Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Eleftherios Pilalis"'
Autor:
Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lip
Externí odkaz:
https://doaj.org/article/5880a9d0a80d435dbe79e1dfb4bc9b6f
Autor:
Verona Buocikova, Silvia Tyciakova, Eleftherios Pilalis, Chara Mastrokalou, Maria Urbanova, Miroslava Matuskova, Lucia Demkova, Veronika Medova, Eleonora Marta Longhin, Elise Rundén-Pran, Maria Dusinska, Ivan Rios-Mondragon, Mihaela Roxana Cimpan, Alena Gabelova, Andrea Soltysova, Bozena Smolkova, Aristotelis Chatziioannou
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising avenue in treating resistant ca
Externí odkaz:
https://doaj.org/article/5bc2b77aace34b56b39120aa94a4b5ef
Autor:
Verona Buocikova, Eleonora Marta Longhin, Eleftherios Pilalis, Chara Mastrokalou, Svetlana Miklikova, Marina Cihova, Alexandra Poturnayova, Katarina Mackova, Andrea Babelova, Lenka Trnkova, Naouale El Yamani, Congying Zheng, Ivan Rios-Mondragon, Martina Labudova, Lucia Csaderova, Kristina Mikus Kuracinova, Peter Makovicky, Lucia Kucerova, Miroslava Matuskova, Mihaela Roxana Cimpan, Maria Dusinska, Pavel Babal, Aristotelis Chatziioannou, Alena Gabelova, Elise Rundén-Pran, Bozena Smolkova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 147, Iss , Pp 112662- (2022)
Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer cells to other therapies, prov
Externí odkaz:
https://doaj.org/article/1345e26c32b84eee948affb57a4afc4c
Autor:
Ilona Binenbaum, Hanifa Abu-Toamih Atamni, Georgios Fotakis, Georgia Kontogianni, Theodoros Koutsandreas, Eleftherios Pilalis, Richard Mott, Heinz Himmelbauer, Fuad A. Iraqi, Aristotelis A. Chatziioannou
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background The Collaborative Cross (CC) mouse population is a valuable resource to study the genetic basis of complex traits, such as obesity. Although the development of obesity is influenced by environmental factors, underlying genetic mec
Externí odkaz:
https://doaj.org/article/71f0522f8c4c4f4faafbdd48e7b5aa21
Autor:
Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 6, Pp 1-19 (2019)
Abstract Anterior gradient 2 (AGR2) is a dimeric protein disulfide isomerase family member involved in the regulation of protein quality control in the endoplasmic reticulum (ER). Mouse AGR2 deletion increases intestinal inflammation and promotes the
Externí odkaz:
https://doaj.org/article/2b0499d0c4e74f49840a1110c75b673e
Autor:
Efstathios–Iason Vlachavas, Eleftherios Pilalis, Olga Papadodima, Dirk Koczan, Stefan Willis, Sven Klippel, Caixia Cheng, Leyun Pan, Christos Sachpekidis, Alexandros Pintzas, Vasilis Gregoriou, Antonia Dimitrakopoulou-Strauss, Aristotelis Chatziioannou
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 177-185 (2019)
Purpose: Transcriptomic profiling has enabled the neater genomic characterization of several cancers, among them colorectal cancer (CRC), through the derivation of genes with enhanced causal role and informative gene sets. However, the identification
Externí odkaz:
https://doaj.org/article/446f8b62f1804badb9ee797725a5ef2f
Autor:
Marianthi Logotheti, Eleftherios Pilalis, Nikolaos Venizelos, Fragiskos Kolisis, Aristotelis Chatziioannou
Publikováno v:
AIMS Bioengineering, Vol 3, Iss 4, Pp 552-565 (2016)
Gene expression profiles of non-neural tissues through microarray technology could be used in schizophrenia studies, adding more information to the results from similar studies on postmortem brain tissue. The ultimate goal of such studies is to devel
Externí odkaz:
https://doaj.org/article/0c7ae86d69a34a5fb8049cc381e8e11f
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Phage Display is a powerful method for the identification of peptide binding to targets of variable complexities and tissues, from unique molecules to the internal surfaces of vessels of living organisms. Particularly for in vivo screenings, the resu
Externí odkaz:
https://doaj.org/article/a73ebf520ed149b78d5b4d5d8ab58be3
Autor:
Theodoros Koutsandreas, Efthymios Ladoukakis, Eleftherios Pilalis, Dimitra Zarafeta, Fragiskos N. Kolisis, Georgios Skretas, Aristotelis A. Chatziioannou
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Metagenomic analysis of environmental samples provides deep insight into the enzymatic mixture of the corresponding niches, capable of revealing peptide sequences with novel functional properties exploiting the high performance of next-generation seq
Externí odkaz:
https://doaj.org/article/222339b77c634d27950e282d8f5e596d
Autor:
Eleftherios Pilalis, Theodoros Koutsandreas, Ioannis Valavanis, Emmanouil Athanasiadis, George Spyrou, Aristotelis Chatziioannou
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 248-255 (2015)
Gene expression analysis, using high throughput genomic technologies,has become an indispensable step for the meaningful interpretation of the underlying molecular complexity, which shapes the phenotypic manifestation of the investigated biological m
Externí odkaz:
https://doaj.org/article/5f4c6e5d250640bcb860feca77fc5867