Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Eleanor Y. M. Bonnist"'
Autor:
David S. Arnold, Graham Andrew Turner, Susan Bates, Teresa Robinson, Paul D. A. Pudney, Richard Livesey Evans, Eleanor Y. M. Bonnist, Robert E. Marriott, Darren M. Green
Publikováno v:
Archives of Dermatological Research. 309:739-748
The study objectives were to demonstrate that glycerol, when topically applied from a roll-on antiperspirant formulation, can be delivered directly to human skin ex vivo and the axillary stratum corneum (SC) in vivo, and to assess whether it improves
Autor:
Paul D. A. Pudney, Gerwin J. Puppels, Martin J. G. van der Wolf, Chris Marriot, Scott Singleton, Jean-Philippe Gorce, Eleanor Y. M. Bonnist, Peter J. Caspers
Publikováno v:
Applied Spectroscopy, 66(8), 882-891. SAGE Publishing
This paper describes a new in vivo Raman probe that allows investigation of areas of the body that are otherwise difficult to access. It is coupled to a previously described commercially available in vivo Raman spectrometer that samples the skin thro
Publikováno v:
Bonnist, E Y M, Liebert, K, Dryden, D T F, Jeltsch, A & Jones, A C 2012, ' Using the fluorescence decay of 2-aminopurine to investigate conformational change in the recognition sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on enzyme binding ', Biophysical Chemistry, vol. 160, no. 1, pp. 28-34 . https://doi.org/10.1016/j.bpc.2011.09.001
The EcoRV DNA methyltransferase methylates the first adenine in the GATATC recognition sequence. It is presumed that methylation proceeds by a nucleotide flipping mechanism but no crystal structure is available to confirm this. A popular solution-pha
Autor:
Simon Pitts, Michael van Ginkel, Ann-Marie Williamson, Peter J. McDonald, Scott Singleton, Eleanor Y. M. Bonnist, E Ciampi
Publikováno v:
NMR in Biomedicine. 24:135-144
We describe the development of in vivo one-dimensional MRI (profiling) using a GARField (Gradient At Right angles to Field) magnet for the characterisation of side-of-hand human skin. For the first time and in vivo, we report measurements of the NMR
Autor:
Eleanor Y. M. Bonnist, Anita C. Jones
Publikováno v:
Bonnist, E Y M & Jones, A C 2008, ' Long-wavelength fluorescence from 2-aminopurine-nucleobase dimers in DNA ', ChemPhysChem, vol. 9, no. 8, pp. 1121-1129 . https://doi.org/10.1002/cphc.200700813
When 2-aminopurine (2AP) is substituted for adenine in DNA, it is widely accepted that its fluorescence spectrum is essentially unchanged from that of the free fluorophore. We show that 2AP in DNA exhibits long-wavelength emission and excitation bond
Autor:
Thomas Lenz, Axel J. Scheidig, David T. F. Dryden, Elmar Weinhold, Eleanor Y. M. Bonnist, Goran Pljevaljcic, Robert K. Neely, Anita C. Jones
Publikováno v:
Lenz, T, Bonnist, E Y M, Pljevaljcic, G, Neely, R K, Dryden, D T F, Scheidig, A J, Jones, A C & Weinhold, E 2007, ' 2-Aminopurine flipped into the active site of the adenine-specific DNA methyltransferase M.Taql: Crystal structures and time-resolved fluorescence ', Journal of the American Chemical Society, vol. 129, no. 19, pp. 6240-6248 . https://doi.org/10.1021/ja069366n
We report the crystal structure of the DNA adenine-N6 methyltransferase, M.TaqI, complexed with DNA, showing the fluorescent adenine analog, 2-aminopurine, flipped out of the DNA helix and occupying virtually the same position in the active site as t
Autor:
Paul D. A. Pudney, Hugh Rieley, Eleanor Y. M. Bonnist, Rachel Nicholls, Kevin J. Mutch, Samuel Stanfield
Publikováno v:
Applied spectroscopy. 67(12)
This paper describes the application of Raman spectroscopy to whole hair fibers. Previously this has proved difficult because the hairs are relatively opaque, and spatial resolution diminishes with depth because of the change in refractive index. A s
Autor:
Eleanor Y. M. Bonnist, Jean-Phillipe Gorce, Cameron MacKay, Ruth U. Pendlington, Paul D. A. Pudney, P. M. Champion, L. D. Ziegler
Publikováno v:
AIP Conference Proceedings.
Publikováno v:
Journal of the Optical Society of America. A, Optics, image science, and vision. 25(5)
A new, simple, and hardware-only fluorescence-lifetime-imaging microscopy (FLIM) is proposed to implement on-chip lifetime extractions, and their signal-to-noise-ratio based on statistics theory is also deduced. The results are compared with Monte Ca
Publikováno v:
Youngblood, B, Bonnist, E, Dryden, D T F, Jones, A C & Reich, N O 2008, ' Differential stabilization of reaction intermediates: specificity checkpoints for M.EcoRI revealed by transient fluorescence and fluorescence lifetime studies ', Nucleic Acids Research, vol. 36, no. 9, pp. 2917-2925 . https://doi.org/10.1093/nar/gkn131
Nucleic Acids Research
Nucleic Acids Research
M.EcoRI, a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase, relies on a complex conformational mechanism to achieve its remarkable specificity, including DNA bending, base flipping and intercalation into the DNA. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ca5de82ef0b9fea95a4c567971807d
https://www.pure.ed.ac.uk/ws/files/8735351/Differential_stabilization_of_reaction_intermediates.pdf
https://www.pure.ed.ac.uk/ws/files/8735351/Differential_stabilization_of_reaction_intermediates.pdf