Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eleanor K. Pickett"'
Autor:
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotype
Externí odkaz:
https://doaj.org/article/5c607706c23f4f7d92a682e925ca0372
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
Alzheimer's & Dementia. 16
Background: Recent attention has turned to the development of preventative treatments for Alzheimer’s disease (AD) by targeting the early stages of impairment. However, current neuropsychological and functional assessments are not ideally suited to
Autor:
Pooja Jain, Jane Tulloch, Abigail G. Herrmann, Tara L. Spires-Jones, Anna J. Stevenson, Olga Netsyk, Oliver Hardt, Iris Oren, Eleanor K. Pickett
Publikováno v:
Tulloch, J, Netsyk, O, Pickett, E, Herrmann, A, Jain, P, Stevenson, A, Oren, I, Hardt, O & Spires-Jones, T 2020, ' Maintained memory and long-term potentiation in a mouse model of Alzheimer’s disease with both amyloid pathology and human tau ', European Journal of Neuroscience . https://doi.org/10.1111/ejn.14918
European Journal of Neuroscience
European Journal of Neuroscience
One of the key knowledge gaps in the field of Alzheimer's disease research is the lack of understanding of how amyloid beta and tau cooperate to cause neurodegeneration. We recently generated a mouse model (APP/PS1 + Tau) that develops amyloid plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a042a42f3702fbf4b48111c4dbfa2a
https://www.pure.ed.ac.uk/ws/files/156892620/Tulloch2020_ACCEPTED_FOR_PURE.pdf
https://www.pure.ed.ac.uk/ws/files/156892620/Tulloch2020_ACCEPTED_FOR_PURE.pdf
Autor:
Tara L. Spires-Jones, Jane Tulloch, Pooja Jain, Olga Netsyk, Anna J. Stevenson, Iris Oren, Oliver Hardt, Abigail G. Herrmann, Eleanor K. Pickett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7453ff77f8ae226fe5ab183b48c81e4a
https://doi.org/10.1111/ejn.14918/v2/response1
https://doi.org/10.1111/ejn.14918/v2/response1
Publikováno v:
Henstridge, C M, Pickett, E & Spires-Jones, T L 2016, ' Synaptic pathology: a shared mechanism in neurological disease ', Ageing Research Reviews . https://doi.org/10.1016/j.arr.2016.04.005
Synaptic proteomes have evolved a rich and complex diversity to allow the exquisite control of neuronal communication and information transfer. It is therefore not surprising that many neurological disorders are associated with alterations in synapti
Autor:
C. McKenzie, Jane Tulloch, Monique Hooley, Rosemary J. Jackson, Sadaf Sohrabi, Marie d'Orange, Elizabeth Allison, Kimberly Abt, Makis Tzioras, Anna J. Stevenson, Maria P. Fjeldstad, Sophie Dunnett, Will Calkin, Colin Smith, Giles E. Hardingham, Owen Dando, Caitlin Davies, Leo Murison, Eleanor K. Pickett, Tara L. Spires-Jones, Iris Oren, Christopher M. Henstridge, Jamie McQueen, Abigail G. Herrmann, Oliver Hardt, Jamie Rose, Pooja Jain
Publikováno v:
SSRN Electronic Journal.
SummaryOne of the key knowledge gaps blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) and tau cooperate in causing disease phenotypes. Within a mouse tau deficient ba
Autor:
Eleanor K, Pickett, Christopher M, Henstridge, Elizabeth, Allison, Rose, Pitstick, Amy, Pooler, Susanne, Wegmann, George, Carlson, Bradley T, Hyman, Tara L, Spires-Jones
Publikováno v:
Synapse (New York, N.y.)
Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process. Despite the knowledge that tau spreads through
Autor:
Bradley T. Hyman, Susanne Wegmann, George A. Carlson, Rosemary J. Jackson, Christopher M. Henstridge, Eleanor K. Pickett, Abigail G. Herrmann, Tara L. Spires-Jones
Publikováno v:
Alzheimer's & Dementia. 12
Autor:
Dominic M. Walsh, Bradley T. Hyman, Martí Colom-Cadena, Tara L. Spires-Jones, Kevin R Kay, Christopher M. Henstridge, Susanne Wegmann, Eleanor K. Pickett, Robert M. Koffie, Abigail G. Herrmann, Melissa Vaught, Alberto Lleó, Roy J. Soberman
Publikováno v:
Pickett, E, Koffie, R, Wegmann, S, Henstridge, C, Herrmann, A, Colom-Cadena, M, Lleo, A, Kay, K, Vaught, M, Soberman, R, Walsh, D, Hyman, B & Spires-Jones, T 2016, ' Non-fibrillar oligomeric amyloid-β within synapses ', Journal of Alzheimer's Disease . https://doi.org/10.3233/JAD-160007
Alzheimer's disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of amyloid-β (Aβ) peptide in senile plaques and intracellular accumulation of tau in neurofibrilla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65022e0be284c4ca80b35ba60293dc06
https://hdl.handle.net/20.500.11820/75ea610e-7368-40ce-922c-acd301aa3aba
https://hdl.handle.net/20.500.11820/75ea610e-7368-40ce-922c-acd301aa3aba