Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Elena, Shanina"'
1
Akademický článek
Targeting undruggable carbohydrate recognition sites through focused fragment library design
Autor: Elena Shanina, Sakonwan Kuhaudomlarp, Eike Siebs, Felix F. Fuchsberger, Maxime Denis, Priscila da Silva Figueiredo Celestino Gomes, Mads H. Clausen, Peter H. Seeberger, Didier Rognan, Alexander Titz, Anne Imberty, Christoph Rademacher
Publikováno v: Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
Carbohydrate–protein interactions are key for cell–cell and host–pathogen recognition, but their hydrophilic nature makes the development of drug-like inhibitors a challenge. Here, screening of fragment libraries identifies metal-binding pharma
Externí odkaz: https://doaj.org/article/4b306191f31141ed861dba296acb045e
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2
Akademický článek
Case Report: Amphiphysin Antibody-Associated Stiff-Limb Syndrome and Myelopathy: An Unusual Presentation of Breast Cancer in an Elderly Woman
Autor: Bhanu Gogia, Elena Shanina, Xiang Fang, Jing He, Xiangping Li
Publikováno v: Frontiers in Neurology, Vol 12 (2021)
Background: Paraneoplastic stiff-limb syndrome (SLS) is a rare manifestation of underlying malignancy and could have distinctive features different from the classic stiff-person syndrome (SPS).Case Description: We present a case of anti-amphiphysin a
Externí odkaz: https://doaj.org/article/393e91ada6e7414eadbfac87be1b7e74
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5
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa
Autor: Hengxi Zhang, Alexander Titz, Christoph Rademacher, Ines Joachim, Eike Siebs, Daniel Varón Silva, Elena Shanina
Publikováno v: Glycobiology
England
The carbohydrate-binding protein LecA (PA-IL) from Pseudomonas aeruginosa plays an important role in the formation of biofilms in chronic infections. Development of inhibitors to disrupt LecA-mediated biofilms is desired but it is limited to carbohyd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635b1103e78462971e8d24abaad82fd7
https://doi.org/10.1093/glycob/cwaa057
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7
Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA
Autor: Peter H. Seeberger, Elena Shanina, Cloé Fortin, Sakonwan Kuhaudomlarp, Didier Rognan, Priscila da Silva Figueiredo Celestino Gomes, Eike Siebs, Anne Imberty, Alexander Titz, Christoph Rademacher
Publikováno v: Chembiochem
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2021, ⟨10.1002/cbic.202100563⟩
International audience; Pseudomonas aeruginosa is an opportunistic ESKAPE pathogen that produces two lectins, LecA and LecB, as part of its large arsenal of virulence factors. Both carbohydrate-binding proteins are central to the initial and later pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e99631bfc55fc32ae354eb640d8058
https://pubmed.ncbi.nlm.nih.gov/34788491
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8
Case Report: Amphiphysin Antibody-Associated Stiff-Limb Syndrome and Myelopathy: An Unusual Presentation of Breast Cancer in an Elderly Woman
Autor: Elena Shanina, Bhanu Gogia, Xiang Fang, Xiangping Li, Jing He
Publikováno v: Frontiers in Neurology, Vol 12 (2021)
Frontiers in Neurology
Background: Paraneoplastic stiff-limb syndrome (SLS) is a rare manifestation of underlying malignancy and could have distinctive features different from the classic stiff-person syndrome (SPS).Case Description: We present a case of anti-amphiphysin a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07838142583393e970def8269773883c
https://www.frontiersin.org/articles/10.3389/fneur.2021.735895/full
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9
Non‐Carbohydrate Glycomimetics as Inhibitors of Calcium(II)‐Binding Lectins
Autor: Annabelle Varrot, Priscila da Silva Figueiredo Celestino Gomes, Anne Imberty, Sakonwan Kuhaudomlarp, Jérémie Topin, Eike Siebs, Christoph Rademacher, Elena Shanina, Ines Joachim, Didier Rognan, Alexander Titz
Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, 60 (15), pp.8104-8114. ⟨10.1002/anie.202013217⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, ⟨10.1002/anie.202013217⟩
Angewandte Chemie
Angewandte Chemie (International ed. in English)
Germany
Angewandte Chemie (International Ed. in English)
Because of the antimicrobial resistance crisis, lectins are considered novel drug targets. Pseudomonas aeruginosa utilizes LecA and LecB in the infection process. Inhibition of both lectins with carbohydrate‐derived molecules can reduce biofilm for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a834ee46ba3ed3629e37b15a6c56dc8
https://hal.archives-ouvertes.fr/hal-03266505
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10
Gabapentin-Induced Myokymia: A Case Report
Autor: Aimalohi Esechie, Elena Shanina, Bhanu Gogia, Alexander Brown
Publikováno v: Clinical neuropharmacology. 44(2)
Background Gabapentin is a commonly used medication for neuropathic pain and epilepsy that is prescribed by a wide range of medical specialties. Adverse effects including asterixis and myoclonus have been described in patients with chronic kidney dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae4a0e4a447c2ac23fd93362b019c8e
https://pubmed.ncbi.nlm.nih.gov/33480615
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