Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eleanor M. Pritchard"'
Publikováno v:
Expert Opinion on Orphan Drugs. 3:1155-1166
Introduction: Survival for patients with intraocular retinoblastoma (RB) is excellent. Over the past two decades, the focus of therapy has shifted to emphasize ocular salvage and vision preservation. The combination of chemoreduction and aggressive f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b4233b9518fde5af942c5a7c7571f9
https://doi.org/10.1517/21678707.2015.1075878
https://doi.org/10.1517/21678707.2015.1075878
Autor:
Jiakun Zhang, Elizabeth Stewart, Praveen Kumar Suryadevara, Michael A. Dyer, Cori Bradley, Lei Yang, Fangyi Zhu, Lyra Griffiths, R. Kiplin Guy, Eleanor M. Pritchard, Burgess B. Freeman
Publikováno v:
Pharmaceutical Research
Purpose Retinoblastoma is a childhood cancer of the retina. Clinical trials have shown that local delivery of broad spectrum chemotherapeutic agents is efficacious. Recent studies characterizing the genomic and epigenomic landscape of retinoblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dd8ac429a54a0d7c85849320a7c2eb
https://doi.org/10.1007/s11095-014-1399-y
https://doi.org/10.1007/s11095-014-1399-y
Autor:
Eleanor M. Pritchard, Nikki K. Lytle, Theresa A. Lusardi, Ursula S. Sandau, Joseph M. Farrell, Rebecca L. Williams-Karnesky, David L. Kaplan, Detlev Boison
Publikováno v:
Journal of Clinical Investigation. 123:3552-3563
Epigenetic modifications, including changes in DNA methylation, lead to altered gene expression and thus may underlie epileptogenesis via induction of permanent changes in neuronal excitability. Therapies that could inhibit or reverse these changes m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7c906f9bda4d2a3e020c6923b4dfb5
https://doi.org/10.1172/jci65636
https://doi.org/10.1172/jci65636
Publikováno v:
Macromolecular Bioscience. 13:311-320
Sericin removal from the core fibroin protein of silkworm silk is a critical first step in the use of silk for biomaterial-related applications, but degumming can affect silk biomaterial properties, including molecular weight, viscosity, diffusivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1409da33ef4f295c920913ce02061381
https://doi.org/10.1002/mabi.201200323
https://doi.org/10.1002/mabi.201200323
Autor:
Angelo Sassaroli, Sean M. Siebert, Hu Tao, Mark A. Brenckle, Sergio Fantini, David L. Kaplan, Jason J. Amsden, Jana M. Kainerstorfer, Jonathan M. Levitt, Bruce Panilaitis, Eleanor M. Pritchard, Fiorenzo G. Omenetto
Publikováno v:
Proceedings of the National Academy of Sciences. 109:19584-19589
Advances in personalized medicine are symbiotic with the development of novel technologies for biomedical devices. We present an approach that combines enhanced imaging of malignancies, therapeutics, and feedback about therapeutics in a single implan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7018ccd2b2b96c4edf1a4ba3e8a2cc68
https://doi.org/10.1073/pnas.1209056109
https://doi.org/10.1073/pnas.1209056109
Autor:
Bruce Panilaitis, Thomas M. Valentin, Fiorenzo G. Omenetto, Eleanor M. Pritchard, David L. Kaplan
Publikováno v:
Advanced Functional Materials. 23:854-861
Effective treatment of infections in avascular and necrotic tissues can be challenging due to limited penetration into the target tissue and systemic toxicities. Controlled release polymer implants have the potential to achieve the high local concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afc52700cd36f36eea5c22184a20045
https://doi.org/10.1002/adfm.201201636
https://doi.org/10.1002/adfm.201201636
Publikováno v:
Advanced Functional Materials. 23:58-65
Standard care for early stage breast cancer includes tumor resection and local radiotherapy to achieve long-term remission. Systemic chemotherapy provides only low locoregional control of the disease; therefore, we describe self-assembling silk hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4103be6561a8f7ef54c19eefe60aabc0
https://doi.org/10.1002/adfm.201201238
https://doi.org/10.1002/adfm.201201238
Autor:
Eleanor M. Pritchard, Bruce Panilaitis, Fiorenzo G. Omenetto, Waseem K. Raja, David L. Kaplan, Konstantinos Tsioris
Publikováno v:
Advanced Functional Materials. 22:330-335
Microneedles are emerging as a minimally invasive drug delivery alternative to hypodermic needles. Current material systems utilized in microneedles impose constraints hindering the further development of this technology. In particular, it is difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b572ef6d82a7338d1c1121c7efefb7af
https://doi.org/10.1002/adfm.201102012
https://doi.org/10.1002/adfm.201102012
Autor:
Eleanor M. Pritchard, David L. Kaplan
Publikováno v:
Expert Opinion on Drug Delivery. 8:797-811
Given the benefits of polymer drug delivery implants over traditional periodic systemic administration, the development of biomaterial systems with the necessary properties (biocompatibility, degradation, stabilization, controllability) is paramount.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488a444e6d09656bafce12bc05911b61
https://doi.org/10.1517/17425247.2011.568936
https://doi.org/10.1517/17425247.2011.568936
Publikováno v:
Biomaterials. 32:909-918
Controlling the rate of silk degradation is critical to its potential use in biomedical applications, including drug delivery and tissue engineering. The effect of protease concentration on accelerating degradation, and the use of ethylenediamine tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5cc0eeaffd86bc15b1d855485a6004
https://doi.org/10.1016/j.biomaterials.2010.09.055
https://doi.org/10.1016/j.biomaterials.2010.09.055