Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia

Autor: Eleanor L. Woodward, Minjun Yang, Larissa H. Moura-Castro, Hilda van den Bos, Rebeqa Gunnarsson, Linda Olsson-Arvidsson, Diana C. J. Spierings, Anders Castor, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Bertil Johansson, Floris Foijer, Kajsa Paulsson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

High hyperdiploid acute lymphoblastic leukaemia (HeH ALL) is driven by nonrandom chromosomal gains, which have been suggested to arise early - even before birth. Here, the authors use single-cell whole genome sequencing and in silico modelling to sho

Externí odkaz: https://doaj.org/article/64d0d9d155f840b1a5e6a3ed8a02925f

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

Autor: Rozbeh Jafari, Anders Castor, Henrik Lilljebjörn, Duncan T. Odom, Mattias Vesterlund, Linda Olsson, Minjun Yang, Kajsa Paulsson, Naveen Ravi, Ioannis Siavelis, Eleanor L. Woodward, Janne Lehtiö, Louise Harewood, Larissa H. Moura-Castro, Thoas Fioretos

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16600b044471be8bd09c1c78c5151683
https://doaj.org/article/8fb5db51725140f997f862673ee0cf51

Genomic Heterogeneity and Clonal Evolution in High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Autor: Kajsa Paulsson, Larissa H. Moura-Castro, Minjun Yang, Floris Foijer, Hilda van den Bos, Eleanor L. Woodward, Diana C.J. Spierings

Publikováno v: Blood. 138:3489-3489

High hyperdiploid (HeH) B-cell precursor acute lymphoblastic leukemia (BCP ALL) is characterized by a very specific nonrandom gain of chromosomes; a feature distinct from other types of aneuploid tumor types that usually display very heterogeneous ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfcb19ff5b5402dfff02f6eb7e80a3ce
https://doi.org/10.1182/blood-2021-145521

Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines

Autor: Kajsa Paulsson, Johan Wennerberg, Minjun Yang, Eleanor L. Woodward, Andrea Biloglav, Lars Ekblad, Naveen Ravi

Publikováno v: Endocrine-Related Cancer. :X2

Anaplastic thyroid cancer (ATC) is a highly malignant disease with a very short median survival time. Few studies have addressed the underlying somatic mutations, and the genomic landscape of ATC thus remains largely unknown. In the present study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392e40be00f6114dae86a4d14f0f223a
https://doi.org/10.1530/erc-16-0522e

Allelic Forms Of PRDM9 Associated With High Hyperdiploid Childhood Acute Lymphoblastic Leukaemia

Autor: Kajsa Paulsson, Eleanor L. Woodward, Martin L. Olsson, Bertil Johansson

Publikováno v: Blood. 122:1351-1351

Whilst a great deal is known about acquired somatic aberrations associated with the diagnosis and prognosis of acute leukaemias, relatively little is known about the effects of germline variation. A recent study reported a link between germline varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3aa0f0b5d80ed6a429f267132fcc6349
https://doi.org/10.1182/blood.v122.21.1351.1351