Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Eleanor M. Higgins"'
Autor:
Oliver R. Maguire, AnnMarie C. O'Donoghue, Matthew Rees, Steven L. Cobb, Bethany Taylor, Christopher J. Hayes, Eleanor M. Higgins, Nigel S. Simpkins
Publikováno v:
Chemical Science
The acidity of the α-proton in peptides has an essential role in numerous biochemical reactions and underpins their stereochemical integrity, which is critical to their biological function. We report a detailed kinetic and computational study of the
Autor:
Roger W. Alder, Eleanor M. Higgins, AnnMarie C. O'Donoghue, Jennifer A. Sherwood, Anita G. Lindsay, Richard S. Massey, James Armstrong
Publikováno v:
Chemical communications (Cambridge, England). 47(5)
pK(a) values of 19.8-28.2 are reported for the conjugate acids of a large series of NHCs in water. The effects of ring size, N-substituent and C(4)-C(5) saturation on pK(a) are discussed.