Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Eleanor K. Spicer"'
Autor:
Eleanor K. Spicer, Daniel J. Fernandes, Baby G. Tholanikunnel, Stephanie Dellis, Sumita Bandyopadhyay, Tapas K. Sengupta, Sivakumar Ramalingam, Daniella Ishimaru
Supplementary Data from Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df104e938ce4a574b597cca23a99698
https://doi.org/10.1158/1541-7786.22519545
https://doi.org/10.1158/1541-7786.22519545
Autor:
Daniel J. Fernandes, Nigel Courtenay-Luck, Eleanor K. Spicer, Weiwei Chen, Sridharan Soundararajan
Supplementary Figure 2 from The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2e492c0e9488edd1a4d5544ad2be5a
https://doi.org/10.1158/0008-5472.22371132
https://doi.org/10.1158/0008-5472.22371132
Autor:
Daniel J. Fernandes, Nigel Courtenay-Luck, Eleanor K. Spicer, Weiwei Chen, Sridharan Soundararajan
We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells. Furthermore, we examined the efficacy of the aptamer AS1411 in targeting nucleol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25937b31ab2603e4693a4d6fd5c4fa0b
https://doi.org/10.1158/0008-5472.c.6496677
https://doi.org/10.1158/0008-5472.c.6496677
Autor:
Daniel J. Fernandes, Nigel Courtenay-Luck, Eleanor K. Spicer, Weiwei Chen, Sridharan Soundararajan
Supplementary Figure Legends 1-2 from The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf9ecc28b450d07a8d0d97ed34b9aaf
https://doi.org/10.1158/0008-5472.22371126
https://doi.org/10.1158/0008-5472.22371126
Autor:
Daniel J. Fernandes, Nigel Courtenay-Luck, Eleanor K. Spicer, Weiwei Chen, Sridharan Soundararajan
Supplementary Figure 1 from The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e8099718eb97a7e479203741bf9fbf
https://doi.org/10.1158/0008-5472.22371135
https://doi.org/10.1158/0008-5472.22371135
Autor:
Kusumam Joseph, Karthikeyan Kandasamy, Baby G. Tholanikunnel, Eleanor K. Spicer, Kothandharaman Subramaniam
Publikováno v:
Molecular and Cellular Biochemistry. 352:125-141
Posttranscriptional controls play a major role in β(2)-adrenergic receptor (β(2)-AR) expression. We recently reported that β(2)-AR mRNA translation is suppressed by elements in its 3'-untranslated region (UTR). We also identified T-cell-restricted
Autor:
Eleanor K. Spicer, Daniella Ishimaru, Tapas K. Sengupta, Lisa Zuraw, Adrian Reuben, Sumita Bandyopadhyay, Sivakumar Ramalingam, Daniel J. Fernandes
Publikováno v:
Journal of Biological Chemistry. 285:27182-27191
The antiapoptotic Bcl-2 protein is overexpressed in a variety of cancers, particularly leukemias. In some cell types this is the result of enhanced stability of bcl-2 mRNA, which is controlled by elements in its 3'-untranslated region. Nucleolin is o
Autor:
Nigel Courtenay-Luck, Sridharan Soundararajan, Li Wang, Weiwei Chen, David R. Jones, Eleanor K. Spicer, Vijayalakshmi Sridharan, Daniel J. Fernandes
Publikováno v:
Molecular Pharmacology. 76:984-991
AS1411 is a DNA aptamer that is in phase II clinical trials for relapsed or refractory acute myeloid leukemia and for renal cell carcinoma. AS1411 binds to nucleolin, a protein that is overexpressed in the cytoplasm and on the plasma membrane of some
The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells
Autor:
Sridharan Soundararajan, Nigel S. Courtenay-Luck, Daniel J. Fernandes, Eleanor K. Spicer, Weiwei Chen
Publikováno v:
Cancer Research. 68:2358-2365
We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells. Furthermore, we examined the efficacy of the aptamer AS1411 in targeting nucleol
Publikováno v:
Molecular and cellular biochemistry. 417(1-2)
Nucleolin is a proliferation-associated protein that is overexpressed in multiple types of cancer. The mechanisms leading to overexpression of nucleolin in specific cancers are not fully understood. This study found that nucleolin is notably elevated