Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eleen Y. Shum"'
Autor:
Hye-Won Song, Anilkumar Bettegowda, Blue B. Lake, Adrienne H. Zhao, David Skarbrevik, Eric Babajanian, Meena Sukhwani, Eleen Y. Shum, Mimi H. Phan, Terra-Dawn M. Plank, Marcy E. Richardson, Madhuvanthi Ramaiah, Vaishnavi Sridhar, Dirk G. de Rooij, Kyle E. Orwig, Kun Zhang, Miles F. Wilkinson
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 149-164 (2016)
The developmental origins of most adult stem cells are poorly understood. Here, we report the identification of a transcription factor—RHOX10—critical for the initial establishment of spermatogonial stem cells (SSCs). Conditional loss of the enti
Externí odkaz:
https://doaj.org/article/6d7587bd1d6544e09806e0302cbca845
Autor:
Chih-Hong Lou, Jennifer Dumdie, Alexandra Goetz, Eleen Y. Shum, David Brafman, Xiaoyan Liao, Sergio Mora-Castilla, Madhuvanthi Ramaiah, Heidi Cook-Andersen, Louise Laurent, Miles F. Wilkinson
Publikováno v:
Stem Cell Reports, Vol 6, Iss 6, Pp 844-857 (2016)
Summary: Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend t
Externí odkaz:
https://doaj.org/article/98086608a1714f32a8e3dc874d165deb
Autor:
Chih H. Lou, Ada Shao, Eleen Y. Shum, Josh L. Espinoza, Lulu Huang, Rachid Karam, Miles F. Wilkinson
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 748-764 (2014)
The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA decay (NMD) pathway, plays a key ro
Externí odkaz:
https://doaj.org/article/c99fdc0f1b754aae9f2600ece6fa0f80
Autor:
Kun Tan, Samantha H Jones, Blue B Lake, Jennifer N Chousal, Eleen Y Shum, Lingjuan Zhang, Song Chen, Abhishek Sohni, Shivam Pandya, Richard L Gallo, Kun Zhang, Heidi Cook-Andersen, Miles F Wilkinson
Publikováno v:
eLife, Vol 9 (2020)
The UPF3B-dependent branch of the nonsense-mediated RNA decay (NMD) pathway is critical for human cognition. Here, we examined the role of UPF3B in the olfactory system. Single-cell RNA-sequencing (scRNA-seq) analysis demonstrated considerable hetero
Externí odkaz:
https://doaj.org/article/8a0c1bf4ffd94ebebb77c22183768b09
Autor:
Eleen Y. Shum, Janice H. Lai, Sixing Li, Haeun G. Lee, Jesse Soliman, Vedant K. Raol, Cavina K. Lee, Stephen P.A. Fodor, H. Christina Fan
Publikováno v:
Analytical chemistry. 94(51)
Digital PCR (dPCR) was first conceived for single-molecule quantitation. However, current dPCR systems often require DNA templates to share partitions due to limited partitioning capacities. Here, we introduce UltraPCR, a next-generation dPCR system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196fccb6bc85a7fd6fc5d304f20dac9d
https://pubmed.ncbi.nlm.nih.gov/36508568
https://pubmed.ncbi.nlm.nih.gov/36508568
Autor:
Eleen Y. Shum, Janice H. Lai, Sixing Li, Haeun G. Lee, Jesse Soliman, Vedant K. Raol, Cavina K. Lee, Stephen P.A. Fodor, H. Christina Fan
Digital PCR (dPCR) was first conceived for single molecule quantitation. However, current dPCR systems often require DNA templates to share partitions due to limited partitioning capacities. Here, we introduce Ultra-dPCR, a next generation dPCR syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb8cec3514cf94be0495ccac9b503df
https://doi.org/10.1101/2022.08.01.502071
https://doi.org/10.1101/2022.08.01.502071
Publikováno v:
Advances in experimental medicine and biology. 1129
In this review, we describe the BD Rhapsody™ Single-Cell Analysis System, a platform that allows high-throughput capture of nucleic acids from single cells using a simple cartridge workflow and a multitier barcoding system. The resulting captured i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08de485aaf75d3e83985659f289207f3
https://pubmed.ncbi.nlm.nih.gov/30968361
https://pubmed.ncbi.nlm.nih.gov/30968361
Autor:
Nidhanjali Bansal, Christina Chang, Yuqiong Liang, Eleen Y. Shum, Jody C. Martin, James Ghadiali, Devon Jensen, Jing Hu, David Rosenfeld, Ye Zheng, H. Christina Fan
Publikováno v:
The Journal of Immunology. 200:120.11-120.11
Diverse immune populations reside in non-lymphoid organs and contribute to immune defense and tissue homeostasis. However, these cells are often hard to study due to low cell abundance and high heterogeneity. Recent advancements in single-cell sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5af21808ac190c27c130f0376c687d7
https://doi.org/10.4049/jimmunol.200.supp.120.11
https://doi.org/10.4049/jimmunol.200.supp.120.11
Autor:
Christina Chang, Eleen Y Shum, Nidhanjali Bansal, Joanna Dreux, Gretchen Lam, Jue Fan, H. Christina Fan
Publikováno v:
The Journal of Immunology. 198:157.15-157.15
CD4 T cells are critical components of the adaptive immune system and can differentiate into specialized effector subsets to mediate immune response against a wide host of pathogens. Studying the transcriptional profile of distinct T helper subsets h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71c1ec04e92fca47b975e781dcc87c89
https://doi.org/10.4049/jimmunol.198.supp.157.15
https://doi.org/10.4049/jimmunol.198.supp.157.15