Výsledky vyhledávání - "Eleanor M. Williams"

Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes

Autor: Douglas I. Grove, Li Hsu, Laura Cousens, Peggy L. Porter, Cassandra L. Neal, Hillary Massa, Janet R. Daling, Kathleen E. Malone, Barbara J. Trask, Jeri Glogovac, Christopher I. Li, Ilona N. Holcomb, Jeffrey J. Delrow, Lenora W. M. Loo, Elizabeth L. Schubert, Eleanor M. Williams

Publikováno v: Cancer Research. 64:8541-8549

In this study, we performed high-resolution array comparative genomic hybridization with an array of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted to exclude non-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0cb6785ef33f90f96bf46f96af8ef4b
https://doi.org/10.1158/0008-5472.can-04-1992

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Genomic binding by theDrosophilaMyc, Max, Mad/Mnt transcription factor network

Autor: Sarah B. Pierce, Robert N. Eisenman, Tomoyuki Sawado, Cynthia Yost, Eleanor M. Williams, Susan M. Parkhurst, Jeffrey J. Delrow, Lenora W. M. Loo, Bruce A. Edgar, Ling Li, Harmen J. Bussemaker, Shaun M. Cowley, Bas van Steensel, Amir Orian

Publikováno v: Genes & Development. 17:1101-1114

The Myc/Max/Mad transcription factor network is critically involved in cell behavior; however, there is relatively little information on its genomic binding sites. We have employed the DamID method to carry out global genomic mapping of theDrosophila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd28bba6a4aadc869e5128f25399876
https://doi.org/10.1101/gad.1066903

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Different evolutionary processes shaped the mouse and human olfactory receptor gene families

Autor: Joseph A. Ross, Cynthia Friedman, Eleanor M. Williams, Barbara J. Trask, Lori Tonnes-Priddy, Janet M. Young

Publikováno v: Human Molecular Genetics. 11:535-546

We report a comprehensive comparative analysis of human and mouse olfactory receptor (OR) genes. The OR family is the largest mammalian gene family known. We identify approximately 93% of an estimated 1500 mouse ORs, exceeding previous estimates and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dbf0eec9b0c94ba8cfed79e3d369c4
https://doi.org/10.1093/hmg/11.5.535

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Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen

Autor: Cynthia Friedman, Lee Rowen, Leroy Hood, Scott Bloom, Barbara J. Trask, Amardeep Kaur, Eleanor M. Williams, Gustavo Glusman, Cecilie Boysen, Elena V. Linardopoulou, Shizhen Qin, Mary Ellen Ahearn, Kai Wang, Jason Seto

Publikováno v: Molecular biology and evolution. 22(8)

Homo sapiens possess several trypsinogen or trypsinogen-like genes of which three (PRSS1, PRSS2, and PRSS3) produce functional trypsins in the digestive tract. PRSS1 and PRSS2 are located on chromosome 7q35, while PRSS3 is found on chromosome 9p13. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea4df7b6b1c648bc2c1d4ecd235e276
https://pubmed.ncbi.nlm.nih.gov/15901841

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Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication

Autor: Eleanor M. Williams, Barbara J. Trask, Elena V. Linardopoulou, Cynthia Friedman, Yuxin Fan, Janet M. Young

Publikováno v: Nature. 437(7055)

Human subtelomeres are polymorphic patchworks of interchromosomal segmental duplications at the ends of chromosomes. Here we provide evidence that these patchworks arose recently through repeated translocations between chromosome ends. We assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241d66c756ca69bb91960b494c2b7d6e
https://pubmed.ncbi.nlm.nih.gov/16136133

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Genomic Structure and Evolution of the Ancestral Chromosome Fusion Site in 2q13–2q14.1 and Paralogous Regions on Other Human Chromosomes

Autor: Elena V. Linardopoulou, Barbara J. Trask, Yuxin Fan, Cynthia Friedman, Eleanor M. Williams

Human chromosome 2 was formed by the head-to-head fusion of two ancestral chromosomes that remained separate in other primates. Sequences that once resided near the ends of the ancestral chromosomes are now interstitially located in 2q13–2q14.1. Po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7d0675a021700e5ff948fcdd5b89aa
https://europepmc.org/articles/PMC187548/

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