Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Elena A, Gracheva"'
Autor:
Sarah M. Mohr, Rafael Dai Pra, Maryann P. Platt, Viktor V. Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K. Merriman, Tamas L. Horvath, Sviatoslav N. Bagriantsev, Elena O. Gracheva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-
Externí odkaz:
https://doaj.org/article/85482d9133b24981b7be3db42e371392
Autor:
Arthur Neuberger, Mai Oda, Yury A. Nikolaev, Kirill D. Nadezhdin, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted the dangers of treating pain with opioids. An alternative addiction-free strategy to conventional painkiller-based treatment is targeting receptors at
Externí odkaz:
https://doaj.org/article/877e76e36dfb4876a5ee47fd8b5baa33
Publikováno v:
eLife, Vol 12 (2023)
Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers). While the afferent terminal is generally understood to be the primary site of mecha
Externí odkaz:
https://doaj.org/article/633763f3bf094e46af7079f3d100c1cc
Autor:
Kirill D. Nadezhdin, Arthur Neuberger, Yury A. Nikolaev, Lyle A. Murphy, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV
Externí odkaz:
https://doaj.org/article/c4fde09e03ba45fbaf81d692cd390f1c
Autor:
Anna A. Mukhina, Natalya B. Kuzmenko, Yulia A. Rodina, Irina V. Kondratenko, Andrei A. Bologov, Tatiana V. Latysheva, Andrei P. Prodeus, Alexander N. Pampura, Dmitrii N. Balashov, Natalya I. Ilyina, Elena A. Latysheva, Ekaterina A. Deordieva, Oksana A. Shvets, Elena V. Deripapa, Irina N. Abramova, Olga E. Pashenko, Svetlana S. Vahlyarskaya, Natalya V. Zinovyeva, Sergei B. Zimin, Elena V. Skorobogatova, Elena B. Machneva, Daria S. Fomina, Maria G. Ipatova, Ludmila Yu. Barycheva, Ludmila S. Khachirova, Irina A. Tuzankina, Michail A. Bolkov, Natalya V. Shakhova, Elena M. Kamaltynova, Farida I. Sibgatullina, Marina N. Guseva, Raisa N. Kuznetsova, Anzhelika M. Milichkina, Areg A. Totolian, Natalia M. Kalinina, Evgenia A. Goltsman, Ekatherina I. Sulima, Anastasia Yu. Kutlyanceva, Anna A. Moiseeva, Anna L. Khoreva, Zoya Nesterenko, Elena V. Tymofeeva, A. Ermakova, Dilyara D. Proligina, Linara R. Kalmetieva, Gulshat A. Davletbaieva, Irina A. Mirsayapova, Olga A. Richkova, Ksenia P. Kuzmicheva, Maria A. Grakhova, Natalya B. Yudina, Ekaterina A. Orlova, Olga S. Selezneva, Svetlana G. Piskunova, Tatiana V. Samofalova, Tatiana V. Bukina, Anna D. Pechkurova, N. Migacheva, A. Zhestkov, Elena V. Barmina, Natalya A. Parfenova, Svetlana N. Isakova, Elena V. Averina, Irina V. Sazonova, Svetlana Yu. Starikova, Tatiana V. Shilova, Tatiana V. Asekretova, Roman N. Suprun, Elena I. Kleshchenko, Vladimir V. Lebedev, Elena V. Demikhova, Valerii G. Demikhov, Veronica A. Kalinkina, Alla V. Gorenkova, Svetlana N. Duryagina, Tatiana B. Pavlova, Vera M. Shinkareva, Irina V. Smoleva, Tatiana P. Aleksandrova, Zema V. Bambaeva, Marina A. Philippova, Elena M. Gracheva, Galina I. Tcyvkina, Alexey V. Efremenkov, D. Mashkovskaya, Irina V. Yarovaya, Valentina A. Alekseenko, Ivan V. Fisyun, Galina V. Molokova, Ekatherina V. Troitskya, Ludmila I. Piatkina, Elena V. Vlasova, O. Ukhanova, Ekaterina G. Chernishova, M. Vasilieva, Olga M. Laba, E. Volodina, Ekaterina V. Safonova, Kirill A. Voronin, Maria V. Gurkina, Alexander G. Rumyantsev, Galina A. Novichkova, Anna Yu. Shcherbina
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Introduction: Primary immunodeficiencies (PID) are a group of rare genetic disorders with a multitude of clinical symptoms. Characterization of epidemiological and clinical data via national registries has proven to be a valuable tool of studying the
Externí odkaz:
https://doaj.org/article/6acca441337f4d1798744e22d3851bfe
Autor:
Viktor V Feketa, Yury A Nikolaev, Dana K Merriman, Sviatoslav N Bagriantsev, Elena O Gracheva
Publikováno v:
eLife, Vol 9 (2020)
Most mammals maintain their body temperature around 37°C, whereas in hibernators it can approach 0°C without triggering a thermogenic response. The remarkable plasticity of the thermoregulatory system allowed mammals to thrive in variable environme
Externí odkaz:
https://doaj.org/article/595385e2045f4abfbdcfad386e5d816b
Autor:
Evan O. Anderson, Eve R. Schneider, Jon D. Matson, Elena O. Gracheva, Sviatoslav N. Bagriantsev
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 701-708 (2018)
Summary: Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways regulating their activity remain poorly understood. TMEM150C was proposed to mediate mechano-activated current in proprioceptive neurons. Here, we studied functi
Externí odkaz:
https://doaj.org/article/a5d61077223b4d5b9d0aa66788b03bf9
Autor:
Vanessa Matos-Cruz, Eve R. Schneider, Marco Mastrotto, Dana K. Merriman, Sviatoslav N. Bagriantsev, Elena O. Gracheva
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3329-3337 (2017)
Summary: Thirteen-lined ground squirrels and Syrian hamsters are known for their ability to withstand cold during hibernation. We found that hibernators exhibit cold tolerance even in the active state. Imaging and electrophysiology of squirrel somato
Externí odkaz:
https://doaj.org/article/bb9b490c24ae4fc4a0ec9c7cdb8c28a6
Autor:
Eve R. Schneider, Evan O. Anderson, Viktor V. Feketa, Marco Mastrotto, Yury A. Nikolaev, Elena O. Gracheva, Sviatoslav N. Bagriantsev
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 1979-1987.e3 (2019)
Summary: A major challenge in biology is to link cellular and molecular variations with behavioral phenotypes. Here, we studied somatosensory neurons from a panel of bird species from the family Anatidae, known for their tactile-based foraging behavi
Externí odkaz:
https://doaj.org/article/03a6f07b106347a4ba51c0aa226a207f
Publikováno v:
eLife, Vol 8 (2019)
Piezo1 and Piezo2 belong to a family of mechanically-activated ion channels implicated in a wide range of physiological processes. Mechanical stimulation triggers Piezo channels to open, but their characteristic fast inactivation process results in r
Externí odkaz:
https://doaj.org/article/8f5dda3774ad4221a4a37d7e483abf34