susu Duan, David A Boltz, Patrick Seiler, Jiang Li, Karoline Bragstad, Lars P Nielsen, Richard J Webby, Robert G Webster, Elena A Govorkova
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1001022 (2010)
The neuraminidase (NA) inhibitor oseltamivir offers an important immediate option for the control of influenza, and its clinical use has increased substantially during the recent H1N1 pandemic. In view of the high prevalence of oseltamivir-resistant
Externí odkaz:
https://doaj.org/article/90187fd9b20c424680d55fb6d2ae5021