Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Elena, Sperk"'
Autor:
Frank A. Giordano, Julian P. Layer, Sonia Leonardelli, Lea L. Friker, Roberta Turiello, Dillon Corvino, Thomas Zeyen, Christina Schaub, Wolf Müller, Elena Sperk, Leonard Christopher Schmeel, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Torsten Pietsch, Sotirios Bisdas, Michael Platten, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT) by facilitating vasculogenesis. Here we report outcomes of the dose-escalation part of GLORIA (NCT04121455), a phase I/II trial combining RT and the CXCL12-n
Externí odkaz:
https://doaj.org/article/a461b70c215e421cabb2b9a14f5dfb4b
Autor:
Tanwiwat Jaikuna, Fiona Wilson, David Azria, Jenny Chang-Claude, Maria Carmen De Santis, Sara Gutiérrez-Enríquez, Marcel van Herk, Peter Hoskin, Lea Kotzki, Maarten Lambrecht, Zoe Lingard, Petra Seibold, Alejandro Seoane, Elena Sperk, R Paul Symonds, Christopher J. Talbot, Tiziana Rancati, Tim Rattay, Victoria Reyes, Barry S. Rosenstein, Dirk de Ruysscher, Ana Vega, Liv Veldeman, Adam Webb, Catharine ML West, Marianne C Aznar, Eliana Vasquez Osorio
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 32, Iss , Pp 100635- (2024)
Background and purpose: Image-based data mining (IBDM) requires spatial normalisation to reference anatomy, which is challenging in breast radiotherapy due to variations in the treatment position, breast shape and volume. We aim to optimise spatial n
Externí odkaz:
https://doaj.org/article/9b272ec98e184d2cb5dfb2efe4cc8e0a
Autor:
Katharina Sahm, Tobias Kessler, Philipp Eisele, Miriam Ratliff, Elena Sperk, Laila König, Michael O. Breckwoldt, Corinna Seliger, Iris Mildenberger, Daniel Schrimpf, Christel Herold-Mende, Pia S. Zeiner, Ghazaleh Tabatabai, Sven G. Meuth, David Capper, Martin Bendszus, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-9 (2023)
Abstract Background Concurrent malignant brain tumors in patients with multiple sclerosis (MS) constitute a rare but paradigmatic phenomenon for studying neuroimmunological mechanisms from both molecular and clinical perspectives. Methods A multicent
Externí odkaz:
https://doaj.org/article/85b83cf8178849efa2c0227482eb36de
Autor:
Tanwiwat Jaikuna, Eliana Vasquez Osorio, David Azria, Jenny Chang-Claude, Maria Carmen De Santis, Sara Gutiérrez-Enríquez, Marcel van Herk, Peter Hoskin, Maarten Lambrecht, Zoe Lingard, Petra Seibold, Alejandro Seoane, Elena Sperk, R Paul Symonds, Christopher J. Talbot, Tiziana Rancati, Tim Rattay, Victoria Reyes, Barry S. Rosenstein, Dirk de Ruysscher, Ana Vega, Liv Veldeman, Adam Webb, Catharine M.L. West, Marianne C. Aznar
Publikováno v:
Breast, Vol 72, Iss , Pp 103578- (2023)
Background: Normal tissue complication probability (NTCP) models can be useful to estimate the risk of fibrosis after breast-conserving surgery (BCS) and radiotherapy (RT) to the breast. However, they are subject to uncertainties. We present the impa
Externí odkaz:
https://doaj.org/article/e25f42a696f54fbd825c0277b21e99f4
Autor:
Qingyu Xu, Alexander Streuer, Johann-Christoph Jann, Eva Altrock, Nanni Schmitt, Johanna Flach, Carla Sens-Albert, Felicitas Rapp, Julia Wolf, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Mariia Kuzina, Ahmed Jawhar, Ali Darwich, Cleo-Aron Weis, Alexander Marx, Patrick Wuchter, Victor Costina, Evelyn Jäger, Elena Sperk, Michael Neumaier, Alice Fabarius, Georgia Metzgeroth, Florian Nolte, Laurenz Steiner, Pavel A. Levkin, Mohamad Jawhar, Wolf-Karsten Hofmann, Vladimir Riabov, Daniel Nowak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Hypomethylating agents, such as 5-Azacytidine (5-AZA), are standard of care for patients with myelodysplastic and myeloid malignancies, however response rates are limited and risk of relapses high. Here the authors show that inhibition of lysyl oxida
Externí odkaz:
https://doaj.org/article/91b523f59ac547d99572fb13b46e1d2f
Autor:
Adam J. Webb, Emily Harper, Tim Rattay, Miguel E. Aguado-Barrera, David Azria, Celine Bourgier, Muriel Brengues, Erik Briers, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Alessandro Cicchetti, Dirk De Ruysscher, Maria Carmen De Santis, Alison M. Dunning, Rebecca M. Elliott, Laura Fachal, Antonio Gómez-Caamaño, Sara Gutiérrez-Enríquez, Kerstie Johnson, Ramón Lobato-Busto, Sarah L. Kerns, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Petra Seibold, Alejandro Seoane, Paloma Sosa-Fajardo, Elena Sperk, Begoña Taboada-Valladares, Riccardo Valdagni, Ana Vega, Liv Veldeman, Tim Ward, Catharine M. West, R. Paul Symonds, Christopher J. Talbot
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104269- (2022)
Summary: Background: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time analyses and ta
Externí odkaz:
https://doaj.org/article/097e7e00ef4744c287a2116c62e23053
Autor:
Nuradh Joseph, Alessandro Cicchetti, Alan McWilliam, Adam Webb, Petra Seibold, Claudio Fiorino, Cesare Cozzarini, Liv Veldeman, Renée Bultijnck, Valérie Fonteyne, Christopher J. Talbot, Paul R. Symonds, Kerstie Johnson, Tim Rattay, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, David Azria, Marie-Pierre Farcy Jacquet, Marie Charissoux, Ana Vega, Miguel E. Aguado-Barrera, Antonio Gómez-Caamaño, Pierfrancesco Franco, Elisabetta Garibaldi, Giuseppe Girelli, Cinzia Iotti, Vittotorio Vavassori, Jenny Chang-Claude, Catharine M. L. West, Tiziana Rancati, Ananya Choudhury
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionWe hypothesized that increasing the pelvic integral dose (ID) and a higher dose per fraction correlate with worsening fatigue and functional outcomes in localized prostate cancer (PCa) patients treated with external beam radiotherapy (EBR
Externí odkaz:
https://doaj.org/article/f2bb34992a8046558fc9d3a6f82986a3
Autor:
Mahmoud Aldraimli, PhD, Sarah Osman, PhD, Diana Grishchuck, MSc, Samuel Ingram, MSc, Robert Lyon, PhD, Anil Mistry, MSc, Jorge Oliveira, PhD, Robert Samuel, MBChB, Leila E.A. Shelley, PhD, Daniele Soria, PhD, Miriam V. Dwek, PhD, Miguel E. Aguado-Barrera, MD, PhD, David Azria, MD, Jenny Chang-Claude, PhD, Alison Dunning, PhD, Alexandra Giraldo, MD, Sheryl Green, MD, Sara Gutiérrez-Enríquez, PhD, Carsten Herskind, PhD, Hans van Hulle, MD, Maarten Lambrecht, MD, Laura Lozza, MD, Tiziana Rancati, MSc, Victoria Reyes, MD, Barry S. Rosenstein, PhD, Dirk de Ruysscher, MD, Maria C. de Santis, MD, Petra Seibold, PhD, Elena Sperk, MD, R. Paul Symonds, MD, Hilary Stobart, Begoña Taboada-Valadares, MD, Christopher J. Talbot, PhD, Vincent J.L. Vakaet, MD, Ana Vega, PhD, Liv Veldeman, MD, PhD, Marlon R. Veldwijk, PhD, Adam Webb, PhD, Caroline Weltens, MD, Catharine M. West, PhD, Thierry J. Chaussalet, PhD, Tim Rattay, MBChB, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 3, Pp 100890- (2022)
Purpose: Some patients with breast cancer treated by surgery and radiation therapy experience clinically significant toxicity, which may adversely affect cosmesis and quality of life. There is a paucity of validated clinical prediction models for rad
Externí odkaz:
https://doaj.org/article/496ce594114c42489a36163f25aae676
Autor:
Gustavo R. Sarria, Vera Petrova, Frederik Wenz, Yasser Abo-Madyan, Elena Sperk, Frank A. Giordano
Publikováno v:
Radiation Oncology, Vol 15, Iss 1, Pp 1-7 (2020)
Abstract Background Soft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-energy photons is herei
Externí odkaz:
https://doaj.org/article/f9ebb84c2e6943cd9982da5e4d5a79c4
Autor:
Gustavo R. Sarria, Maria L. Ramos, Amalia Palacios, Ruben Del Castillo, Felipe Castro, Angel Calvo, Jose M. Cotrina, Adela Heredia, Jose A. Galarreta, Paola Fuentes-Rivera, Alicia Avalos, David A. Martinez, Kevin Colqui, Gonzalo Ziegler, Leonard Christopher Schmeel, Luis V. Pinillos, Frederik Wenz, Frank A. Giordano, Gustavo J. Sarria, Elena Sperk
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
PurposeThe purpose of this study was to assess the effectivity of upfront kilovoltage intraoperative radiotherapy (IORT) as a boost in high-risk early-stage breast cancer patients from an international pooled cohort.Materials/MethodsPatients from fou
Externí odkaz:
https://doaj.org/article/a7940da4c27b46a8a21690baa7e052fc