Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eleanor J Tyler"'
Autor:
Roberto A. Avelar, Javier Gómez Ortega, Robi Tacutu, Eleanor J. Tyler, Dominic Bennett, Paolo Binetti, Arie Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, Vadim E. Fraifeld, Cleo L. Bishop, João Pedro de Magalhães
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensiv
Externí odkaz:
https://doaj.org/article/7b84219b475d4993ae23863cf7f41947
Autor:
Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110227- (2022)
Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. Here, we show that the Rho effector
Externí odkaz:
https://doaj.org/article/4cdf1de664b34a7d9beec6238fad7a6b
Autor:
Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M.T. Pearce
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102676- (2021)
Summary: Guided by a multi-level “deconstruction” of omental metastases, we developed a tetra (four cell)-culture model of primary human mesothelial cells, fibroblasts, adipocytes, and high-grade serous ovarian cancer (HGSOC) cell lines. This mul
Externí odkaz:
https://doaj.org/article/99a346004e8b4e63bd0a6643a5d15ba8
Autor:
Atiya M. Sarmin, Nadia El Moussaid, Ratima Suntornnond, Eleanor J. Tyler, Yang-Hee Kim, Stefania Di Cio, William V. Megone, Oliver Pearce, Julien E. Gautrot, Jonathan Dawson, John T. Connelly
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 837 (2022)
The extracellular matrix (ECM) is a complex mixture of structural proteins, proteoglycans, and signaling molecules that are essential for tissue integrity and homeostasis. While a number of recent studies have explored the use of decellularized ECM (
Externí odkaz:
https://doaj.org/article/8cb50e48df024102aa910c73c6481901
Autor:
Ryan Wallis, Natasa Josipovic, Hannah Mizen, Arturo Robles‐Tenorio, Eleanor J. Tyler, Argyris Papantonis, Cleo L. Bishop
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP). Through the SASP, senescent cells are hypothesis
Externí odkaz:
https://doaj.org/article/98e9cf05b0164232b005331798fd251b
Autor:
Edward P Carter, Kubra K Yoneten, Nuria Gavara, Eleanor J Tyler, Valentine Gauthier, Elizabeth R Murray, Angus J Cameron, Oliver Pearce, Richard P Grose
Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in differentiation of stellate cells into myofibroblasts that drive. To assess co-operative mechanisms in a 3D context, we generated chimeric spheroids using human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89305c8534494a6e16e544281650497
https://doi.org/10.1101/2022.09.20.508645
https://doi.org/10.1101/2022.09.20.508645
Autor:
Ryan Wallis, Deborah Milligan, Bethany Hughes, Hannah Mizen, José Alberto López-Domínguez, Ugochim Eduputa, Eleanor J. Tyler, Manuel Serrano, Cleo L. Bishop
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Senescence occurs in response to a number of damaging stimuli to limit oncogenic transformation and cancer development. As no single, universal senescence marker has been discovered, the confident classification of senescence induction requires the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d567939ea9bb3fe0fad34bfc967f0b
http://hdl.handle.net/2445/185905
http://hdl.handle.net/2445/185905
Autor:
Eleanor J. Tyler, Ryan Wallis, Robert Lowe, Martha R. Stampfer, Cleo L. Bishop, Bethany K. Hughes, Ana Gutierrez del Arroyo, Michael P. Philpott, James C. Garbe, Jim Koh
Publikováno v:
Aging Cell
Aging cell, vol 20, iss 3
Aging cell, vol 20, iss 3
Senescence, a state of stable growth arrest, plays an important role in ageing and age‐related diseases in vivo. Although the INK4/ARF locus is known to be essential for senescence programmes, the key regulators driving p16 and ARF transcription re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734ae8cda37b2be024a179867c806cbb
http://europepmc.org/articles/PMC7963333
http://europepmc.org/articles/PMC7963333
Autor:
Cleo L. Bishop, Bethany K. Hughes, James C. Garbe, Martha R. Stampfer, Robert Lowe, Ana Gutierrez del Arroyo, Ryan Wallis, Michael P. Philpott, Eleanor J. Tyler, James Koh
SummarySenescence, a state of stable growth arrest, plays an important role in ageing and age-related diseases in vivo. Although the INK4/ARF locus is known to be essential for senescence programs, the key regulators driving p16 and ARF transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60756edfdc90e565879a94f825475bae
https://doi.org/10.1101/2020.09.30.321190
https://doi.org/10.1101/2020.09.30.321190
Autor:
Cleo L. Bishop, Emily Johnson, João Pedro de Magalhães, Daniel Thornton, Vadim E. Fraifeld, Robi Tacutu, Arie Budovsky, Samuel Shields, Dominic Bennett, Daniela Tejada-Martinez, Eleanor J. Tyler, Alex Murray, Paolo Binetti, Kasit Chatsirisupachai, Roberto A. Avelar, Javier Gómez Ortega
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Genome Biology
Genome Biology
Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54255d0479e93342aa6c9b8ab4a16d96
https://doi.org/10.1186/s13059-020-01990-9
https://doi.org/10.1186/s13059-020-01990-9