Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elena, de Blas"'
Autor:
María Cristina Estañ, Eva Calviño, Susana Calvo, Beatriz Guillén-Guío, María Del Carmen Boyano-Adánez, Elena de Blas, Eduardo Rial, Patricio Aller
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115250 (2014)
Fatty acid synthesis and oxidation are frequently exacerbated in leukemia cells, and may therefore represent a target for therapeutic intervention. In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty acid oxidation inhibi
Externí odkaz:
https://doaj.org/article/a6bc04a63931480abbef0c624acfdc1e
Autor:
Patricio Aller, Carlos Sanchez-Martin, Eva Calviño, María Cristina Estañ, Eduardo Rial, Rocío Brea, María del Carmen Boyano-Adánez, Elena de Blas
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:324-335
3-Bromopyruvate (3-BrP) is an alkylating, energy-depleting drug that is of interest in antitumor therapies, although the mechanisms underlying its cytotoxicity are ill-defined. We show here that 3-BrP causes concentration-dependent cell death of HL60
Autor:
María del Carmen Boyano-Adánez, Javier Ramos, Elena de Blas, Patricio Aller, María Cristina Estañ, María del Carmen Gómez de Frutos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancer Cell International
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
instname
Cancer Cell International
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
16 p.-8 fig.
Background: The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and MEK/ERK d
Background: The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and MEK/ERK d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c259ce22719ddb70b25eb92e7d65d9
http://hdl.handle.net/10261/137143
http://hdl.handle.net/10261/137143
Publikováno v:
Biochemical Pharmacology. 77:384-396
While it has been reported that genistein induces differentiation in multiple tumour cell models, the signalling and regulation of isoflavone-provoked differentiation are poorly known. We here demonstrate that genistein causes G(2)/M cycle arrest and
Autor:
Consuelo Calle, Yolanda Sánchez, Patricio Aller, Carlos Fernández, Elena de Blas, Jacqueline Bréard, Donna Amrán, Adrian M. Ramos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
11 páginas, 7 figuras -- PAGS nros. 1653-1663
Treatment with the anti-leukemic drug arsenic trioxide (As2O3, 1–4 μM) sensitizes U937 promonocytes and other human myeloid leukemia cell lines (HL60, NB4) to apoptosis induction by TNFα. As2O3
Treatment with the anti-leukemic drug arsenic trioxide (As2O3, 1–4 μM) sensitizes U937 promonocytes and other human myeloid leukemia cell lines (HL60, NB4) to apoptosis induction by TNFα. As2O3
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
7 páginas, 5 figuras, 1 tabla -- PAGS nros. 104-110
In an attempt to design new antitumoral drugs based on transplatin complexes, we determined the experimental conditions for the preparation of trans-[Pt((CH3)2CNOH)((CH3)2CHNH2)Cl2], and solve
In an attempt to design new antitumoral drugs based on transplatin complexes, we determined the experimental conditions for the preparation of trans-[Pt((CH3)2CNOH)((CH3)2CHNH2)Cl2], and solve
Autor:
Patricio Aller, Carlos Fernández, Patricia Sancho, Elena de Blas, Adrian M. Ramos, Donna Amrán
Publikováno v:
Journal of Biological Chemistry. 279:3877-3884
Arsenic trioxide (As2O3) caused apoptosis in U-937 human promonocytic cells. This effect was potentiated by the simultaneous addition of the glutathione (GSH) synthesis inhibitor dl-buthionine-(R,S)-sulfoximine or the protein kinase C activators 12-O
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
9 páginas, 6 figuras -- PAGS nros. 581-589
The administration of the H2O2-specific scavenger catalase attenuated the generation of apoptosis by the antitumor drugs etoposide, camptothecin, doxorubicin, and cisplatin in U-937 human promonocytic
The administration of the H2O2-specific scavenger catalase attenuated the generation of apoptosis by the antitumor drugs etoposide, camptothecin, doxorubicin, and cisplatin in U-937 human promonocytic
Autor:
Eduardo Rial, Patricio Aller, María del Carmen Boyano-Adánez, Elena de Blas, Susana Calvo, Eva Calviño, Beatriz Guillén-Guío, María Cristina Estañ
Publikováno v:
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 9, Iss 12, p e115250 (2014)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 9, Iss 12, p e115250 (2014)
26 p.-9 fig.
Fatty acid synthesis and oxidation are frequently exacerbated in leukemia cells, and may therefore represent a target for therapeutic intervention. In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty aci
Fatty acid synthesis and oxidation are frequently exacerbated in leukemia cells, and may therefore represent a target for therapeutic intervention. In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty aci
Publikováno v:
Journal of Biological Chemistry. 276:47107-47115
Treatment with the DNA topoisomerase inhibitors etoposide, doxorubicin, and camptothecin, and with the alkylating agents cisplatin and melphalan, caused peroxide accumulation and apoptosis in U-937 human promonocytic cells. Preincubation with the red