Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elena, Segala"'
Autor:
David Jonathan Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wei Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew Flick, Chulho Choi, Gary Chinigo, James J. Mousseau, John I. Trujillo, Philippe Nuhant, Prolay Mondal, Vincent Lombardo, Daniel Lamb, Barbara J. Hogan, Gurdeep Singh Minhas, Elena Segala, Christine Oswald, Ian W. Windsor, Seungil Han, Mathieu Rappas, Robert M. Cooke, Matthew F. Calabrese, Gabriel Berstein, Atli Thorarensen, Huixian Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The CC chemokine receptor 6 (CCR6) is a potential target for chronic inflammatory diseases. Previously, we reported an active CCR6 structure in complex with its cognate chemokine CCL20, revealing the molecular basis of CCR6 activation. Here,
Externí odkaz:
https://doaj.org/article/91af6bd491994266b492f68b0994ea6e
Autor:
Luca Marcolungo, Alessandro Passera, Simone Maestri, Elena Segala, Massimiliano Alfano, Francesca Gaffuri, Giovanni Marturano, Paola Casati, Piero Attilio Bianco, Massimo Delledonne
Publikováno v:
Pathogens, Vol 11, Iss 2, p 199 (2022)
Rapid and sensitive assays for the identification of plant pathogens are necessary for the effective management of crop diseases. The main limitation of current diagnostic testing is the inability to combine broad and sensitive pathogen detection wit
Externí odkaz:
https://doaj.org/article/0154f933607341b1b1514b24f2e4b5ed
Autor:
Tasia, Amelia, Jacobus P D, van Veldhoven, Matteo, Falsini, Rongfang, Liu, Laura H, Heitman, Gerard J P, van Westen, Elena, Segala, Grégory, Verdon, Robert K Y, Cheng, Robert M, Cooke, Daan, van der Es, Adriaan P, IJzerman
Publikováno v:
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Autor:
Tasia Amelia, Robert K. Y. Cheng, Gerard J. P. van Westen, Rongfang Liu, Elena Segala, Robert M. Cooke, Laura H. Heitman, Jacobus P. D. van Veldhoven, Daan van der Es, Matteo Falsini, Grégory Verdon, Adriaan P. IJzerman
Publikováno v:
Journal of Medicinal Chemistry, 64(7), 3827-3842. American Chemical Society (ACS)
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eaee9ee24339f7b4772a78e3323223
http://hdl.handle.net/1887/3204468
http://hdl.handle.net/1887/3204468
Autor:
Emanuela Cosentino, Elena Pomari, Marzia Rossato, Cristina Beltrami, Elena Segala, Salvatore Scarso, Chiara Degli Esposti, Valentina Grosso, Michela Deiana, Zeno Bisoffi, Chiara Piubelli, Barbara Iadarola, Antonio Mori, Martina Gallinaro, Barbara Giovannone, Luca Marcolungo, Simone Maestri, Denise Lavezzari, Giulia Lopatriello, Marta Paterno, Massimo Delledonne
Publikováno v:
Genomics
Sequencing the SARS-CoV-2 genome from clinical samples can be challenging, especially in specimens with low viral titer. Here we report Accurate SARS-CoV-2 genome Reconstruction (ACoRE), an amplicon-based viral genome sequencing workflow for the comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de40a838694e4190012e998e0dfc4c2f
https://doi.org/10.1101/2021.01.22.21250285
https://doi.org/10.1101/2021.01.22.21250285
Autor:
Andrew S. Doré, James C. Errey, Laura H. Heitman, Adriaan P. IJzerman, Fiona H. Marshall, Elena Segala, Francesca Deflorian, Robert M. Cooke, Dong Guo, Robert K. Y. Cheng, Andrea Bortolato
Publikováno v:
Journal of Medicinal Chemistry, 59(13), 6470-6479
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge StrengthElena Segala, Dong Guo, Robert K. Y. Cheng, Andrea Bortolato, Francesca Deflorian, Andrew S. Doré, James C. Errey, Laura H. Heitman, Ad
Autor:
Fiona H. Marshall, A.S. Dore, Giles A. Brown, Elena Segala, T. Geng, James C. Errey, Robert K. Y. Cheng, Prakash Rucktooa, Robert M. Cooke
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Here we report an efficient method to generate multiple co-structures of the A2A G protein-coupled receptor (GPCR) with small-molecules from a single preparation of a thermostabilised receptor crystallised in Lipidic Cubic Phase (LCP). Receptor cryst
Autor:
Prakash, Rucktooa, Robert K Y, Cheng, Elena, Segala, Tian, Geng, James C, Errey, Giles A, Brown, Robert M, Cooke, Fiona H, Marshall, Andrew S, Doré
Publikováno v:
Scientific Reports
Here we report an efficient method to generate multiple co-structures of the A2A G protein-coupled receptor (GPCR) with small-molecules from a single preparation of a thermostabilised receptor crystallised in Lipidic Cubic Phase (LCP). Receptor cryst
Publikováno v:
FEBS Letters. 589:1399-1405
The options for investigating solubilised G protein-coupled receptors (GPCRs) by biophysical techniques have long been hampered by their instability. A thermostabilised adenosine A2A receptor expressed in insect cells, purified in detergent and recon
Autor:
Daria B. Kokh, Leigh A. Stoddart, Robert M. Cooke, Dorothee Andres, Rebecca C. Wade, Gerhard F. Ecker, Steve Hill, Wilhelmus E. A. de Witte, Marta Amaral, Elena Segala, Bernhard Knasmueller, Matthias Frech, Reggie Bosma, Laura H. Heitman, S. Kashif Sadiq, Anke Muller-Fahrnow, Chris de Graaf, Indira Nederpelt, Dong Guo, Adriaan P. IJzerman, Victoria Georgi, Elizabeth C. M. de Lange, Yin Cheong Wong, Lars Richter, Doris A. Schuetz, Rob Leurs
Publikováno v:
Drug Discovery Today, 22(6), 896-911
Schuetz, D A, de Witte, W E A, Wong, Y C, Knasmueller, B, Richter, L, Kokh, D B, Sadiq, S K, Bosma, R, Nederpelt, I, Heitman, L H, Segala, E, Amaral, M, Guo, D, Andres, D, Georgi, V, Stoddart, L A, Hill, S, Cooke, R M, de Graaf, C, Leurs, R, Frech, M, Wade, R C, de Lange, E C M, IJzerman, A P, Müller-Fahrnow, A & Ecker, G F 2017, ' Kinetics for Drug Discovery : an industry-driven effort to target drug residence time ', Drug Discovery Today, vol. 22, no. 6, pp. 896-911 . https://doi.org/10.1016/j.drudis.2017.02.002
Drug Discovery Today
Schuetz, D A, de Witte, W E A, Wong, Y C, Knasmueller, B, Richter, L, Kokh, D B, Sadiq, S K, Bosma, R, Nederpelt, I, Heitman, L H, Segala, E, Amaral, M, Guo, D, Andres, D, Georgi, V, Stoddart, L A, Hill, S, Cooke, R M, de Graaf, C, Leurs, R, Frech, M, Wade, R C, de Lange, E C M, IJzerman, A P, Müller-Fahrnow, A & Ecker, G F 2017, ' Kinetics for Drug Discovery : an industry-driven effort to target drug residence time ', Drug Discovery Today, vol. 22, no. 6, pp. 896-911 . https://doi.org/10.1016/j.drudis.2017.02.002
Drug Discovery Today
A considerable number of approved drugs show non-equilibrium binding characteristics, emphasizing the potential role of drug residence times for in vivo efficacy. Therefore, a detailed understanding of the kinetics of association and dissociation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f239e285cfffe51e30eaad7eaed15
https://doi.org/10.1016/j.drudis.2017.02.002
https://doi.org/10.1016/j.drudis.2017.02.002