Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β

Autor: Chiara Lanzillotta, Antonella Tramutola, Simona Lanzillotta, Viviana Greco, Sara Pagnotta, Caterina Sanchini, Silvia Di Angelantonio, Elena Forte, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Flavia Agata Cimini, Ilaria Barchetta, Maria Gisella Cavallo, Andrea Urbani, D. Allan Butterfield, Fabio Di Domenico, Bindu D. Paul, Marzia Perluigi, Joao M.N. Duarte, Eugenio Barone

Publikováno v: Redox Biology, Vol 73, Iss , Pp 103221- (2024)

Brain insulin resistance links the failure of energy metabolism with cognitive decline in both type 2 Diabetes Mellitus (T2D) and Alzheimer's disease (AD), although the molecular changes preceding overt brain insulin resistance remain unexplored. Abn

Externí odkaz: https://doaj.org/article/981f6d63b120410193df144c24aca2cc

ROS Defense Systems and Terminal Oxidases in Bacteria

Autor: Vitaliy B. Borisov, Sergey A. Siletsky, Martina R. Nastasi, Elena Forte

Publikováno v: Antioxidants, Vol 10, Iss 6, p 839 (2021)

Reactive oxygen species (ROS) comprise the superoxide anion (O2•−), hydrogen peroxide (H2O2), hydroxyl radical (•OH), and singlet oxygen (1O2). ROS can damage a variety of macromolecules, including DNA, RNA, proteins, and lipids, and compromise

Externí odkaz: https://doaj.org/article/65802faf26e1498cbea4ff45536f4a9f

N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells

Autor: Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè

Publikováno v: Cells, Vol 8, Iss 8, p 828 (2019)

Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), bes

Externí odkaz: https://doaj.org/article/1f05ae45fda74332904ade2530a68b1d

In Escherichia coli Ammonia Inhibits Cytochrome bo3 But Activates Cytochrome bd-I

Autor: Elena Forte, Vitaliy B. Borisov, Sergey A. Siletsky

Publikováno v: Antioxidants, Vol 10, Iss 13, p 13 (2021)
Antioxidants
Volume 10
Issue 1

Interaction of two redox enzymes of Escherichia coli, cytochrome bo3 and cytochrome bd-I, with ammonium sulfate/ammonia at pH 7.0 and 8.3 was studied using high-resolution respirometry and absorption spectroscopy. At pH 7.0, the oxygen reductase acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a7a5d7b346e647fca2fe1bf840019e
https://www.mdpi.com/2076-3921/10/1/13

Bacterial oxidases of the cytochrome bd family: redox enzymes of unique structure, function, and utility as drug targets

Autor: Robert K. Poole, Alessandro Paiardini, Elena Forte, Sergey A. Siletsky, Vitaliy B. Borisov, Alessandro Giuffrè, David Hoogewijs

Publikováno v: Antioxidants & redox signalling 34 (2021): 1280–1318. doi:10.1089/ars.2020.8039
info:cnr-pdr/source/autori:Borisov, Vitaliy B.; Siletsky, Sergey A.; Paiardini, Alessandro; Hoogewijs, David; Forte, Elena; Giuffrè, Alessandro; Poole, Robert K./titolo:Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets/doi:10.1089%2Fars.2020.8039/rivista:Antioxidants & redox signalling/anno:2021/pagina_da:1280/pagina_a:1318/intervallo_pagine:1280–1318/volume:34

Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652c0ca55a0e484942e5662e04f97dd8
http://doc.rero.ch/record/329903/files/hoo_boc.pdf