Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eleanor I Ager"'
Publikováno v:
Journal of Gastroenterology and Hepatology. 31:1773-1782
Background and Aim Epithelial to mesenchymal transition (EMT) is implicated in tumor progression. We aimed to determine if the renin angiotensin system has a role in colorectal cancer (CRC) cell EMT. Methods Human CRC cell lines DLD-1 and LIM2405 wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bbf40850ff944da016e18eb30ceec37
https://doi.org/10.1111/jgh.13307
https://doi.org/10.1111/jgh.13307
Autor:
Alexander J. Stevenson, Brian Gabrielli, Martina Proctor, Andrew Heaton, David R. Brown, Dubravka Skalamera, Eleanor I Ager
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Successive rounds of chemical modification in three generations of benzopyran molecules have shown to select for different mechanisms of actions and progressive increases in anti-cancer activity. In this study, we investigated the mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fd77fc4b4914fd2749b7cdf1574b9f
https://doi.org/10.1038/s41598-018-22882-w
https://doi.org/10.1038/s41598-018-22882-w
Autor:
Brian P. Walcott, Nathaniel D. Kirkpatrick, Cristina T. Kesler, Dan G. Duda, Benjamin J. Vakoc, Rakesh K. Jain, Matija Snuderl, Dai Fukumura, Timothy P. Padera, Nisha Gupta, Rekha Samuel, John Yazbek, Eleanor I Ager, Shuhan Wang, Randall T. Peterson, Takahiro Heishi, Shom Goel, John D. Martin, Yuhui Huang
Publikováno v:
JNCI: Journal of the National Cancer Institute. 105:1188-1201
Unlike blood vessels in healthy tissue, the solid tumor microvasculature is dysfunctional and immature. Tumor vessels harbor structural and functional instability, which facilitates several distinct stages of tumor progression, including early sprout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619a74b6a9ff5e54a829101fe4d343fd
https://doi.org/10.1093/jnci/djt164
https://doi.org/10.1093/jnci/djt164
Autor:
Eleanor I Ager, Christopher Christophi, Shir Lin Koh, Vijayaragavan Muralidharan, Caterina Malcontenti-Wilson
Publikováno v:
Journal of Surgical Research. 179:66-71
Background Partial hepatectomy is the preferred option for selected patients with colorectal cancer liver metastases (CRCLM). Sufficient liver regeneration (LR) is essential for a successful outcome in these patients. The blockade of the renin–angi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e7a60f1719df0c48cea7635618673b
https://doi.org/10.1016/j.jss.2012.09.007
https://doi.org/10.1016/j.jss.2012.09.007
Autor:
Dai Fukumura, David P. Kodack, Youngchul Song, Yinyin Huang, Shom Goel, Bakhos A. Tannous, L Hiddingh, Rakesh K. Jain, Matija Snuderl, Walid S. Kamoun, Euiheon Chung, Christian T. Farrar, Hiroshi Yamashita, Jeffrey A. Engelman, Eleanor I Ager, Joao Incio, A Lussiez, A Peters
Publikováno v:
Cancer Research. 72:P3-12
Brain metastases remain a serious obstacle in the treatment of patients with human epidermal growth factor receptor-2 (HER2)-amplified breast cancer. Unlike HER2-amplified breast tumors growing in extra-cranial locations, brain metastases do not resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14349316ba14105ce85c65261843371b
https://doi.org/10.1158/0008-5472.sabcs12-p3-12-03
https://doi.org/10.1158/0008-5472.sabcs12-p3-12-03
Publikováno v:
Liver International. 30:1414-1426
Liver resection is the most effective treatment for primary liver tumours and metastasis to the liver, and remains the only potentially long-term curative therapy for patients with colorectal cancer (CRC) liver metastases. Nevertheless, there is a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee827b4e94565560a8c0906dc70cfa5
https://doi.org/10.1111/j.1478-3231.2010.02306.x
https://doi.org/10.1111/j.1478-3231.2010.02306.x
Publikováno v:
REPRODUCTION. 136:523-531
Genomic imprinting is a widespread epigenetic phenomenon in eutherian mammals, which regulates many aspects of growth and development. Parental conflict over the degree of maternal nutrient transfer is the favoured hypothesis for the evolution of imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc82f0207cc0dd40f52ea95c61ede58
https://doi.org/10.1530/rep-08-0264
https://doi.org/10.1530/rep-08-0264
Publikováno v:
Carcinogenesis. 29:1675-1684
The renin-angiotensin system (RAS) is usually associated with its systemic action on cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level, the RAS influences tumour growth. The potential of the RAS as a target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72799e369ee2b5d979d69aa9326ec9a7
https://doi.org/10.1093/carcin/bgn171
https://doi.org/10.1093/carcin/bgn171
Autor:
Geoff Shaw, Eleanor I Ager, Fumitoshi Ishino, Andrew J Pask, Marilyn B. Renfree, Shunsuke Suzuki
Publikováno v:
Developmental Biology. 309:317-328
Therian mammals (marsupials and eutherians) rely on a placenta for embryo survival. All mammals have a yolk sac, but while both chorio-allantoic and chorio-vitelline (yolk sac) placentation can occur, most marsupials only develop a yolk sac placenta.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31acf228dd77db729622fd7074540b77
https://doi.org/10.1016/j.ydbio.2007.07.025
https://doi.org/10.1016/j.ydbio.2007.07.025
Publikováno v:
Journal of gastroenterology and hepatology. 31(10)
Epithelial to mesenchymal transition (EMT) is implicated in tumor progression. We aimed to determine if the renin angiotensin system has a role in colorectal cancer (CRC) cell EMT.Human CRC cell lines DLD-1 and LIM2405 were used in wound scratch migr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::820cb2c9d17dd4dd7489ec17a32187f4
https://pubmed.ncbi.nlm.nih.gov/26849969
https://pubmed.ncbi.nlm.nih.gov/26849969