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pro vyhledávání: '"Eleanor Torode"'
Autor:
Sylvie Gomez, Karine Malagu, Thomas Presnot, Sally Ewen, Mihiro Sunose, Xiao-Ling Fan Cockcroft, Niall M. B. Martin, Alexandra Fundo, Armelle Le Gall, Keith Allan Menear, Hermann Gesine Johanna, Luisa Sebastian, Kristel Blackburn, Ian Hickson, Christine Bailey, Graeme C. M. Smith, Eleanor Torode, Kurt Gordon Pike
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5898-5901
A pharmacophore mapping approach, derived from previous experience of PIKK family enzymes, was used to identify a hit series of selective inhibitors of the mammalian target of rapamycin (mTOR). Subsequent refinement of the SAR around this hit series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5847355afd0c1842bfbfbdcbcce2b812
https://doi.org/10.1016/j.bmcl.2009.08.069
https://doi.org/10.1016/j.bmcl.2009.08.069
