Interleukin-6 Elevation Is a Key Pathogenic Factor Underlying COVID-19-Associated Heart Rate-Corrected QT Interval Prolongation

Autor: Pietro Enea Lazzerini, Riccardo Accioli, Maurizio Acampa, Wen-Hui Zhang, Decoroso Verrengia, Alessandra Cartocci, Maria Romana Bacarelli, Xiaofeng Xin, Viola Salvini, Ke-Su Chen, Fabio Salvadori, Antonio D’errico, Stefania Bisogno, Gabriele Cevenini, Tommaso Marzotti, Matteo Capecchi, Franco Laghi-Pasini, Long Chen, Pier Leopoldo Capecchi, Mohamed Boutjdir

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundHeart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes. Recent evidence suggests that the exaggerated host immune-inflammatory respon

Externí odkaz: https://doaj.org/article/85e7c6f8ac0c4831a8a098f628e96ed0

Unravelling Atrioventricular Block Risk in Inflammatory Diseases: Systemic Inflammation Acutely Delays Atrioventricular Conduction via a Cytokine‐Mediated Inhibition of Connexin43 Expression

Autor: Pietro Enea Lazzerini, Maurizio Acampa, Michael Cupelli, Alessandra Gamberucci, Ujala Srivastava, Claudio Nanni, Iacopo Bertolozzi, Francesca Vanni, Alessandro Frosali, Anna Cantore, Alessandra Cartocci, Antonio D’Errico, Viola Salvini, Riccardo Accioli, Decoroso Verrengia, Fabio Salvadori, Aleksander Dokollari, Massimo Maccherini, Nabil El‐Sherif, Franco Laghi‐Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury. Indeed, gap‐junctions containing connexin43 coupling cardiomyocytes and inflammation‐related cells (m

Externí odkaz: https://doaj.org/article/1f2b7f51ebe44ba686a5749a44b38972

New Strategies for the Treatment of Atrial Fibrillation

Autor: Norbert Jost, Torsten Christ, János Magyar

Publikováno v: Pharmaceuticals, Vol 14, Iss 9, p 926 (2021)

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the clinical practice. It significantly contributes to the morbidity and mortality of the elderly population. Over the past 25–30 years intense effort in basic research has advanc

Externí odkaz: https://doaj.org/article/b57d2536f85247b3a0abf997798fc46a

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Unravelling Atrioventricular Block Risk in Inflammatory Diseases: Systemic Inflammation Acutely Delays Atrioventricular Conduction via a Cytokine-Mediated Inhibition of Connexin43 Expression

Autor: Alessandro Frosali, Decoroso Verrengia, Alessandra Gamberucci, Mohamed Boutjdir, Francesca Vanni, Franco Laghi-Pasini, Aleksander Dokollari, Pier Leopoldo Capecchi, Alessandra Cartocci, Maurizio Acampa, Nabil El-Sherif, Claudio Nanni, Antonio D'Errico, Pietro Enea Lazzerini, Ujala Srivastava, Iacopo Bertolozzi, Anna Cantore, Michael Cupelli, Fabio Salvadori, Viola Salvini, Riccardo Accioli, Massimo Maccherini

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury. Indeed, gap‐junctions containing connexin43 coupling cardiomyocytes and inflammation‐related cells (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a14dc0ad90d1930ab3b7ed13e58cc2a
https://pubmed.ncbi.nlm.nih.gov/34713715