Improving genome quality through artificial truncating purifying selection using heat shock: case of carps

Autor: Aleksandr Kuzmin, Vinogradov Evgenii, Dmitrii Balashov, Elena Kozenkova, Dmitrii Iliushchenko, Alina G. Mikhailova, Nataliya Patlay, Zakharenko Ekaterina, Kozenkov Ivan, Ptashnik Ivan, Valeriia Timonina, Evgenii Tretiakov, Yan Galimov, Christoph Haag, Bogdan Efimenko, Konstantin Gunbin, Igor Mizgirev, Nikolai Mugue, Konstantin Popadin

The process of domestication is associated with decrease in effective population size, which in turn leads to accumulation of slightly-deleterious mutations due to genetic drift. To maintain genome quality at a high level, we propose to use a stress-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4179940803ae4ce0e5ae38c03307ec83
https://doi.org/10.1101/2023.01.20.524958

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Autor: Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, Elena Kozenkova, Evgeny M Zdobnov, Vsevolod Makeev, Valerian Yurov, Masashi Tanaka, Irina Gostimskaya, Zoe Fleischmann, Sofia Annis, Melissa Franco, Kevin Wasko, Stepan Denisov, Wolfram S Kunz, Dmitry Knorre, Ilya Mazunin, Sergey Nikolaev, Jacques Fellay, Alexandre Reymond, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: Denisov, S 2022, ' A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand ', Nucleic acids research, vol. 50, pp. 10264–10277 . https://doi.org/10.1093/nar/gkac779

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaf04f68180d9afc181527a26230b3c
https://doi.org/10.1093/nar/gkac779

Multifunctional Fe

Autor: Elena, Kozenkova, Kateryna, Levada, Maria V, Efremova, Alexander, Omelyanchik, Yulia A, Nalench, Anastasiia S, Garanina, Stanislav, Pshenichnikov, Dmitry G, Zhukov, Oleg, Lunov, Mariia, Lunova, Ivan, Kozenkov, Claudia, Innocenti, Martin, Albino, Maxim A, Abakumov, Claudio, Sangregorio, Valeria, Rodionova

Publikováno v: Nanomaterials

Heterodimeric nanoparticles comprising materials with different functionalities are of great interest for fundamental research and biomedical/industrial applications. In this work, Fe3O4-Au nano-heterostructures were synthesized by a one-step thermal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3f490ea20f24cdd5a968abf69b68fa7
https://pubmed.ncbi.nlm.nih.gov/32825748