Tyrosine kinase inhibition effects of novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines ligand: Synthesis, biological screening and molecular modeling studies.

Autor: El Sayed MT; Deparment of Applied Organic Chemistry, National Research Centre, 12622 Dokki, Egypt., Hussein HAR; Department of Photochemistry, National Research Centre, 12622 Dokki, Egypt., Elebiary NM; Department of Green Chemistry, National Research Centre, 12622 Dokki, Egypt., Hassan GS; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt. Electronic address: ghadasameh@mans.edu.eg., Elmessery SM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt., Elsheakh AR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt., Nayel M; National Cancer Institute, Chemotherapeutic Agents Repository, Fisher BioServices, Germantown, MD 20874, USA., Abdel-Aziz HA; Deparment of Applied Organic Chemistry, National Research Centre, 12622 Dokki, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2018 Aug; Vol. 78, pp. 312-323. Date of Electronic Publication: 2018 Mar 26.