Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eleanor R. Gaunt"'
Autor:
Ola Diebold, Shu Zhou, Colin Peter Sharp, Blanka Tesla, Hou Wei Chook, Paul Digard, Eleanor R. Gaunt
Publikováno v:
Viruses, Vol 16, Iss 9, p 1396 (2024)
RNA virus polymerases carry out multiple functions necessary for successful genome replication and transcription. A key tool for molecular studies of viral RNA-dependent RNA polymerases (RdRps) is a ‘minigenome’ or ‘minireplicon’ assay, in wh
Externí odkaz:
https://doaj.org/article/649d76dd16144eba9938d652aed9fa91
Autor:
Katrina M. Morris, Anamika Mishra, Ashwin A. Raut, Eleanor R. Gaunt, Dominika Borowska, Richard I. Kuo, Bo Wang, Periyasamy Vijayakumar, Santhalembi Chingtham, Rupam Dutta, Kenneth Baillie, Paul Digard, Lonneke Vervelde, David W. Burt, Jacqueline Smith
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/5370ab1a7b1f4d15b26fff508d09c4ec
Autor:
Katrina M. Morris, Anamika Mishra, Ashwin A. Raut, Eleanor R. Gaunt, Dominika Borowska, Richard I. Kuo, Bo Wang, Periyasamy Vijayakumar, Santhalembi Chingtham, Rupam Dutta, Kenneth Baillie, Paul Digard, Lonneke Vervelde, David W. Burt, Jacqueline Smith
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionHighly pathogenic avian influenza (HPAI) viruses, such as H5N1, continue to pose a serious threat to animal agriculture, wildlife and to public health. Controlling and mitigating this disease in domestic birds requires a better understand
Externí odkaz:
https://doaj.org/article/0c771ab9c6154743906b0e5a08ab25cb
Influenza A virus has long been known to encode 10 major polypeptides, produced, almost without exception, by every natural isolate of the virus. These polypeptides are expressed in readily detectable amounts during infection and are either fully ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f77cec9147bfee87231fc24e03c1fb
https://zenodo.org/record/7547697
https://zenodo.org/record/7547697
Many clinically important viruses, including influenza A, SARS-CoV-1, adenoviruses, and DNA tumour viruses such as Kaposi’s sarcoma herpesvirus use multivalent binding to sialic acid (SA) to infect cells, or to modulate immune responses through int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24cdd75eb5c8f2ffeeb4f97b92c7343
https://doi.org/10.1101/2022.10.06.511107
https://doi.org/10.1101/2022.10.06.511107
Autor:
Colin P Sharp, Beth H Thompson, Tessa J Nash, Ola Diebold, Rute M Pinto, Luke Thorley, Yao-Tang Lin, Samantha Sives, Helen Wise, Sara Clohisey Hendry, Finn Grey, Lonneke Vervelde, Peter Simmonds, Paul Digard, Eleanor R Gaunt
Publikováno v:
Sharp, C P, Thompson, B H, Nash, T J, Diebold, O, Pinto, R M, Thorley, L, Lin, Y-T, Sives, S, Wise, H, Clohisey Hendry, S, Grey, F, Vervelde, L, Simmonds, P, Digard, P & Gaunt, E R 2023, ' CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy ', PLoS Pathogens, vol. 19, no. 5, e1011357, pp. 1-34 . https://doi.org/10.1371/journal.ppat.1011357
Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f0e8cd1673b92293ecd43eb8616458
https://doi.org/10.1101/2022.04.29.490024
https://doi.org/10.1101/2022.04.29.490024
Publikováno v:
Virus Research. 321:198927
Bovine Herpesvirus Type 1 (BoHV-1) infection causes infectious bovine rhinotracheitis and genital disease in cattle, with significant economic and welfare impacts. However, the role of cellular host factors during viral replication remains poorly cha
Autor:
Eleanor R. Gaunt, Paul Digard
Publikováno v:
Wiley Interdisciplinary Reviews. RNA
Wires RNA
Gaunt, E & Digard, P 2021, ' Compositional biases in RNA viruses: causes, consequences and applications ', Wiley Interdisciplinary Reviews: RNA . https://doi.org/10.1002/wrna.1679
Wires RNA
Gaunt, E & Digard, P 2021, ' Compositional biases in RNA viruses: causes, consequences and applications ', Wiley Interdisciplinary Reviews: RNA . https://doi.org/10.1002/wrna.1679
If each of the four nucleotides were represented equally in the genomes of viruses and the hosts they infect, each base would occur at a frequency of 25%. However, this is not observed in nature. Similarly, the order of nucleotides is not random (e.g
Publikováno v:
Digard, P, Lee, H-M, Sharp, C, Grey, F & Gaunt, E 2020, ' Intra-genome variability in the dinucleotide composition of SARS-CoV-2 ', Virus Evolution . https://doi.org/10.1093/ve/veaa057
Virus Evolution
Virus Evolution
CpG dinucleotides are under-represented in the genomes of single stranded RNA viruses, and coronaviruses, including SARS-CoV-2, are no exception to this. Artificial modification of CpG frequency is a valid approach for live attenuated vaccine develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb1653b1d5108dff07dddf06e53323e
https://www.pure.ed.ac.uk/ws/files/161624474/veaa057.pdf
https://www.pure.ed.ac.uk/ws/files/161624474/veaa057.pdf
Molecular epidemiology and evolution of human respiratory syncytial virus and human metapneumovirus.
Autor:
Eleanor R Gaunt, Rogier R Jansen, Yong Poovorawan, Kate E Templeton, Geoffrey L Toms, Peter Simmonds
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17427 (2011)
Human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV) are ubiquitous respiratory pathogens of the Pneumovirinae subfamily of the Paramyxoviridae. Two major surface antigens are expressed by both viruses; the highly conserved fusio
Externí odkaz:
https://doaj.org/article/de4859d787f847d5a5cfd243e16fe9a1