Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Elena, Prigmore"'
Autor:
Gerda Kildisiute, Maria Kalyva, Rasa Elmentaite, Stijn van Dongen, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Elena Prigmore, Muzlifah Haniffa, Sarah A. Teichmann, Karin Straathof, Isidro Cortés-Ciriano, Sam Behjati, Matthew D. Young
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background As normal cells transform into cancers, their cell state changes, which may drive cancer cells into a stem-like or more primordial, foetal, or embryonic cell state. The transcriptomic profile of this final state may encode informa
Externí odkaz:
https://doaj.org/article/812f3b2924404e51948b8b5e13fcb34b
Autor:
Mi K. Trinh, Clarissa N. Pacyna, Gerda Kildisiute, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Nathaniel D. Anderson, Eleonora Khabirova, Elena Prigmore, Karin Straathof, Sam Behjati, Matthew D. Young
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
The identification of cancer cells from single cell transcriptomes can be improved by detecting allelic imbalances due to copy number changes.
Externí odkaz:
https://doaj.org/article/220e9b9e0e1441249c0e227b1bf2a3ec
Autor:
Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H. H. Coorens, Ignacio Del Valle, Anna Wilbrey-Clark, Lira Mamanova, Grant D. Stewart, Vincent J. Gnanapragasam, Dyanne Rampling, Neil Sebire, Nicholas Coleman, Liz Hook, Anne Warren, Muzlifah Haniffa, Marcel Kool, Stefan M. Pfister, John C. Achermann, Xiaoling He, Roger A. Barker, Adam Shlien, Omer A. Bayraktar, Sarah A. Teichmann, Frank C. Holstege, Kerstin B. Meyer, Jarno Drost, Karin Straathof, Sam Behjati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dediff
Externí odkaz:
https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a4
Autor:
Eugene J. Gardner, Elena Prigmore, Giuseppe Gallone, Petr Danecek, Kaitlin E. Samocha, Juliet Handsaker, Sebastian S. Gerety, Holly Ironfield, Patrick J. Short, Alejandro Sifrim, Tarjinder Singh, Kate E. Chandler, Emma Clement, Katherine L. Lachlan, Katrina Prescott, Elisabeth Rosser, David R. FitzPatrick, Helen V. Firth, Matthew E. Hurles
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Retrotransposition events have been linked to some human disorders. Here, Gardner et al. systematically search for mobile genetic elements (ME) in trio whole exome-sequencing datasets and ascertain 9 de novo MEs and further estimate genome-wide germl
Externí odkaz:
https://doaj.org/article/aa83ff40241c4c9a9ff87879eb6387cd
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Elena Prigmore, Louis-François Handfield, Michael R. Stratton, Tong Li, Mercedes Jimenez-Linan, Lucy Gardner, Luz Garcia-Alonso, Tarryn Porter, Krishnaa T. Mahbubani, Vitalii Kleshchevnikov, Anna Arutyunyan, Hassan Massalha, Monika Dabrowska, Paul Ayuk, Kwasi Kwakwa, Ashley Moffett, Benjamin Woodhams, Kourosh Saeb-Parsy, Ridma C. Fernando, Regina Hoo, Elizabeth Tuck, Konstantina Nikolakopoulou, Stijn van Dongen, Valentina Lorenzi, Jong-Eun Park, Kenny Roberts, Cecilia Icoresi Mazzeo, Margherita Y. Turco, Vasyl Vaskivskyi, Martin Prete, Aleksandra Tarkowska, Roser Vento-Tormo, Krzysztof Polanski, Carmen Sancho-Serra, Cecilia Lindskog, Omer Ali Bayraktar, Vladimir Yu. Kiselev, Sarah A. Teichmann, Lia S. Campos, Luiza Moore
Publikováno v:
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and three-dimensional endo
Autor:
Gerda Kildisiute, Maria Kalyva, Rasa Elmentaite, Stijn van Dongen, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Elena Prigmore, Muzlifah Haniffa, Sarah A. Teichmann, Karin Straathof, Isidro Cortés-Ciriano, Sam Behjati, Matthew D. Young
As normal cells transform into cancers, their cell state changes (or “dedifferentiates”), which may drive cancer cells into a stem-like or more primordial, foetal or embryonic cell state. Here, we used single cell atlases to study dedifferentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde57ebc1738ad6ce297a35ed10463b4
https://doi.org/10.1101/2022.11.28.518191
https://doi.org/10.1101/2022.11.28.518191
Autor:
Javier Rodríguez-Ubreva, Louis-Francois Handfield, Baerbel Keller, Laura Ciudad, Carlos de la Calle-Fabregat, Gerard Godoy-Tena, Josep Calafell-Segura, Eduardo Andrés-León, Regina Hoo, Tarryn Porter, Elena Prigmore, Maike Hofmann, Annegrit Decker, Javier Martín, Klaus Warnatz, Roser Vento-Tormo, Esteban Ballestar
Patients with common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, are characterized by hypogammaglobulinemia, poorly protective vaccine titers and increased susceptibility to infections. New pathogens suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307c107f51fed2756585410eb06bca86
http://hdl.handle.net/10261/307726
http://hdl.handle.net/10261/307726
Autor:
Veronika R. Kedlian, Yaning Wang, Tianliang Liu, Xiaoping Chen, Liam Bolt, Zhuojian Shen, Eirini S. Fasouli, Elena Prigmore, Vitalii Kleshchevnikov, Tong Li, John E Lawrence, Ni Huang, Qin Guo, Lu Yang, Krzysztof Polański, Monika Dabrowska, Catherine Tudor, Xiaobo Li, Omer Bayraktar, Minal Patel, Kerstin B. Meyer, Natsuhiko Kumasaka, Krishnaa T. Mahbubani, Andy Peng Xiang, Kourosh Saeb-Parsy, Sarah A Teichmann, Hongbo Zhang
Skeletal muscle ageing increases the incidence of age-associated frailty and sarcopenia in the elderly worldwide, leading to increased morbidity and mortality. However, our understanding of the cellular and molecular mechanisms of muscle ageing is st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30ff6d44870bf32b0d34ea3caa423fe
https://doi.org/10.1101/2022.05.24.493094
https://doi.org/10.1101/2022.05.24.493094
Autor:
Kerstin Meyer, Elo Madissoon, Amanda Oliver, Vitalii Kleshchevnikov, Anna Wilbrey-Clark, Krzysztof Polański, Nathan Richoz, Ana Elisa Ribeiro Orsi, Lira Mamanova, Liam Bolt, Rasa Elmentaite, Jan Pett, Ni Huang, Chuan Xu, Peng He, Monika Dabrowska, Sophie Pritchard, Elizabeth Tuck, Elena Prigmore, Shani Perera, Andrew Knights, Agnes Oszlanczi, Adam Hunter, Sara Filipa Vieira, Minal Patel, Masahiro Yoshida, Kaylee Worlock, Rik Lindeboom, Marko Nikolic, Nikitas Georgakopoulos, Krishna Mahbubani, Kourosh Saeb-Parsy, Omer Ali Bayraktar, Menna Clatworthy, Oliver Stegle, Natsuhiko Kumasaka, Sarah Teichmann
To (re)define tissue architecture of the lung and airways at the cellular and molecular level, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and Visium Spatial Transcriptomics. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc360382d632f87b2aa4fbae3cabbbc
https://doi.org/10.21203/rs.3.rs-1650134/v1
https://doi.org/10.21203/rs.3.rs-1650134/v1