Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity

Autor: Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea

Publikováno v: Critical Care, Vol 27, Iss 1, Pp 1-6 (2023)

Abstract Background Sepsis is characterized by a dysregulated immune response to infection. The complement system plays an important role in the host defence to pathogens. However, exaggerated complement activation might contribute to a hyperinflamma

Externí odkaz: https://doaj.org/article/810ce46bbdd44659a06b09fba2fbb680

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Autor: Evdoxia Kyriazopoulou, Thomas Huet, Giulio Cavalli, Andrea Gori, Miltiades Kyprianou, Peter Pickkers, Jesper Eugen-Olsen, Mario Clerici, Francisco Veas, Gilles Chatellier, Gilles Kaplanski, Mihai G Netea, Emanuele Pontali, Marco Gattorno, Raphael Cauchois, Emma Kooistra, Matthijs Kox, Alessandra Bandera, Hélène Beaussier, Davide Mangioni, Lorenzo Dagna, Jos W M van der Meer, Evangelos J Giamarellos-Bourboulis, Gilles Hayem, Mihai G. Netea, Jos W.M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Stefano Volpi, Maria Pia Sormani, Alessio Signori, Giorgio Bozzi, Francesca Minoia, Stefano Aliberti, Giacomo Grasselli, Laura Alagna, Andrea Lombardi, Riccardo Ungaro, Carlo Agostoni, Francesco Blasi, Giorgio Costantino, Anna Ludovica Fracanzani, Nicola Montano, Flora Peyvandi, Marcello Sottocorno, Antonio Muscatello, Giovanni Filocamo, Antonios Papadopoulos, Maria Mouktaroudi, Eleni Karakike, Maria Saridaki, Theologia Gkavogianni, Konstantina Katrini, Nikolaos Vechlidis, Christina Avgoustou, Stamatios Chalvatzis, Theodoros Marantos, Christina Damoulari, Georgia Damoraki, Sofia Ktena, Maria Tsilika, Panagiotis Koufargyris, Athanasios Karageorgos, Dionysia-Irene Droggiti, Aikaterini Koliakou, Garyfallia Poulakou, Konstantinos Tsiakos, Dimitra-Melia Myrodia, Areti Gravvani, Ioannis P. Trontzas, Konstantinos Syrigos, Ioannis Kalomenidis, Eleftheria Kranidioti, Periklis Panagopoulos, Vasileios Petrakis, Simeon Metallidis, Georgia Loli, Olga Tsachouridou, George N. Dalekos, Nikolaos Gatselis, Aggelos Stefos, Sarah Georgiadou, Vassiliki Lygoura, Haralampos Milionis, Maria Kosmidou, Ilias C. Papanikolaou, Karolina Akinosoglou, Efthymia Giannitsioti, Georgios Chrysos, Panagiotis Mavroudis, Chrysanthi Sidiropoulou, Georgios Adamis, Archontoula Fragkou, Aggeliki Rapti, Zoi Alexiou, Styliani Symbardi, Aikaterini Masgala, Konstantina Kostaki, Evangelos Kostis, Michael Samarkos, Petros Bakakos, Vassiliki Tzavara, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Vasileios Kotsis, George Tsoukalas, Ioannis Bliziotis, Michael Doumas, Aikaterini Argyraki, Ilias Kainis, Massimo Fantoni, Antonella Cingolani, Andrea Angheben, Chiara Simona Cardellino, Francesco Castelli, Francesco Saverio Serino, Emanuele Nicastri, Giuseppe Ippolito, Matteo Bassetti, Carlo Selmi

Publikováno v: The Lancet. Rheumatology, 3, e690-e697
The Lancet Rheumatology
The Lancet Rheumatology, 2021, 3 (10), pp.e690-e697. ⟨10.1016/S2665-9913(21)00216-2⟩
The Lancet. Rheumatology
The Lancet. Rheumatology, 3, 10, pp. e690-e697

Contains fulltext : 237989.pdf (Publisher’s version ) (Closed access) BACKGROUND: Anakinra might improve the prognosis of patients with moderate to severe COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279ea0e8e7c073b4db170de25ba89792
https://hdl.handle.net/2066/237989

Moderate COVID-19: Clinical Trajectories and Predictors of Progression and Outcomes

Autor: Apostolos G. Pappas, Andreas Panagopoulos, Artemis Rodopoulou, Michaella Alexandrou, Anna-Louiza Chaliasou, Konstantinos Skianis, Eleftheria Kranidioti, Eleftheria Chaini, Ilias Papanikolaou, Ioannis Kalomenidis

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 9; Pages: 1472

Background: Patients with COVID-19 commonly present at healthcare facilities with moderate disease, i.e., pneumonia without a need for oxygen therapy. Aim: To identify clinical/laboratory characteristics of patients with moderate COVID-19, which coul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb8024d7f7fe26f3b6576e256ad501a
https://doi.org/10.3390/jpm12091472

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Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis

Autor: Eleftheria Kranidioti, Sofia Katsila, Michael Samarkos, Christodoulos Dolapsakis

Publikováno v: BMJ Case Rep

We report a case of septic thrombosis of the right cavernous sinus in a diabetic woman in her late 70’s due to ipsilateral sphenoid sinusitis. The diagnosis was delayed and made only after the abrupt and dramatic appearance of the manifestations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd764f1724bfe32cb1af2374345a7991
https://doi.org/10.1136/bcr-2018-227302