Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Eleftheria Diakogiannaki"'
Autor:
Fiona M. Gribble, Eleftheria Diakogiannaki, Leslie L Glass, Catherine E. Moss, Carol Lenaghan, Marianne Wedin, Mohammad Bohlooly-Y, David M. Smith, Ramona Pais, Frank Reimann
Publikováno v:
Peptides
Highlights • GPR119, a putative fat sensor, is a potential target for metabolic disease. • KO of GPR119 in murine L-cells reduced GLP-1 response to fat in vivo. • Primary L-cells secreted GLP-1 in response to GPR119 agonists. • GPR119 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2db20a6d3b53ae9ed4b408432d27c5
Publikováno v:
Peptides. 125:170206
Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312e2e179e3fa0f87e56e20d697333cc
https://doi.org/10.1016/j.peptides.2019.170206
https://doi.org/10.1016/j.peptides.2019.170206
Autor:
Frank Reimann, Gwen Tolhurst, Tamara Zietek, Fiona M. Gribble, Helen E. Parker, Hannelore Daniel, Eleftheria Diakogiannaki, Ramona Pais, Beate Rauscher, James A. Horscroft
Publikováno v:
Diabetologia
Aims/hypothesis Ingested protein is a well-recognised stimulus for glucagon-like peptide-1 (GLP-1) release from intestinal L cells. This study aimed to characterise the molecular mechanisms employed by L cells to detect oligopeptides. Methods GLP-1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6aaff85e1da3a585e2c863405c0531
http://europepmc.org/articles/PMC3825574
http://europepmc.org/articles/PMC3825574
Publikováno v:
Free Fatty Acid Receptors ISBN: 9783319506920
The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980574d7bab2a4a75b0d41238404c3cb
https://doi.org/10.1007/164_2016_46
https://doi.org/10.1007/164_2016_46
Autor:
Fiona M. Gribble, Abdella M. Habib, Frank Reimann, Eleftheria Diakogiannaki, Helen E. Parker, Gwen Tolhurst, Helen Heffron, Yu Shan Lam, Johannes Grosse, Jennifer Cameron
Publikováno v:
Diabetes
Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a06844111e2f2768d3fb67e419eeba
https://doi.org/10.2337/db11-1019
https://doi.org/10.2337/db11-1019
Publikováno v:
Biochemical Society Transactions. 36:905-908
Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence of Type 2 diabetes in humans.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1af72e8dc3b5346bcc49e5d1a68329
https://doi.org/10.1042/bst0360905
https://doi.org/10.1042/bst0360905
Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic β-cell
Publikováno v:
Biochemical Society Transactions. 36:959-962
Recent evidence indicates that treatment of pancreatic beta-cells with long chain fatty acids can lead to the development of an ER (endoplasmic reticulum) stress response. This is manifest as the activation of some components of the PERK [RNA-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bff8d55d6d73f6d4433506ccbb3ebf9
https://doi.org/10.1042/bst0360959
https://doi.org/10.1042/bst0360959
Autor:
Stuart Bevan, Frank Gribble, Fiona Mary Reimann, Edward C. Emery, Michael Fischer, Eleftheria Diakogiannaki, Abdella M. Habib, Clive Gentry, Arianna Psichas
Stimulus-coupled incretin secretion from enteroendocrine cells plays a fundamental role in glucose homeostasis, and could be targeted for the treatment of type-2 diabetes. Here, we investigated the expression and function of transient receptor potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edf98c65ae8c22a59b59cd3a0a85f22
https://www.repository.cam.ac.uk/handle/1810/246213
https://www.repository.cam.ac.uk/handle/1810/246213
Autor:
Hannah J. Welters, Eleftheria Diakogiannaki, Stephen A. Smith, J. Mark Mordue, Noel G. Morgan, Moh Tadayyon
Publikováno v:
Apoptosis. 11:1231-1238
Saturated and mono-unsaturated fatty acids exert differential effects on pancreatic beta-cell viability during chronic exposure. Long chain saturated molecules (e.g. palmitate) are cytotoxic to beta-cells and this is associated with caspase activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e954c60527ad6a1ef3791e645088f4a
https://doi.org/10.1007/s10495-006-7450-7
https://doi.org/10.1007/s10495-006-7450-7
Autor:
Karen A, Johnstone, Eleftheria, Diakogiannaki, Shalinee, Dhayal, Noel G, Morgan, Lorna W, Harries
Publikováno v:
JOP : Journal of the pancreas. 12(1)
Increased levels of circulating fatty acids deriving from over-nutrition are thought to contribute to the progressive beta-cell failure associated with type 2 diabetes. Pancreatic beta-cells in culture are sensitive to exposure to long-chain saturate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fcaf615d3710ce723e6e863bed854e8
https://pubmed.ncbi.nlm.nih.gov/21206094
https://pubmed.ncbi.nlm.nih.gov/21206094