Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Elen Mello de Souza"'
Autor:
Roberto Rodrigues Ferreira, Elen Mello de Souza, Glaucia Vilar-Pereira, Wim M. S. Degrave, Rayane da Silva Abreu, Marcelo Meuser-Batista, Nilma Valéria Caldeira Ferreira, Steve Ledbeter, Robert H. Barker, Sabine Bailly, Jean-Jacques Feige, Joseli Lannes-Vieira, Tania C. de Araújo-Jorge, Mariana Caldas Waghabi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas disease, a neglected tropical disease caused by Trypanosoma cruzi infection. During CCC, the parasite remains insid
Externí odkaz:
https://doaj.org/article/e96a0e4a824f40eaa385d90cfb0289da
Autor:
Mariana Caldas Waghabi, Roberto Rodrigues Ferreira, Rayane da Silva Abreu, Wim Degrave, Elen Mello de Souza, Sabine Bailly, Jean-Jacques Feige, Tania C de Araújo-Jorge
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 117 (2022)
Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Importan
Externí odkaz:
https://doaj.org/article/6c3830196cbb46bfa0e4b9186f06b89d
Autor:
Roberto Rodrigues Ferreira, Rayane da Silva Abreu, Glaucia Vilar-Pereira, Wim Degrave, Marcelo Meuser-Batista, Nilma Valéria Caldeira Ferreira, Otacílio da Cruz Moreira, Natália Lins da Silva Gomes, Elen Mello de Souza, Isalira P Ramos, Sabine Bailly, Jean-Jacques Feige, Joseli Lannes-Vieira, Tania C de Araújo-Jorge, Mariana Caldas Waghabi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007602 (2019)
TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling pathway is activated in the cardiac tissue of chronic phase patients and is associated with an increase in extracellular matrix protein expression
Externí odkaz:
https://doaj.org/article/3736842f86a242e598ff553363a576b7
Autor:
Audrien Alves Andrade de Souza, Lauana Ribas Torres, Lyana Rodrigues Pinto Lima Capobianco, Vanessa Salete de Paula, Cynthia Machado Cascabulho, Kelly Salomão, Maria da Gloria Bonecini-Almeida, Maria de Lourdes Garcia Ferreira, Nubia Boechat, Luiz Carlos da Silva Pinheiro, Elen Mello de Souza
Publikováno v:
Viruses, Vol 13, Iss 1, p 36 (2020)
Despite the severe morbidity caused by Zika fever, its specific treatment is still a challenge for public health. Several research groups have investigated the drug repurposing of chloroquine. However, the highly toxic side effect induced by chloroqu
Externí odkaz:
https://doaj.org/article/180e4b09a3974142a0daf3023f219ceb
Autor:
Debora Ferreira Barreto-Vieira, Fernanda Cunha Jácome, Marcos Alexandre Nunes da Silva, Gabriela Cardoso Caldas, Ana Maria Bispo de Filippis, Patrícia Carvalho de Sequeira, Elen Mello de Souza, Audrien Alves Andrade, Pedro Paulo de Abreu Manso, Gisela Freitas Trindade, Sheila Maria Barbosa Lima, Ortrud Monika Barth
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184397 (2017)
Zika virus (ZIKV) is a member of the flavivirus genus, and its genome is approximately 10.8 kilobases of positive-strand RNA enclosed in a capsid and surrounded by a membrane. Studies on the replication dynamics of ZIKV are scarce, which limits the d
Externí odkaz:
https://doaj.org/article/a6abf74ba9dc4c45b6f4c2612621bb4d
Autor:
Elen Mello de Souza, Andrea Henriques-Pons, Christian Bailly, Amelie Lansiaux, Tânia Cremonine Araújo-Jorge, Maria de Nazaré Correia Soeiro
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 99, Iss 7, Pp 697-701 (2004)
Primary cultures of cardiomyocytes represent a useful model for analyzing cardiac cell biology as well as pathogenesis of several cardiovascular disorders. Our aim was to standardize protocols for determining the damage of cardiac cells cultured in v
Externí odkaz:
https://doaj.org/article/ea761b7f0fe24da4bece0d56ca7a29cd
Autor:
Lindice Mitie Nisimura, Vanessa Estato, Elen Mello de Souza, Patricia A Reis, Marcos Adriano Lessa, Hugo Caire Castro-Faria-Neto, Mirian Claudia de Souza Pereira, Eduardo Tibiriçá, Luciana Ribeiro Garzoni
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2998 (2014)
Cardiomyopathy is the main clinical form of Chagas disease (CD); however, cerebral manifestations, such as meningoencephalitis, ischemic stroke and cognitive impairment, can also occur. The aim of the present study was to investigate functional micro
Externí odkaz:
https://doaj.org/article/5805a28f79a242b6a0cad6706d1d2138
Autor:
Cristiane França da Silva, Denise da Gama Jaen Batista, Gabriel Melo Oliveira, Elen Mello de Souza, Erica Ripoll Hammer, Patricia Bernardino da Silva, Anissa Daliry, Julianna Siciliano Araujo, Constança Britto, Ana Carolina Mondaine Rodrigues, Zongying Liu, Abdelbasset A Farahat, Arvind Kumar, David W Boykin, Maria de Nazaré Correia Soeiro
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30356 (2012)
Chagas disease is caused by infection with the intracellular protozoan parasite Trypanosoma cruzi. At present, nifurtimox and benznidazole, both compounds developed empirically over four decades ago, represent the chemotherapeutic arsenal for treatin
Externí odkaz:
https://doaj.org/article/6ecd080e6932474c868b15114ac95282
Autor:
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto‐Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza
Publikováno v:
Journal of medical virology. 94(9)
Dengue fever, caused by the dengue virus (DENV-1, -2, -3, and -4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming gr
Autor:
Lindice Mitie Nisimura, Roberto Rodrigues Ferreira, Laura Lacerda Coelho, Elen Mello de Souza, Beatriz Matheus Gonzaga, Patrícia Mello Ferrão, Mariana Caldas Waghabi, Liliane Batista de Mesquita, Mirian Claudia de Souza Pereira, Otacilio da Cruz Moreira, Joseli Lannes-Vieira, Luciana Ribeiro Garzoni
Publikováno v:
Memórias do Instituto Oswaldo Cruz, Volume: 117, Article number: e220005, Published: 21 NOV 2022
BACKGROUND Angiogenesis has been implicated in tissue injury in several noninfectious diseases, but its role in Chagas disease (CD) physiopathology is unclear. OBJECTIVES The present study aimed to investigate the effect of Trypanosoma cruzi infectio